Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
24/01/2019	C-reactive protein as a biomarker of response to inhaled corticosteroids in COPD
24/01/2019	Characterizing type 2 diabetes mellitus (T2DM) patients trajectories and health outcomes - understanding and predicting co-morbidities, risk factors and complications
25/01/2019	Inflammatory Skin Diseases and the Risk of Chronic Kidney Disease - Cross-sectional and Cohort Studies
29/01/2019	Improving treatment of people with dementia and additional health conditions
29/01/2019	Fractured wrist; predictors of poor long-term clinical and socioeconomic outcomes (The FILTER Study)
29/01/2019	Incidence of major adverse cardiovascular and cerebrovascular events (MACE) in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis: a retrospective analysis of a United Kingdom database
01/02/2019	Characterising end of life health care expenditure
04/02/2019	Estimating the prevalence of transthyretin amyloid cardiomyopathy in the UK
05/02/2019	The association of cancer and autism spectrum condition in a UK population
05/02/2019	Type 2 Diabetes in women after a diagnosis of gestational diabetes: understanding uptake to screening and progression rates- a retrospective cohort study in the CPRD database
07/02/2019	Validation of Asthma-COPD Overlap Syndrome in the Clinical Practice Research Datalink (CPRD)
08/02/2019	Treatment pathways to severe asthma and health care resource utilisation in the UK
08/02/2019	Trends in incidence of first diabetic foot ulcer and mortality in patients with type I and type II diabetes mellitus
08/02/2019	Risks of antidepressants on cardiovascular mortality and morbidity, suicidality, falls and fractures in people with obesity and depression in primary care
08/02/2019	Investigating the extent to which exposure to varicella boosts Varicella zoster virus-immunity: a self-controlled case-series, 1997-2018
11/02/2019	Evaluation of clinical progression of chronic kidney disease and its predictors using statistical and machine learning techniques: a retrospective cohort study from United Kingdom
11/02/2019	The weight loss effects of glucagon-like peptide-1 receptor agonists and the risk of breast cancer in women with type 2 diabetes
11/02/2019	Utilization, Effectiveness, and Safety of SGLT2 Inhibitors Among Patients with Type 2 Diabetes Mellitus
12/02/2019	What are the optimal blood pressure targets for patients in atrial fibrillation treated with non-vitamin K antagonist oral anticoagulants?
12/02/2019	Use of Sodium-glucose co-transporter-2 inhibitors, changes in body mass index and risk of major osteoporotic fracture