Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
11/03/2019	A matched population-based case control study to determine which clinical features are associated with the inherited cardiac conditions, bicuspid aortic valve and long QT syndrome in primary care
12/03/2019	The impact of the National Data Opt-out programme on representativeness of the Clinical Practice Research Datalink (CPRD) database
12/03/2019	Determining the optimal timing of triple therapy initiation in patients with chronic obstructive pulmonary disease (COPD) in the United Kingdom (UK): A retrospective, longitudinal cohort study
12/03/2019	Database - Prescription Event Monitoring (D-PEM) study to identify, quantify and characterise identified adverse events associated with the use of a widely prescribed medication in primary care in the UK
13/03/2019	Delayed treatment intensification and risk of micro- and macrovascular complications in insulin-treated patients with type 2 diabetes; a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
13/03/2019	Bereavement amongst those with chronic kidney disease - does it affect outcomes?
13/03/2019	Ethnic differences in the prescribing of anti-diabetic, antihypertensive and lipid-lowering medication for people with and without type 2 diabetes
13/03/2019	Risk of Nephrotic Syndrome in Children with Atopic Eczema – a matched case-control study
13/03/2019	Epidemiology of Endometriosis in the Adolescent Population
18/03/2019	Data analysis of the current treatments for major depressive disorder and treatment resistant depression in the United Kingdom
18/03/2019	Developing and validating a novel clinical severity index for cardiovascular disease in primary care
18/03/2019	Defining obesity cut-off points for the risk of type 2 diabetes, cardiovascular disease, and cancer among minority ethnic groups: a prospective cohort study using population-based linked electronic health records
19/03/2019	The evaluation of risk factors and long-term outcomes in patients with community- or hospital- acquired sepsis: a retrospective cohort study using linked primary and secondary care data
19/03/2019	Validation of CPRD database transformed to Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM)
19/03/2019	Juvenile Idiopathic Arthritis (JIA): occurrence, comorbidity and healthcare utilisation
19/03/2019	Validation of a Risk Estimation Algorithm for Predicting the Early Risk of Chronic Kidney Disease in Newly Diagnosed Diabetics Based on General Practitioners’ Records in the United Kingdom
22/03/2019	Maternal infections and antibiotic treatment associated with long-term child conditions
22/03/2019	A Feasibility Study to Examine Treatment Patterns for Secondary Stroke Prevention among Patients with Ischemic Stroke or Transient Ischemic Attack
22/03/2019	Sodium channel-inhibiting drugs and cancer survival: a cohort study
26/03/2019	All Cause and Cardiovascular Mortality in type 2 diabetes patients using Detemir or Glargine