Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
29/03/2019	Risk of non-melanoma skin cancer among hypertensive adults in the United Kingdom treated with angiotensin converting enzyme inhibitors: a population based, active comparator, new user, retrospective cohort study
29/03/2019	The risk of muscular events in new users of individual hydrophilic versus lipophilic statins at equivalent doses: An observational cohort study
01/04/2019	Cardiovascular risk prediction in daily practice: can machine-learning based risk prediction models improve the accuracy of risk prediction for individual patients?
02/04/2019	An investigation into the association of asthma and fractures
02/04/2019	Hydroxychloroquine and screening for risk of ocular toxicity – how big is the problem? Epidemiology of hydroxychloroquine prescriptions in the UK Clinical Practice Research Datalink
02/04/2019	Influence of allopurinol use on hepatotoxicity risk with thiopurine use among adults and paediatrics: a retrospective population-based cohort study
04/04/2019	Differences in risk of long-term cardiovascular and renal outcomes between men and women after a reduction in kidney function following initiation of a renin-angiotensin system inhibitor
04/04/2019	To evaluate the management of varicose veins in clinical practice in the UK
04/04/2019	Effectiveness on blood pressure of a switch from a monotherapy amlodipine 5 mg toward a combination amlodipine 5 mg/ bisoprolol 5 mg versus a switch toward a monotherapy amlodipine 10 mg. A cohort study using the United Kingdom CPRD
04/04/2019	Trajectory of Weight Changes and Persistency/Adherence among Type 2 Diabetes Patients initiating GLP-1 RAs
04/04/2019	Screening for alcohol-use disorders among primary care patients with depression and consequent risk of hospitalisation
15/04/2019	Maternal post-natal GP checks: exploring the equity of care provision in England
18/04/2019	Safety of five years of pertussis vaccination in pregnancy in England: a cohort study
18/04/2019	Understanding the socioeconomic and geographical determinants of dementia care pathways
18/04/2019	Describing the characteristics of patients who die of COPD with no evidence of prior diagnosis
23/04/2019	Defining diseases clusters in adults with multimorbidity
26/04/2019	Evaluation of referral system and outcome among patients with breast and colorectal conditions
26/04/2019	Prediction of imminent fracture risk in new users of oral bisphosphonates or recently fractured subjects: a multinational European real-world cohort study
29/04/2019	International migrant healthcare access in England: a population-based linked cohort study of healthcare resource utilisation and mortality amongst international migrants registered with primary care services
01/05/2019	Incidence and clinical management of common mental illnesses, and antecedent factors associated with self-harm, among children and adolescents in a UK primary care cohort