Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
18/06/2019	Pelvic inflammatory disease, associated infections, and risk for ovarian cancer in the United Kingdom Clinical Practice Research Datalink
18/06/2019	The cumulative incidence of seizures during 21 days after new use of oral antibiotics in patients with epilepsy - a cohort study
19/06/2019	Treatment cut-offs for blood pressure lowering and lipid lowering treatment: a cohort study in UK primary care
20/06/2019	Real world costs of blindness for patients with inherited retinal dystrophies (IRDs): a non-interventional study using primary and secondary healthcare databases in the United Kingdom
25/06/2019	The effect of common infections on the risk of dementia in individuals with and without diabetes: a cohort study using UK primary and secondary care data
25/06/2019	Repurposing Drugs for the Prevention and Treatment of Dementia
28/06/2019	Trends in Acid Suppressant Drug Prescriptions in Primary Care in the United Kingdom
03/07/2019	Prescribing trends in pediatric outpatients
04/07/2019	Changes in Healthcare Resource Use (HRU) and Related Costs in Chronic Obstructive Pulmonary Disease (COPD) Patients over 9 years: A France/UK comparative study
04/07/2019	Variation in healthcare utilisation across primary and secondary care for patients with type 1 and type 2 diabetes
08/07/2019	Data analysis of patients with major depressive disorder at imminent risk for suicide in the United Kingdom
08/07/2019	Application of a clinically-driven algorithm for diagnosis of alcohol related liver disease to primary and secondary care cohorts: understanding patient journeys, engagement with healthcare services and associated outcomes
08/07/2019	Prenatal exposure to antipsychotics: the risk of adverse central nervous system outcomes in children
08/07/2019	Use, risk-benefits, and costs of preventive therapies in older people with complex health needs: an analysis of NHS routinely collected data
08/07/2019	Natriuretic peptide testing in diagnosing heart failure in primary care (DIAGNOSE-NP)
10/07/2019	A retrospective observational cohort study to identify the real-world use of oral glycopyrronium bromide in children
10/07/2019	Association of serum bilirubin level with renal outcomes in patients with type 2 diabetes and patients with essential hypertension
11/07/2019	Investigating capacity for NICE guidance on recognition and referral for suspected cancer
15/07/2019	Investigating overlapping pregnancy episodes in the Clinical Practice Research Datalink / London School of Hygiene and Tropical Medicine Pregnancy Register, with the aim of identifying and categorising validity issues.
18/07/2019	Impact of hospitalisation on Potentially Inappropriate Prescribing in older patients: a retrospective cohort study