Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
18/07/2019	Impact of hospitalisation on Potentially Inappropriate Prescribing in older patients: a retrospective cohort study
18/07/2019	Prevalence of established cardiovascular disease in patients with type 2 diabetes mellitus in the UK
23/07/2019	External validation of multivariable dementia risk prediction models in UK adults using routinely-available predictors
23/07/2019	Real world data on utilisation and safety of Movicol paediatric plain among children <2 years
24/07/2019	Dipeptidyl Peptidase-4 Inhibitors and Risk of Inflammatory Bowel Disease: Impact of Study Design Differences on Comparative Safety Results
24/07/2019	Uncontrolled blood pressure and therapeutic inertia in treated hypertensive patients: a retrospective descriptive cohort study using CPRD
24/07/2019	Comparative effectiveness of gliclazide MR and sitagliptin as second line treatment after metformin monotherapy in uncontrolled type 2 diabetes patients using the UK Clinical Practice Research Datalink (CPRD) database
26/07/2019	Trends in Prescription of Antihypertensive Medications in UK Primary Care Practices, 1988-2018
26/07/2019	Effectiveness of Pneumococcal Polysaccharide Vaccine booster dosing in preventing pneumococcal disease in adults in the United Kingdom: a database cohort study
26/07/2019	Suspected cancer symptoms and blood test results in primary care before a diagnosis of lung cancer: a case-control study
26/07/2019	5-Alpha Reductase Inhibitors and the Risk of Anaemia
26/07/2019	The balance between face-to-face and phone consultations in primary care and its effect on hospital demand: A longitudinal observational study
31/07/2019	Chronic inflammatory conditions and cardiovascular risk
31/07/2019	A non-interventional retrospective study in England and Scotland estimating the economic burden of moderate-to-severe chronic pain due to osteoarthritis (OA) or chronic low back pain (CLBP)
31/07/2019	Use of the STarT Back Screening Tool for Low Back Pain in Primary Care
05/08/2019	Occurrence and consequences of Langerhans cell histiocytosis, Malignant Histiocytosis, Erdheim-Chester Disease and Haemophagocytic Lymphohistiocytosis: a population based cohort study
05/08/2019	Association of Polycystic Ovary Syndrome with patient and offspring cardiometabolic outcomes: a retrospective, observational study
07/08/2019	Immortal Time Bias in Comparative Drug Safety Studies in Pregnancy
07/08/2019	The long-term impact of vaginal surgical mesh devices in UK primary care: a cohort study in the CPRD
08/08/2019	Characteristics and Treatment Patterns of Patients with Chronic Obstructive Pulmonary Disease (COPD), Initiating Tiotropium+Olodaterol or Other Maintenance Therapies in the UK: A Database Study