Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
15/04/2021	Propensity to order diagnostic blood tests in general practices
15/04/2021	Completeness and representativeness of ethnicity data in the UK Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES)
22/04/2021	Prediction of which patients with venous thromboembolism may benefit from an extended anticoagulation 3 months post diagnosis
23/04/2021	Risk of fractures in cancer survivors in the United Kingdom: a population-based matched cohort study using linked electronic health records databases
23/04/2021	A comparison of clinical outcomes, health care resource utilisation and costs for patients with chronic lower limb ulcers including diabetic and venous ulcers when prescribed Prontosan (including solution and gel) and saline solution in England
27/04/2021	Long COVID in non-hospitalised individuals: symptoms, risk factors and syndromes
27/04/2021	The safety of proton pump inhibitors in children with gastroesophageal reflux disease
28/04/2021	Epidemiology and burden of Illness of familial hypercholesterolaemia and hypercholesterolaemia in combination with atherosclerotic cardiovascular disease or atherosclerotic cardiovascular disease risk equivalence.
28/04/2021	Glycaemic control across ethnicity of insulin-naive type 2 diabetes patients residing in England when initiating Biphasic insulin aspart 30-70 (BIAsp 30)
29/04/2021	Multimorbidity and lipid response to statins: a cohort study
30/04/2021	Completeness and representativeness of small area socioeconomic data linked with the UK Clinical Practice Research Datalink (CPRD)
04/05/2021	The Prescribing of Analgesia and Predictors of Long-Term Analgesia Prescriptions in Patients with Inflammatory Arthritis: An Observational Study using the Clinical Practice Research Datalink.
05/05/2021	Evaluating ethnic differences in blood markers of cancer in primary care
06/05/2021	Impact of underlying diseases, diagnostic processes and treatment on heart failure disease trajectory using international data
06/05/2021	The risk of acute infection in patients with newly diagnosed depression: a cohort study
07/05/2021	Incidence and prevalence of mental illness in pregnancy and the first five years after giving birth: a retrospective cohort study using electronic primary care data
07/05/2021	Use and effectiveness of non-pharmaceutical interventions for mild to moderate depression
07/05/2021	An assessment of clinical staff workload and predictors of clinical staff workload, in UK primary care settings
11/05/2021	Association between haemoglobin levels and clinical outcomes and healthcare resource use in patients with sickle cell disease in England
11/05/2021	Patient portal registration and healthcare utilisation outcomes of patients in the NHS General Practice.