Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
02/03/2022	Systemic lupus erythematosus related organ damage and mortality
02/03/2022	Developing evidence based optimal testing strategies to monitor long term conditions in primary care
02/03/2022	Development of a personalised exacerbation prediction risk model for adults with asthma in England
03/03/2022	Safety of the Novavax COVID-19 vaccine in England: a post-authorisation safety study using data from the Clinical Practice Research Datalink (CPRD)
08/03/2022	Variations in the management of Inflammatory Bowel Disease over time: How has Covid-19 effected inflammatory bowel disease patients?
08/03/2022	The risk of pneumonia in COPD patients and COPD patients with concomitant bronchiectasis, using inhaled steroids: a UK case-control study
09/03/2022	The development and internal validation of population clusters for multiple long-term conditions using artificial intelligence approaches
09/03/2022	Anticholinergic bladder drugs and associations with dementia risk
09/03/2022	The impact of chronic kidney disease on care and outcomes of myocardial infarction in England: A cohort study.
09/03/2022	Utilization of Low-Dose Aspirin during Pregnancy and Impact of National Institute for Health and Care Excellence Guidelines on Prescription Trends
09/03/2022	Has the incidence of giant cell arteritis in England and Northern Ireland been influenced by the covid-19 pandemic? A case cohort study using CPRD Aurum data
09/03/2022	Cohort study investigating the natural history of gout in UK general practice
14/03/2022	Investigating disruptions in primary care as a result of the COVID-19 pandemic and the introduction of national lockdowns
14/03/2022	Psychiatric diagnoses and self-harm episodes among children and young people in UK primary care records before and during the COVID-19 pandemic: a population-based cohort study
14/03/2022	Combining pharmacokinetics and real-world data to improve understanding of the dose-exposure-response relationship of hormonal contraceptives
16/03/2022	Medication use in pregnancy and pregnancy outcomes in women with chronic inflammatory disease
18/03/2022	Incidence of diabetes foot ulcer disease and its association with morbidity and mortality in persons with diabetes: United Kingdom Clinical Practice Research Datalink Cohort Study.
18/03/2022	The impact of COVID-19 pandemic on health care service provision for patients with newly diagnosed cancer
18/03/2022	Characterizing long COVID patients across pre-existing physical and mental health conditions: Risk profiling using Electronic Health Records in the United Kingdom
21/03/2022	TO CHARACTERISE THE HEALTH ECONOMIC IMPACT OF SURGICAL SITE INFECTIONS IN THE UK