Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
17/04/2023	Feasibility Database study to quantify the number of Lennox-Gastaut syndrome (LGS) and LGS-like patients in the UK
17/04/2023	Safety of the Novavax COVID-19 vaccine in England using a self-controlled case series design: a post-authorisation safety study using data from Clinical Practice Research Datalink (CPRD) Aurum and linked databases
17/04/2023	Association between PCOS and Microvascular complications among women with Type 2 Diabetes: a retrospective cohort study
14/04/2023	Associations between cardiovascular, bleeding and mortality outcomes and the co-prescriptions of oral anticoagulants and other medications
12/04/2023	A retrospective cohort study of non-alcoholic steatohepatitis clinical outcomes and economic burden
12/04/2023	Feasibility study to see if two new NICE (National Institute for Health and Care Excellence) indicators on chronic kidney disease (CKD) can be measured successfully at general practice-level
11/04/2023	Artificial Intelligence and Frailty: Discovering Frailty Subtypes with Different Prognostic Profiles
11/04/2023	Exploring the effect of Chronic Obstructive Pulmonary Disease (COPD) on subsequent cardiovascular (CV) events in people with prior major CV event or are at elevated CV risk
06/04/2023	CoMPuTE: Complex Multiple Long Term Conditions - Phenotypes, Trends, and Endpoints
05/04/2023	Background rates of serious adverse events to contextualise safety assessments in clinical trials and non-interventional studies in adolescent and adult patients with severe asthma: A Data Analysis and Real World Interrogation Network (DARWIN EU) study
05/04/2023	The risk of acute infection in new users of antihypertensive drugs: a cohort study
05/04/2023	Dementia and serious health outcomes: a cohort and case control study investigating psychological distress as a risk factor
05/04/2023	Characterising treatment pathways in menopausal women: a retrospective cohort study using the Clinical Practice Research Datalink
04/04/2023	Trends in general practice skill mix: observational analysis using routine health data
04/04/2023	Paediatric Otorrhoea: Understanding the burden of disease
31/03/2023	Characterisation of acute and long-term COVID-19 symptoms and complications in primary care electronic health records from the UK
28/03/2023	Evaluation of the Representativeness of CPRD Data for Suitability to Conduct Clinical Epidemiological Studies in Patients with Lung Cancer in England : A Feasibility Study
28/03/2023	A longitudinal analysis investigating cardiovascular outcomes in people with type 2 diabetes by treatment class in England.
28/03/2023	Preventing steroid harms in people with polymyalgia rheumatica in UK primary care
28/03/2023	Prescribing of allopurinol among different ethnic groups: feasibility for a genetic study.