Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
09/02/2023	Feasibility Database study to assess the clinical and economic benefits of weight loss in people with Type 2 Diabetes (PwT2D) in CPRD-HES
09/02/2023	To assess the comparative effectiveness and real-world utilization of novel oral anticoagulants in patients with nonvalvular atrial fibrillation in the United Kingdom
09/02/2023	Development and validation of a Polypharmacy Assessment Score for potentially inappropriate polypharmacy
07/02/2023	In people living with obesity who are newly diagnosed with chronic kidney disease, does weight loss delay disease progression? A population-based cohort study using the UK clinical practice research datalink
03/02/2023	Characterisation of treatment pathways and prescription cascades of people with parkinsonism
02/02/2023	cohort studies Predicting pharmacological treatment Response In Severe Mental illness (PrISM)
02/02/2023	Assessment of LungFlag model - a lung cancer early detection algorithm
31/01/2023	Socio-demographic differences and trends in the incidence, prevalence, treatment, and outcomes of patients with aortic stenosis, a national database study
31/01/2023	The development and validation of a dementia risk prediction models in ethnically diverse populations and in the context of disease related comorbidity
30/01/2023	The ethnic variation in incidence and prevalence trends of Polycystic Ovary Syndrome (PCOS) and metabolic outcomes among women with PCOS
30/01/2023	Investigating health inequalities in people with alcohol use disorders and type 2 diabetes
30/01/2023	Cost-utility analysis: what is the most cost-effective target for cholesterol for secondary prevention of cardiovascular disease? Evidence to update NICE guideline CG181 - Cardiovascular disease: risk assessment and reduction, including lipid modification
27/01/2023	Predictors and impact of an emergency diagnosis of leukaemia: a retrospective analysis in the Clinical Practice Research Datalink
25/01/2023	Quality of the non-alcoholic steatohepatitis diagnosis recorded in the CPRD Aurum Database: a descriptive study
24/01/2023	Creating clinical evidence of treatment effects in routine populations excluded from trials
24/01/2023	The association of SGLT2-Is versus DPP4-I as add-on to metformin and risk of any fracture and major osteoporotic fractures in patients with Type 2 Diabetes Mellitus
23/01/2023	A feasibility study on maternal and child outcomes from pregnancies after bariatric surgery:
19/01/2023	Self-controlled designs with active comparators for signal detection using routinely collected clinical data: an example using antibiotics
19/01/2023	The effect of incretin-based therapy on diabetic foot ulcers and the risk of amputation in type 2 diabetes
19/01/2023	Trends in health seeking behaviour and treatment decisions, and risk factors for recurrent preschool wheeze in children from different ethnic and socioeconomic backgrounds