Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/01/2022	Identifying coincident drugs that alter headache progression and remission.
05/01/2022	Endometrial cancers: A propensity score matched study assessing different routes of surgery, and a prospective cohort study to investigate the disease epidemiology and estimate future incidence
05/01/2022	Impact of the coronavirus disease (COVID-19) pandemic on incidence of tics in children and young people: a population-based cohort study
23/12/2021	Comparative effectiveness of Umeclidinium+Vilanterol versus Tiotropium Bromide+Olodaterol among patients with Chronic Obstructive Pulmonary Disease in a real-world primary care setting in the UK
23/12/2021	Do features occurring prior to MS diagnosis vary according to background: a nested case control study
23/12/2021	RECORD-HF: A REtrospective COhort study of heart failure-Related outcomes in patients who are prescribed a loop Diuretic without a diagnosis of Heart Failure
23/12/2021	A post-authorisation (post-marketing) observational study using existing secondary health data sources to evaluate the association between exposure to the AstraZeneca COVID-19 vaccine (AZD1222) and safety concerns
23/12/2021	Patterns and clinical outcomes of cardiovascular medication use after a cancer diagnosis in patients with heart failure
22/12/2021	Longitudinal trajectories of work absence in patients with musculoskeletal and, or, mental health conditions
22/12/2021	Investigating the conversion rate of routine referrals for patients presenting with symptoms of possible cancer.
20/12/2021	Risk of major adverse cardiovascular events in patients with elevated low-density lipoprotein cholesterol, excluding atherosclerotic cardiovascular disease, atherosclerotic cardiovascular disease -risk equivalent and familial hypercholesterolemia patients
17/12/2021	Healthcare database study to estimate prevalence and healthcare burden of prurigo nodularis
17/12/2021	Effectiveness of glucosamine on mortality and cancer incidence in patients with osteoarthritis
17/12/2021	Assessing the risk of systemic diseases, such as Behcet's, systemic lupus erythematous and inflammatory bowel disease, in children that present to primary care with mouth ulcers.
14/12/2021	The association between medicines and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study
13/12/2021	Covid-19 vaccination in inflammatory conditions treated with immune suppressing drugs: a study of clinical effectiveness and vaccine safety using data from the Clinical Practice Research Datalink (CPRD)
10/12/2021	Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom
10/12/2021	Trends of second-line antidiabetic treatments in adults with type 2 diabetes
10/12/2021	The epidemiology of diseases of the circulatory system in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
07/12/2021	Association between thrombosis with thrombocytopenia syndrome (TTS) or thromboembolic events, and covid-19 vaccines