Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
13/01/2021	Impact of COVID-19 pandemic on routine clinical management of patients with neurological diseases: a descriptive retrospective cohort study
12/01/2021	Incidence, Prevalence of Multiple Sclerosis in CPRD – Burden of Mortality, Infection and Cancer Among Patients With Multiple Sclerosis
08/01/2021	The impact of timely diagnosis and recurrent health seeking behaviour on the subsequent clinical course of Inflammatory Bowel Disease: A UK population based study
07/01/2021	Is there an association between antibiotic exposure and Parkinson disease?
07/01/2021	Prevalence estimate of atherosclerotic cardiovascular disease, atherosclerotic cardiovascular disease -risk equivalent and familial hypercholesterolaemia patients with elevated low-density lipoprotein cholesterol.
06/01/2021	Trends and factors associated with prescription opioid utilisation, dependence and deaths in patients with rheumatic and musculoskeletal diseases
06/01/2021	Understanding clusters and mechanisms of complex multimorbidity in people with common allergic conditions
05/01/2021	A retrospective, observational, real world study to describe the treatment pathway, healthcare resource utilisation, and clinical outcomes in patients with metachromatic leukodystrophy
05/01/2021	A retrospective database analysis to estimate the burden of pneumococcal disease in children 0-17 years in England
18/12/2020	Statin use to mitigate the unwarranted cardiovascular side effects of non-steroidal anti-inflammatory drugs: A population-based case control study
18/12/2020	The use of methylphenidate and the risk of suicide attempt: A population-based self-controlled case series study
18/12/2020	Prevalence, incidence, healthcare resource utilization and costs of myotubular myopathy patients in England
15/12/2020	"A cohort study of mortality in the Clinical Practice Research Datalink (CPRD) primary care database - CPRD Aurum"
15/12/2020	A cohort study of the care home population in CPRD Aurum
15/12/2020	Investigating the effect of cardiovascular risk level on severe outcomes of COVID-19
15/12/2020	Investigating drug-disease relationship through directed graph mapping: interactions, indications and contraindications
15/12/2020	Use and effectiveness of physical activity and dietary based lifestyle interventions for patients with hypertension
11/12/2020	The benefits and side effects of osteoporosis medications: A regression discontinuity study of primary care patients in the UK.
09/12/2020	Distributional and heterogeneous treatment effects of health care interventions for gestational diabetes using regression discontinuity in electronic health record data
08/12/2020	Patterns of multimorbidity, multimorbidity clusters and associations with mortality in patients with intellectual disabilities in the UK.