Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
28/09/2023	Does the cumulative dose of aspirin affect cancer risk
28/09/2023	Predictors of discontinuation or reduction of long-term opioid therapy and its associated adverse events in patients with chronic non-cancer pain in the UK primary care: a retrospective cohort study
28/09/2023	Characterisation and treatment pathways of heavy menstrual bleeding using the Clinical Practice Research Datalink: a descriptive study
27/09/2023	Development and validation of risk scoring tools for acute exacerbations and cardiovascular outcomes among patients with chronic obstructive pulmonary disease (COPD).
27/09/2023	Identifying treatable traits of people with asthma prescribed an Inhaled Corticosteroid and Long Acing Beta-2 Agonist (ICS-LABA) - a descriptive analytic study in England
27/09/2023	Demographic characteristics of a population with obesity, atherosclerotic cardiovascular disease, and no diabetes
25/09/2023	A feasibility study to estimate subgroups of atrial fibrillation population
22/09/2023	An observational study program to investigate the management and consequences of hyperkalemia in cardiorenal patients in routine clinical practice
22/09/2023	Use of systemic fluoroquinolones in the UK: a drug utilisation study
21/09/2023	Artificial intelligence to identify medications in primary care associated with increased risk of keratinocyte skin cancer; an exploratory and nested case control study.
20/09/2023	Linaclotide Safety Study for the Assessment of Diarrhoea Complications and Associated Risk Factors in the UK population with Irritable Bowel Syndrome predominantly with constipation (IBS-C)
20/09/2023	Management of people with asthma in primary care by smoking status: a descriptive cohort study
20/09/2023	A descriptive study measuring the uptake of NICE (National Institute for Health and Care Excellence) guidance on cardiovascular disease risk assessments and lipid lowering therapies for primary and secondary prevention of cardiovascular disease
20/09/2023	Cardiovascular risk with discontinuation of sodium-containing medications after a hypertension diagnosis
18/09/2023	Multi-region evaluation of the national roll out of social prescribing link workers in primary care
15/09/2023	"Cancer prevention, screening, diagnosis and prognosis in people with learning disabilities
14/09/2023	Dental patient encounters in general medical practices: a real-world evidence study
14/09/2023	Reproducibility of estimates of prevalence of rare blood cancers from DARWIN EU in the Clinical Practice Research Datalink from primary care sources and assessing the impact of including hospital derived data
14/09/2023	From symptoms to first acute exacerbation of chronic obstructive pulmonary disease: what has changed over time?
14/09/2023	Long-term real-world effectiveness of glucagon-like peptide-1 receptor agonists compared to dipeptidyl peptidase 4 inhibitors on clinical liver events among individuals with T2D living in England: a longitudinal cohort study