Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
04/08/2023	Risk of suicide events with discontinuation of antidepressant treatment in patients with major depressive disorder.
03/08/2023	Co-prescribing of endothelin receptor antagonists (ERAs) and phosphodiesterate-5 inhibitors (PDE-5is) in pulmonary arterial hypertension (PAH) - a DARWIN EU study
03/08/2023	Management of musculoskeletal pain in ChiLdren and young people wIth Mental health or neurodivergent comorBidity (CLIMB)
31/07/2023	Replication of Efficacy and safety of once-weekly semaglutide 1.0 mg vs once-daily liraglutide 1.2 mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10)
31/07/2023	Quantifying the role of norovirus transmission dynamics in acute kidney injury hospitalisation trends in England: a population level modelling study
31/07/2023	Patients with alpha-1-antitrypsin deficiency and the risk of developing liver events: A longitudinal cohort study
28/07/2023	Predicting smoking pack-years using routinely collected smoking data
27/07/2023	Long COVID and subsequent clinical outcomes: a comparison of patients with and without reporting adverse drug events (ADRs) during primary care consultations
27/07/2023	Age at first diagnosis among people with severe mental illness, and related inequalities in England: a population-based cohort study using primary care (CPRD) data
25/07/2023	Effect of statin deprescription in older patients initiated after a first cerebrovascular event or myocardial infarction on recurrence of cardiovascular events and cardiovascular mortality, a population based cohort study in the CPRD
25/07/2023	Early immunization for influenza and the risk of neurodegenerative disease
24/07/2023	Representativeness of the Clinical Practice Research Datalink (CPRD) primary care databases in relation to wider social determinants of health in the UK Censuses 2011 and 2021-2
24/07/2023	Exploring veterans physical and mental health needs: the use of the Clinical Practice Research Datalink
24/07/2023	Effects of Gastroprotective Agents and Direct Oral Anticoagulant Cotherapy on Gastrointestinal Bleeding, Intracranial Haemorrhage and Embolic Events in Patients with Atrial Fibrillation: Target Trial Emulations using Electronic Health Records
21/07/2023	The efficacy and safety of concomitant treatment with valsartan and indapamide in patients with essential arterial hypertension: Outcomes in real world practice
21/07/2023	Cardiovascular outcomes of gout flares and treat-to-target urate lowering treatment.
21/07/2023	Understanding the associations between major depression and type 2 diabetes: Longitudinal trends in disease progression, care and reciprocal impact using retrospective cohort designs within the Clinical Practice Research Datalink
20/07/2023	Comparing Symbicort with inhaled corticosteroid only in asthmatic adults and adolescents
18/07/2023	Understanding trajectories of healthcare use and costs over the multimorbidity journey: a longitudinal study
18/07/2023	Factors associated with referral to pulmonary rehabilitation and palliative care services in people with diagnosis of idiopathic pulmonary fibrosis