Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
22/12/2023	Incidence, prevalence, and characterisation of medicines with suggested drug shortages in Europe
20/12/2023	Does flucloxacillin increase the risk of stroke and systemic embolism in patients who are already using direct oral anticoagulants?
20/12/2023	Monitoring the prescription in primary care of antibiotics for public health emergencies that may be at risk of shortages in the European Union
20/12/2023	Investigating the impact of SARS-CoV-2 on gastrointestinal illness using advanced linked data systems
20/12/2023	Measuring current practice and inequalities in type 2 diabetes treatment and intensification: a population-based cohort study
19/12/2023	The effect of antiseizure medications on the effectiveness and safety of anticoagulants in patients with stroke: A population-based study in the United Kingdom.
15/12/2023	Benefits and risks of pausing long-term osteoporosis treatment: nested case-control and cohort studies using data from the Clinical Practice Research Datalink.
14/12/2023	Incidence and prevalence of Parkinson's: secular and demographic patterns
08/12/2023	Associations between sociodemographic and environmental factors and cardiovascular disease risk in the UK.
07/12/2023	Antipsychotics and Type 2 Diabetes in Children and Young People: A Population-based Study
07/12/2023	Disease epidemiology and drug utilisation for disease-specific treatments of regulatory interest
07/12/2023	Feasibility study of the occurrence of severe clinical events in steatotic liver disease
05/12/2023	Longitudinal Treatment Patterns, Health Outcomes and Costs of Cancer Associated Thrombosis (CAT) in the United Kingdom: A Real-World Study Using Clinical Practice Research Datalink (CPRD)
01/12/2023	Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)
30/11/2023	Exploring the risk of cardioMetabolic complications and describing healthcare resource utilisation in PeOple living With ovERweight and obesity: a non-interventional retrospective longitudinal study in the UK. (EMPOWER)
30/11/2023	Use of topiramate and risk of glaucoma: a case-control study in UK primary care
30/11/2023	Burden, risk and trends of non-communicable diseases, mortality and hospitalisation among people living with HIV compared to people without HIV
30/11/2023	Understanding the hip and knee osteoarthritis-arthroplasty pathway and improving Day Case Arthroplasty patient selection
30/11/2023	Clinical characteristics, outcomes and disease trajectories for patients with incident atrial fibrillation
28/11/2023	Incidence of stroke in patients with epilepsy using anti-seizure medication in England: A retrospective cohort study conducted within the Clinical Practice Research Datalink (CPRD)