Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
24/03/2021	The impact of systemic corticosteroids on diabetes mellitus and osteoporosis in adults: a retrospective cohort study
23/03/2021	The Impact of COVID-19 lockdown on the lives of People with Obesity (PwO): A UK primary care based study
23/03/2021	Evaluating the risk of incident cardiovascular disease and cardiovascular drug prescribing patterns in patients with liver disease
22/03/2021	Outcomes of maternal epilepsy and antiepileptic medications during pregnancy (PREPArE)
18/03/2021	A Case Control and Cohort Design Study, using Multi-state Models, Analysis of Treatment Patterns in Chronic Obstructive Pulmonary Disease and Asthma.
18/03/2021	The impact of area level deprivation and geographical variation on survival and resource use in patients with colorectal, gastro-oesophageal, lung or ovarian cancer in England.
18/03/2021	Burden of Disease and Treatment Patterns for Patients with Hip and Knee Osteoarthritis in the United Kingdom
18/03/2021	Natural history of disease and real-world health outcomes of patients with Fabry disease in the UK
17/03/2021	Can we use routinely collected primary care medical records to assess and explain variations in major lower extremity amputation rates across the England?
16/03/2021	The development of risk-stratified blood-test monitoring strategies for common inflammatory conditions treated with immune suppressing drugs
16/03/2021	Healthcare utilisation, symptoms, prescriptions and new disease in people with COVID-19 managed in the community or hospital.
16/03/2021	Influence of safety advisories on drug utilization: interrupted time series and cohort studies
16/03/2021	Prevalence and healthcare utilization of patients with Eosinophilic granulomatosis with polyangiitis (EGPA) in the Clinical Practice Research Datalink database
16/03/2021	The effect of metformin on health outcomes in routine care: a regression discontinuity analysis.
12/03/2021	Characterising the young chronic obstructive pulmonary disease (COPD) patient in the United Kingdom: A descriptive study looking at clinical and aetiological factors utilising Clinical Practice Research Datalink (CPRD)
09/03/2021	CORYLUS UK: A retrospective observational cohort study of the impact of COVID-19 on systemic lupus erythematosus patients in England using data from linked primary and secondary care databases
09/03/2021	Respiratory Syncytial Virus (RSV) infections in England: estimating the burden of antibiotic prescriptions, healthcare utilisation and associated costs.
08/03/2021	WEiGht changes, caRdio-metabolic risks and mortality in patients with hypErThyroidism; all-cohort natural history and comparison of treatment effects in a CPRD-HES linked study. EGRET study
04/03/2021	Influence of allopurinol in addition to colchicine on Major Adverse Cardiac Events (MACE): a retrospective population-based cohort study
03/03/2021	Temporal trends in the incidence of common mental disorders in the United Kingdom by sociodemographic group (2000-2020)