Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
22/02/2021	The direct and indirect effects of Covid-19 on long-term conditions: A retrospective cohort study using primary and secondary care electronic health records
18/02/2021	Effectiveness and safety of apixaban vs rivaroxaban in patients with Atrial Fibrillation and Diabetes Mellitus
18/02/2021	The effect of treatment intensification for type 2 diabetes on health outcomes in routine care and across highly granular patient subgroups: a regression discontinuity analysis
16/02/2021	Prognostic significance of initiating loop diuretics and its relationship to heart failure
16/02/2021	Association between weight loss and fertility in women diagnosed with polycystic ovary syndrome and living with overweight or obesity
15/02/2021	Investigating whether in utero exposure to maternal psychotropic medication is associated with adverse pregnancy outcomes and adverse health and neurodevelopmental outcomes in offspring
15/02/2021	Sulfonylureas versus metformin as initial treatment for type 2 diabetes and the risk of ventricular arrhythmia: A population-based cohort study
11/02/2021	COVID-19 recording in Clinical Practice Research Datalink primary care data and linked Second Generation Surveillance System SARS-CoV-2 virology test data
11/02/2021	Moderating effects of intellectual disabilities on mortality among people with autism: a retrospective cohort study of a national sample of primary-care patients in England using the Clinical Practice Research Datalink
10/02/2021	Risk of tendon disorders and Psoriatic arthritis with fluoroquinolone prescriptions in Psoriasis patients
09/02/2021	A study to assess the feasibility of using CPRD-HES linked data to describe the clinical and economic burden of haemophilia in England.
09/02/2021	Association between weight loss and healthcare resource utilization in adults living with obesity
09/02/2021	Evaluation of prostate cancer treatments, cardiovascular disease risk, and de novo diabetes or diabetes worsening in metastatic castration resistant prostate cancer patients treated with abiraterone acetate compared with enzalutamide in England.
02/02/2021	Real world evidence in asthma and chronic obstructive pulmonary disease to understand the burden of COVID-19 infection in United Kingdom
02/02/2021	Overactive bladder anticholinergics and risk of incident dementia: a cohort study design using a triangulation approach
01/02/2021	Developing personalised risk prediction for women at increased risk of Vulval Cancer
29/01/2021	Prediction of significant bleeding during anticoagulant use in patients with cancer-related venous thromboembolism: an English cohort study.
29/01/2021	Assessing the quality and uptake of incentivised physical health checks for people with serious mental illness
29/01/2021	A machine learning approach to classify types of headache from laboratory blood test results
29/01/2021	Risk of Abnormal Uterine Bleeding associated with direct oral anticoagulants compared with Vitamin K antagonists