Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
02/02/2021	Real world evidence in asthma and chronic obstructive pulmonary disease to understand the burden of COVID-19 infection in United Kingdom
01/02/2021	Developing personalised risk prediction for women at increased risk of Vulval Cancer
29/01/2021	A machine learning approach to classify types of headache from laboratory blood test results
29/01/2021	Risk of Abnormal Uterine Bleeding associated with direct oral anticoagulants compared with Vitamin K antagonists
29/01/2021	Prediction of significant bleeding during anticoagulant use in patients with cancer-related venous thromboembolism: an English cohort study.
29/01/2021	Assessing the quality and uptake of incentivised physical health checks for people with serious mental illness
28/01/2021	Understanding associations between cardiometabolic and cardiac health, and risk of dementia
27/01/2021	Incidence and prevalence of heart failure in patients with idiopathic pulmonary fibrosis (IPF) between 2010 - 2019 and the impact of heart failure treatment on IPF mortality: a population-based study using CPRD Aurum
26/01/2021	Multimorbidity and health care outcomes in patients with Rheumatoid Arthritis and Psoriatic Arthritis
26/01/2021	Urban-rural comparison of access to care and health outcomes for five major health conditions related to cardio-metabolic diseases, mental health and infectious diseases in England
26/01/2021	Investigating epilepsy-related mortality among children and young people with intellectual disabilities and co-occurring epilepsy: a record linkage cohort study
25/01/2021	Prevalence and incidence of mental health conditions in children and young people with intellectual disabilities in England
21/01/2021	Trends of gabapentinoid prescribing associated overdose and mortality in chronic pain patients and the impact of gabapentinoid classification as a controlled drug
21/01/2021	Cohort study of risk factors of acute and chronic cardiovascular events in COVID-19 patients
19/01/2021	The descriptive epidemiology of Adverse Events of Special Interest for COVID-19 and other vaccines in the general population and after seasonal influenza and COVID-19 disease
19/01/2021	Use of renin-angiotensin-aldosterone system inhibitors and the risk of acute pancreatitis
18/01/2021	Direct oral anticoagulants (DOAC) dosing patients with non-valvular atrial fibrillation (NVAF): a retrospective cohort study using the Clinical Practice Research Datalink (CPRD) Gold database
15/01/2021	Comparability and Relative Effectiveness of Osteoporosis Treatment Groups in European Clinical Practice
15/01/2021	Diagnosing COPD: Survey of Patient Experience across the UK
15/01/2021	Comorbidity among patients receiving opioid substitution therapy: examination of primary and secondary healthcare utilisation, cost of care, drug-drug interactions and mortality risk.