Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
22/08/2023	Global COVID Vaccine Safety (GCoVS) Project Investigating COVID-19 Vaccination and Adverse Events, including Myocarditis, Pericarditis, Guillain-Barre Syndrome and Vaccine Induced Thrombosis and Thrombocytopenia: A Self-controlled case series study.
21/08/2023	Feasibility Study to Assess the Recording of Endocrine Therapy Use and Induced Vasomotor Symptoms among Women with Breast Cancer in the UK
16/08/2023	Understanding and addressing socio-economic inequality within the quality and safety of care and outcomes for people living with dementia.
15/08/2023	Chronic pain and opioid prescribing in the local health economy: the trends in prevalence and incidence and associated healthcare resource utilisation
15/08/2023	Feasibility and assessment of the association between opioid use and the development of diverticulitis
14/08/2023	Vascular disease and cancer: cohort studies of adult cancer populations and outcomes
10/08/2023	Enhancing Autism Spectrum Disorder (ASD) Research in the United Kingdom: Prevalence Estimation and Comparative Assessment of Conventional Regression and Machine Learning Models for ASD Risk Prediction
09/08/2023	A treat to target approach for obesity management: exploring potential treatment targets
09/08/2023	The risk of adverse psychiatric and somatic outcomes with gabapentinoid use: a UK population-based study using electronic health records
09/08/2023	Adverse health outcomes among people with atopic eczema: a consistent application of cohort study design to multiple outcomes
09/08/2023	The association between hyperglycaemia and hypertension during pregnancy and their impact on maternal health and birth outcomes- a retrospective cohort study in the CPRD database
08/08/2023	The association between prescriptions for inhaled corticosteroids, pneumonia and exacerbations in people with asthma and Chronic obstructive pulmonary disease
04/08/2023	The efficacy and safety of concomitant treatment with candesartan and indapamide in patients with essential arterial hypertension: Outcomes in real world practice
04/08/2023	Risk of suicide events with discontinuation of antidepressant treatment in patients with major depressive disorder.
03/08/2023	Management of musculoskeletal pain in ChiLdren and young people wIth Mental health or neurodivergent comorBidity (CLIMB)
03/08/2023	Co-prescribing of endothelin receptor antagonists (ERAs) and phosphodiesterate-5 inhibitors (PDE-5is) in pulmonary arterial hypertension (PAH) - a DARWIN EU study
31/07/2023	Replication of Efficacy and safety of once-weekly semaglutide 1.0 mg vs once-daily liraglutide 1.2 mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10)
31/07/2023	Patients with alpha-1-antitrypsin deficiency and the risk of developing liver events: A longitudinal cohort study
31/07/2023	Quantifying the role of norovirus transmission dynamics in acute kidney injury hospitalisation trends in England: a population level modelling study
28/07/2023	Predicting smoking pack-years using routinely collected smoking data