Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Changes in cause of mortality over time in people with chronic respiratory disease in the UK
Burden of Multiple Myeloma (MM) in England: regional equity based on Real world data from CPRD HES, and Cancer Registry linked data.
Association between HbA1c and all-cause mortality in people with type 2 diabetes treated with glucose-lowering therapies with a higher and lower risk of inducing hypoglycaemia: a retrospective cohort study.
Generalizability of Clinical Trial Results: Value of Individual Data versus Aggregate Data
Immunosuppressive therapy and Parkinson's disease risk
Safety and associated costs of glucocorticoid therapy for the treatment of chronic inflammatory diseases
Impact of hospital admission upon patterns of primary care prescribing
Use of hormone replacement therapy and risk of breast cancer
Risk of developing chronic obstructive pulmonary disease or lung cancer in smokers taking enzyme-inducing antiepileptic drugs
Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU
Study to investigate the drug treatment for sialorrhoea in children over the past 10 years.
Assessing the Management and Clinical Outcomes of Patients with Non-Diabetic Intermediate Hyperglycaemia in UK Primary Care
Hyperglycaemia and early detection of pancreatic cancer
The incidence of Guillain-Barre Syndrome in the United Kingdom from April 2005 to March 2015.
Cancer Survival Programme and Early Diagnosis of Cancer
An analytical framework for increasing the efficiency and validity of research using primary care databases
Proton pump inhibitors and kidney disease: a self-controlled case series and cohort study
Rates of cytomegalovirus among children with organ transplants
Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
Treatment of acute lower respiratory tract infections in patients with and without asthma