Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
24/01/2024	Apixaban Dosing and Clinical Outcomes for Patients with Non-valvular Atrial Fibrillation or Venous Thromboembolism
24/01/2024	Nonsteroidal anti-inflammatory drugs use in gout and the risk of skin ulcer
24/01/2024	Exploring the Impact of Frailty Status on the Relationship Between Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2Is) and Adverse Cardiovascular Outcomes in Older People with Type 2 Diabetes
26/01/2024	The effect of major adverse cardiovascular events in people with Chronic Obstructive Pulmonary Disease (COPD) on future COPD exacerbations, future cardiovascular events, and mortality
26/01/2024	Optimising Structured Medication Reviews for Older People with Severe Frailty and Care Home Residents to Reduce Over-prescribing and Associated Inequalities
26/01/2024	The effect of diabetes medications on chronic lung disease: a population-cohort study
29/01/2024	Quantifying the impact of the COVID-19 pandemic and the Kidney Failure Risk Equation on Chronic Kidney Disease care and outcomes in Primary Care
29/01/2024	Epidemiology of Amyloidosis in the UK: A Retrospective Cohort Study using Clinical Practice Research Data Link (CPRD)
29/01/2024	Establishing the baseline data to support research for the prevention of primary diabetic foot ulcers
29/01/2024	Understanding and Preventing Epilepsy Inequalities in the UK
31/01/2024	Exploring the impact of a drug safety update on the use of dapagliflozin in type 1 diabetes mellitus
31/01/2024	Epidemiology of intraoperative and postoperative complications in patients undergoing left-sided colorectal surgery for benign or malignant colorectal disease in England
31/01/2024	Clinical outcomes and health resource use in people with controlled and uncontrolled chronic obstructive pulmonary disease (COPD)
06/02/2024	Effectiveness of COVID-19 vaccines on severe COVID-19 and post-acute cardiovascular events and diabetes following SARS-CoV-2 infection: A cohort study
06/02/2024	Exogenous sex steroid hormones and asthma phenotypes: a population-based prospective cohort study using UK-wide primary care data
06/02/2024	Incidence, healthcare resource utilisation and mortality of invasive fungal infections (IFI) in hospitalised paediatric patients with and without ever having had an IFI-related hospitalisation in England
08/02/2024	Prescribing of Opioids in Menopausal and Postmenopausal Women in the UK: A Population-based Drug Utilization Study
08/02/2024	The efficacy and safety of concomitant treatment with dapagliflozin and sitagliptin in patients with type II diabetes: Outcomes in real world practice.
08/02/2024	Use of treatments for bipolar disorder in pregnancy and risk of congenital anomalies and developmental disorders in offspring
01/03/2024	COVID-19 booster vaccine effectiveness in secondary prevention of major adverse cardiovascular events: an emulated target trial in observational data