Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Rates of cytomegalovirus among children with organ transplants
Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
Risk of developing chronic obstructive pulmonary disease or lung cancer in smokers taking enzyme-inducing antiepileptic drugs
Characterising the risk of major bleeding in patients with Non-Valvular Atrial Fibrillation: non-interventional study of patients taking Direct Oral Anticoagulants in the EU
Study to investigate the drug treatment for sialorrhoea in children over the past 10 years.
Assessing the Management and Clinical Outcomes of Patients with Non-Diabetic Intermediate Hyperglycaemia in UK Primary Care
Hyperglycaemia and early detection of pancreatic cancer
The risk of cardiovascular related death following cytomegalovirus (CMV) infection in England: an open cohort study using data from the Clinical Practice Research Datalink (CPRD)
Long-term outcomes of NHS Health Checks in England.
Unsupervised clustering and topological analysis of Type-2 Diabetes and prediabetes patients in CALIBER using clinical data from electronic medical records
Changes in lung function (FEV1) over time in a primary care COPD cohort
Estimating the effect of statin and metformin on cancer incidence and mortality in national linked electronic health records: a CALIBER study
The Use of Angiotensin Converting Enzyme Inhibitors and the Risk of Lung Cancer
Treatment of acute lower respiratory tract infections in patients with and without asthma
Comorbidity as a predictor of referral to, and outcome from, joint replacement surgery in primary care patients with newly diagnosed arthritis: a population-based cohort study
Are primary care consultations about insomnia associated with later dementia?
Post-authorization Safety Study: Evaluation of Cardiovascular Events in Users of Mirabegron and Other Treatments for Overactive Bladder in the CPRD
Dipeptidyl deptidase-4 inhibitors and the incidence of inflammatory bowel disease among patients with type 2 diabetes.
A study of multifactorial intervention in type 2 diabetes and chronic kidney disease
Association between Diabetes Mellitus and Incident Meniere's Disease