Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Approved studies using CPRD Data

Date of Approval Sort descending Title
Trends in NHS prescribing of dual NRT (DNRT) and varenicline in pregnancy and effects on infants
Hypoglycaemia and serious adverse events in older people living with diabetes and dementia – a population-based cohort study
Predictive value of cancer for dementia in cohorts with and without T2DM: a national observational study
Non-specific effects of vaccination in England
Interruption of Renin-Angiotensin-Aldosterone System Inhibition Treatment and Associations with Adverse Outcomes
Quantification of the association between chronic kidney disease status and cause-specific hospitalisation: a population-based cohort study in the UK
Effects of financially-induced inhaler switching on the risk of an acute exacerbation in patients with asthma or chronic obstructive pulmonary disease (COPD): a self-controlled case series
The association between chronic kidney disease and tuberculosis; a comparative cohort study in England
Cardiovascular Disease Risk Prediction Screening Using Electronic Health Records
Secondary prevention of acute coronary syndrome: comparative effectiveness of recommended vs. less intensive drug combination using Clinical Practice Research Datalink (CPRD). The SCARFACE-CPRD study.
Novel Prediction Models for the One-Year Competing Risks of Death, Stroke, Intracranial Hemorrhage, and Extracranial Hemorrhage in Adults with Incident Non-Valvular Atrial Fibrillation
An epidemiological study of Antiphospholipid Syndrome using electronic health records
Disease burden of diabetes patients with high dose insulin treatment in CPRD
Urinary tract infections in the elderly - care pathways and characteristics
Comparative effectiveness of lansoprazole and omeprazole for the prevention of gastrointestinal bleeding and malignancy
Primary Care and Access To Surgical Treatment For Women With Urinary Incontinence
Association between glycated hemoglobin (HbA1c), weight and hypoglycemia to treatment choice and medication adherence in Type 2 Diabetes Mellitus (T2DM)
Incidence of liver failure and non-viral hepatitis in Multiple Sclerosis (MS) patients and in the general population - a study using the CPRD
Estimating heterogeneous treatment effects from routinely collected health data: A case study on anticoagulant therapy for atrial fibrillation patients.
The impact of polypharmacy on health outcomes in older patients: a retrospective cohort study using CPRD database.