Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/11/2018	Disease Burden and Health Care Utilisation and Costs among Patients with Nonalcoholic Steatohepatitis (NASH) and Nonalcoholic Fatty Liver Disease (NAFLD)
19/11/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 18-Replication of "Risk of Myocardial infarction in Patients with Atrial Fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants"
20/11/2018	Feasibility study to assess identification of the care home residency population from CPRD
21/11/2018	Missed opportunities for limb salvage in patients undergoing major amputation - a retrospective cohort study of the clinical practice research datalink
21/11/2018	The prevalence of co-prescribing of tramadol and antidepressants during 1998-2017, and associated risk of all-cause mortality and emergency hospital admissions
22/11/2018	Trends in the prescribing of opioids for non-malignant pain in UK primary care: a descriptive study
26/11/2018	The impact of knee replacement on mortality in the presence of chronic disease
26/11/2018	Incidence and management of sudden sensorineural hearing loss in primary and secondary care
28/11/2018	An impact evaluation of the Joint Royal College of General Practitioners (RCGP)-Clinical Practice Research Datalink (CPRD) quality improvement initiative
28/11/2018	Burden of disease in patients with Chronic Obstructive Pulmonary Disease (COPD)
28/11/2018	Bone pain in primary care patients newly diagnosed with multiple myeloma: a population-based cohort study
30/11/2018	Prescriptions for antibiotics in childhood and risk of inflammatory bowel disease: A matched case-control study in the UK Clinical Practice Research Datalink
30/11/2018	Clusters of Chronic Obstructive Pulmonary Disease (COPD) co-morbidities and their relevance to mortality, service use, age and socioeconomic status.
30/11/2018	REPEAT Study 17 - Replication of "Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study"
05/12/2018	Blood eosinophil levels as independent risk factor of severe asthma exacerbations and mortality in adult patients with asthma
05/12/2018	Fibrosing lung diseases: determinants, prognosis, and disease prediction
05/12/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 20 - Replication of "Risk of Death and Cardiovascular Outcomes with Thiazolidinediones: A Study with the General Practice Research Database and Secondary Care Data"
11/12/2018	Identifying population groups at risk of avoidable hospitalisations for community acquired pneumonia in the UK.
11/12/2018	Evaluating the risk of macrovascular events, disability, and mortality in individuals with multiple sclerosis in England: a population-based retrospective cohort study
11/12/2018	Mental illness: changes in incidence, prevalence, treatment and outcomes 2000-2018