Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
23/01/2017	Effects of changing pre-eclampsia management on acute renal failure and other maternal and perinatal outcomes in the United Kingdom: An interrupted time-series analysis
26/01/2017	Developing Personalised Renal Function Monitoring for Heart Failure Patients
26/01/2017	Clinical burden of illness and healthcare resource utilisation among COPD patients stratified by their moderate-severe exacerbation frequency, inhaled triple maintenance treatment status and blood eosinophil levels
26/01/2017	Investigation of the comparative safety of opioid drugs within CPRD- part of the International Pharmacosurveillance Study
01/02/2017	Assessment of the rate of vaccine co-administrations with Bexsero
01/02/2017	The risk of cardiovascular diseases among survivors of site-specific adult cancers: a matched cohort study
01/02/2017	Investigating the impact of BMI of patient with type 2 diabetes on length and cost of hospital stay for complications related to diabetes.
01/02/2017	Association between Rheumatoid Arthritis and comorbidities: a combined retrospective case-control and prospective cohort study.
01/02/2017	The Risks of Mortality, Cardiovascular Events, and Diabetes Associated With Statin Use In Patients With Rheumatoid Arthritis
01/02/2017	Unintended effects of zaleplon, zolpidem, zopiclone (Z-drugs) use for sleep disturbance in people with dementia
02/02/2017	A Drug Utilisation Study of domperidone in the United Kingdom using Clinical Practice Research Datalink (CPRD)
14/02/2017	Extreme restriction design as a method for removing confounding by indication in pharmacoepidemiologic research
14/02/2017	Comparative effectiveness and safety of novel oral anticoagulants in atrial fibrillation
14/02/2017	Non-specific effects of vaccination in England
14/02/2017	Trajectories of metabolic and clinical parameters prior to the onset of dementia in people with Type 2 diabetes
14/02/2017	The effect of month of birth on the risk of being diagnosed with learning disability and depression.
14/02/2017	Evaluation of the risk of intracranial and gastrointestinal bleeding events in patients concurrently prescribed non-steroidal anti-inflammatory drugs and SSRI antidepressants.
14/02/2017	Potentially inappropriate prescribing in people with dementia in England: a prospective cohort study.
14/02/2017	The role of the microbiome in joint and bone disease
14/02/2017	Developing a co-morbidity tool to predict mortality for linked primary and secondary care data.