Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
26/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 2 - Replication of "Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study"
28/03/2018	Predicting Type-II Diabetes Using Primary Care information
28/03/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 8 - Replication of "Incidence of type 2 diabetes after bariatric surgery"
28/03/2018	Utilisation pattern of hormonal replacement therapy in UK general practice between 2000 and 2016
28/03/2018	A Comparison of the Effectiveness and Safety of Direct Oral Anticoagulants (DOACs) versus. Warfarin in Older People with Atrial Fibrillation
03/04/2018	Heart failure as a risk factor for acute exacerbations of COPD (AECOPD)
03/04/2018	REPEAT: Study 9- Replication of "Can analyses of electronic patient records be independently and externally validated? The effect of statins on the mortality of patients with ischaemic heart disease: a cohort study with nested case-control analysis"
03/04/2018	Improving care and cardiovascular health status for adults with osteoarthritis at risk of cardiovascular disease
03/04/2018	Healthcare resource utilisation associated with hepatocellular carcinoma in the UK
03/04/2018	Individual-level cost-of-illness Analysis for FoResight and Modelling for European HEalth Policy and Regulation (FRESHER) Project using linked English Data
05/04/2018	Comparison of Outcomes for Patients Hospitalised for Heart Failure (HHF) in the UK, Japan, USA and Taiwan
05/04/2018	Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with coronary artery disease (CAD), peripheral artery disease (PAD), and CAD or PAD
05/04/2018	Epidemiology, outcomes, treatment patterns, and health resource utilization among English patients with Congestive heart failure (CHF), and patients with CAD and CHF
05/04/2018	Gabapentinoid drug prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink
05/04/2018	Abdominal pain in primary care: establishing a clinical profile and diagnostic pathway for identifying cancer
06/04/2018	Weight change and the onset and progression of cardiovascular diseases in large scale electronic health records
09/04/2018	Understanding the physical harms associated with the use of combined antipsychotic medication in people with schizophrenia
11/04/2018	Utilisation of Ulipristal acetate 5mg, long-term treatment patterns, resource utilisation in a population-based cohort in UK using the THIN and CPRD databases
11/04/2018	Epidemiology of amyloidosis in the United Kingdom
18/04/2018	Pharmaco-Epidemiological Study of Cardio-Respiratory Safety of Beta2-agonists for the Treatment and Management of Asthma-COPD Overlap Syndrome