Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,300 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 4 September 2019) and papers are listed below and in the PDF below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


(PDF, 3MB, 189 pages)


Export 2324 results:
Author Title Type [ Year(Asc)]
D. Yu, Jordan, K. P., Bedson, J., Englund, M., Blyth, F., Turkiewicz, A., Prieto-Alhambra, D., and Peat, G., Population trends in the incidence and initial management of osteoarthritis: age-period-cohort analysis of the Clinical Practice Research Datalink, 1992-2013, Rheumatology (Oxford), vol. 56, pp. 1902-1917, 2017.
S. G. Bruderer, Bodmer, D., Stohler, N. A., Jick, S. S., and Meier, C. R., Population-Based Study on the Epidemiology of Meniere's Disease, Audiol Neurootol, vol. 22, pp. 74-82, 2017.
L. V. Re, Carbonari, D. M., Saine, M. E., Newcomb, C. W., Roy, J. A., Liu, Q., Wu, Q., Cardillo, S., Haynes, K., Kimmel, S. E., Reese, P. P., Margolis, D. J., Apter, A. J., Reddy, K. R., Hennessy, S., Bhullar, H., Gallagher, A. M., Esposito, D. B., and Strom, B. L., Postauthorization safety study of the DPP-4 inhibitor saxagliptin: a large-scale multinational family of cohort studies of five outcomes, BMJ Open Diabetes Res Care, vol. 5, p. e000400, 2017.
M. J. Carr, Ashcroft, D. M., Kontopantelis, E., While, D., Awenat, Y., Cooper, J., Chew-Graham, C., Kapur, N., and Webb, R. T., Premature Death Among Primary Care Patients With a History of Self-Harm, Ann Fam Med, vol. 15, pp. 246-254, 2017.
A. L. Nightingale, Davidson, J. E., Molta, C. T., Kan, H. J., and McHugh, N. J., Presentation of SLE in UK primary care using the Clinical Practice Research Datalink, Lupus Sci Med, vol. 4, p. e000172, 2017.
A. J. M. Cooper, Willis, J., Fuller, J., Benecke, H., Leighton-Scott, J., Andersohn, F., Kim, J., Maier, C., and Knaggs, R. D., Prevalence and Incidence Trends for Diagnosed Prescription Opioid Use Disorders in the United Kingdom, Pain Ther, vol. 6, pp. 73-84, 2017.
B. Mars, Heron, J., Gunnell, D., Martin, R. M., Thomas, K. H., and Kessler, D., Prevalence and patterns of antidepressant switching amongst primary care patients in the UK, J Psychopharmacol, vol. 31, pp. 553-560, 2017.
S. E. Holden, Jenkins-Jones, S., Morgan, C. L., Peters, J. R., Schernthaner, G., and Currie, C. J., Prevalence, glucose control and relative survival of people with Type 2 diabetes in the UK from 1991 to 2013, Diabet Med, vol. 34, pp. 770-780, 2017.
M. Iwagami, Tomlinson, L. A., Mansfield, K. E., McDonald, H. I., Smeeth, L., and Nitsch, D., Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, vol. 26, pp. 792-801, 2017.
S. Jick, Li, L., Gastanaga, V. M., Liede, A., and Hernandez, R. K., Prevalence of hypercalcemia of malignancy among pediatric cancer patients in the UK Clinical Practice Research Datalink database, Clin Epidemiol, vol. 9, pp. 339-343, 2017.
S. Suissa, Moodie, E. E., and Dell'Aniello, S., Prevalent new-user cohort designs for comparative drug effect studies by time-conditional propensity scores, Pharmacoepidemiol Drug Saf, vol. 26, pp. 459-468, 2017.
N. Arden, Altman, D., Beard, D., Carr, A., Clarke, N., Collins, G., Cooper, C., Culliford, D., Delmestri, A., Garden, S., Griffin, T., Javaid, K., Judge, A., Latham, J., Mullee, M., Murray, D., Ogundimu, E., Pinedo-Villanueva, R., Price, A., Prieto-Alhambra, D., and Raftery, J., Programme Grants for Applied Research, in Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study, Southampton (UK): NIHR Journals Library Copyright (c) Queen's Printer and Controller of HMSO 2017. This work was produced by Arden et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the pu, 2017.
A. J. Klil-Drori, Yin, H., Abenhaim, H. A., Fort, G. G. du, and Azoulay, L., Prolactin-Elevating Antipsychotics and the Risk of Endometrial Cancer, J Clin Psychiatry, vol. 78, pp. 714-719, 2017.
G. J. Young, Harrison, S., Turner, E. L., Walsh, E. I., Oliver, S. E., Ben-Shlomo, Y., Evans, S., Lane, J. A., Neal, D. E., Hamdy, F. C., Donovan, J. L., Martin, R. M., and Metcalfe, C., Prostate-specific antigen (PSA) testing of men in UK general practice: a 10-year longitudinal cohort study, BMJ Open, vol. 7, p. e017729, 2017.
A. Judge, Garriga, C., Arden, N. K., Lovestone, S., Prieto-Alhambra, D., Cooper, C., and Edwards, C. J., Protective effect of antirheumatic drugs on dementia in rheumatoid arthritis patients, Alzheimers Dement (N Y), vol. 3, pp. 612-621, 2017.
G. Bouras, Markar, S. R., Burns, E. M., Huddy, J. R., Bottle, A., Athanasiou, T., Darzi, A., and Hanna, G. B., The psychological impact of symptoms related to esophagogastric cancer resection presenting in primary care: A national linked database study, Eur J Surg Oncol, vol. 43, pp. 454-460, 2017.
A. R. Tate, Dungey, S., Glew, S., Beloff, N., Williams, R., and Williams, T., Quality of recording of diabetes in the UK: how does the GP's method of coding clinical data affect incidence estimates? Cross-sectional study using the CPRD database, BMJ Open, vol. 7, p. e012905, 2017.
K. Wing, Bhaskaran, K., Pealing, L., Root, A., Smeeth, L., van Staa, T. P., Klungel, O. H., Reynolds, R. F., and Douglas, I., Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study, J Antimicrob Chemother, vol. 72, pp. 2636-2646, 2017.
J. H. Humphreys, Warner, A., Costello, R., Lunt, M., Verstappen, S. M. M., and Dixon, W. G., Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate, Ann Rheum Dis, vol. 76, pp. 1509-1514, 2017.
S. Weir, Samnaliev, M., Kuo, T. - C., Choitir, C. N., Tierney, T. S., Taylor, R. S., Manca, A., Bruce, J., Cumming, D., and Eldabe, S., The rate of persistent post-operative pain (FBSS) in revision lumbar spinal surgery, The Spine Journal, vol. 17, p. S10, 2017.
J. van Boven, Benhaddi, H., Roche, N., Bjermer, L., Miravitlles, M., Voorham, J., and Price, D., Real-world cost effectiveness comparison of symbicort turbuhaler and duoresp spiromax in UK patients with asthma or chronic obstructive pulmonary disease, Value in Health, vol. 20, p. A645, 2017.
D. Lambrelli, Merinopoulou, E., Donaldson, R., Mardekian, J., Hlavacek, P., Tarasenko, L., Masseria, C., and Hobbs, F. D., Real-world treatment patterns among patients initiating on statins in England, Value in Health, vol. 20, pp. A630-631, 2017.
S. Kiconco, A. Sultan, A., and Grainge, M. J., Recurrence risk of venous thromboembolism and hormone use in women from England: a cohort study using clinical practice research datalink, Br J Haematol, vol. 177, pp. 127-135, 2017.
D. A. Springate, Parisi, R., Olier, I., Reeves, D., and Kontopantelis, E., rEHR: An R package for manipulating and analysing Electronic Health Record data, PLoS One, vol. 12, p. e0171784, 2017.
A. Viswanathan, Spera, C., Mullins, A., Covert, D., Banhazi, J., McDwyer, P., Hudson, E., and Ferreira, A., Resource Utilization Among Glaucoma Patients in the UK Treated with Beta-Blocker and Non-Beta-Blocker Adjunctive Therapy: A Retrospective Cohort Analysis, Adv Ther, vol. 34, pp. 1695-1706, 2017.
D. R. Morales, Lipworth, B. J., Donnan, P. T., Jackson, C., and Guthrie, B., Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study, BMC Med, vol. 15, p. 18, 2017.
B. Doble, Payne, R., Harshfield, A., and Wilson, E. C. F., Retrospective, multicohort analysis of the Clinical Practice Research Datalink (CPRD) to determine differences in the cost of medication wastage, dispensing fees and prescriber time of issuing either short (<60 days) or long (>/=60 days) prescription leng, BMJ Open, vol. 7, p. e019382, 2017.
A. Abhishek, Doherty, M., Kuo, C. F., Mallen, C. D., Zhang, W., and Grainge, M. J., Rheumatoid arthritis is getting less frequent-results of a nationwide population-based cohort study, Rheumatology (Oxford), vol. 56, pp. 736-744, 2017.
A. Jain, McDonald, H. I., Nitsch, D., Tomlinson, L., and Thomas, S. L., Risk factors for developing acute kidney injury in older people with diabetes and community-acquired pneumonia: a population-based UK cohort study, BMC Nephrol, vol. 18, p. 142, 2017.
E. Berni, de Voogd, H., Halcox, J. P., Butler, C. C., Bannister, C. A., Jenkins-Jones, S., Jones, B., Ouwens, M., and Currie, C. J., Risk of cardiovascular events, arrhythmia and all-cause mortality associated with clarithromycin versus alternative antibiotics prescribed for respiratory tract infections: a retrospective cohort study, BMJ Open, vol. 7, p. e013398, 2017.
S. Walker and Hamilton, W., Risk of cervical cancer in symptomatic women aged >/=40 in primary care: A case-control study using electronic records, Eur J Cancer Care (Engl), vol. 26, 2017.
D. C. Braeken, Rohde, G. G., Franssen, F. M., Driessen, J. H., van Staa, T. P., Souverein, P. C., Wouters, E. F., and de Vries, F., Risk of community-acquired pneumonia in chronic obstructive pulmonary disease stratified by smoking status: a population-based cohort study in the United Kingdom, Int J Chron Obstruct Pulmon Dis, vol. 12, pp. 2425-2432, 2017.
K. W. Hagberg, Divan, H. A., Fang, S. C., Nickel, J. C., and Jick, S. S., Risk of gynecomastia and breast cancer associated with the use of 5-alpha reductase inhibitors for benign prostatic hyperplasia, Clin Epidemiol, vol. 9, pp. 83-91, 2017.
J. West, Card, T. R., Aithal, G. P., and Fleming, K. M., Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study, Aliment Pharmacol Ther, vol. 45, pp. 983-990, 2017.
K. W. Hagberg, Divan, H. A., Nickel, J. C., and Jick, S. S., Risk of Incident Antidepressant-Treated Depression Associated with Use of 5alpha-Reductase Inhibitors Compared with Use of alpha-Blockers in Men with Benign Prostatic Hyperplasia: A Population-Based Study Using the Clinical Practice Research Datalink, Pharmacotherapy, vol. 37, pp. 517-527, 2017.
B. Spaetgens, de Vries, F., Driessen, J. H. M., Leufkens, H. G., Souverein, P. C., Boonen, A., van der Meer, J. W. M., and Joosten, L. A. B., Risk of infections in patients with gout: a population-based cohort study, Sci Rep, vol. 7, p. 1429, 2017.
E. M. Gieling, van den Ham, H. A., van Onzenoort, H., Bos, J., Kramers, C., de Boer, A., de Vries, F., and Burden, A. M., Risk of major bleeding and stroke associated with the use of vitamin K antagonists, nonvitamin K antagonist oral anticoagulants and aspirin in patients with atrial fibrillation: a cohort study, Br J Clin Pharmacol, vol. 83, pp. 1844-1859, 2017.
L. M. Stolk, de Vries, F., Ebbelaar, C., de Boer, A., Schalekamp, T., Souverein, P., A. Cate-Hoek, T., and Burden, A. M., Risk of myocardial infarction in patients with atrial fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants, Br J Clin Pharmacol, vol. 83, pp. 1835-1843, 2017.
N. Frey, Bodmer, M., Bircher, A., Ruegg, S., Jick, S. S., Meier, C. R., and Spoendlin, J., The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs, Epilepsia, vol. 58, pp. 2178-2185, 2017.
R. M. Joseph, Movahedi, M., Dixon, W. G., and Symmons, D. P., Risks of smoking and benefits of smoking cessation on hospitalisations for cardiovascular events and respiratory infection in patients with rheumatoid arthritis: a retrospective cohort study using the Clinical Practice Research Datalink, RMD Open, vol. 3, p. e000506, 2017.
M. Riera-Montes, Cattaert, T., and Verstraeten, T. V., Rotavirus vaccination may reduce acute gastroenteritis rates across all age groups in England, Value in Health, vol. 20, p. A780, 2017.
A. Ble, Hughes, P. M., Delgado, J., Masoli, J. A., Bowman, K., Zirk-Sadowski, J., Mota, R. E. Mujica, Henley, W. E., and Melzer, D., Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study, J Gerontol A Biol Sci Med Sci, vol. 72, pp. 243-250, 2017.
C. Becker, Jick, S. S., and Meier, C. R., Selective Serotonin Reuptake Inhibitors and Cataract Risk: A Case-Control Analysis, Ophthalmology, vol. 124, pp. 1635-1639, 2017.
R. A. Charlton, McGrogan, A., Snowball, J., Yates, L. M., Wood, A., Clayton-Smith, J., Smithson, W. H., Richardson, J. L., McHugh, N., Thomas, S. H., Baker, G. A., and Bromley, R., Sensitivity of the UK Clinical Practice Research Datalink to Detect Neurodevelopmental Effects of Medicine Exposure in Utero: Comparative Analysis of an Antiepileptic Drug-Exposed Cohort, Drug Saf, vol. 40, pp. 387-397, 2017.
J. C. Wilson, Sarsour, K., Collinson, N., Tuckwell, K., Musselman, D., Klearman, M., Napalkov, P., Jick, S. S., Stone, J. H., and Meier, C. R., Serious adverse effects associated with glucocorticoid therapy in patients with giant cell arteritis (GCA): A nested case-control analysis, Semin Arthritis Rheum, vol. 46, pp. 819-827, 2017.
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study, Bmj, vol. 356, p. j791, 2017.
K. T. Palmer, D'Angelo, S., Harris, E. C., Linaker, C., Sayer, A. A., Gale, C. R., Evandrou, M., Van Staa, T., Cooper, C., and Coggon, D., Sleep disturbance and the older worker: findings from the Health and Employment after Fifty study, Scand J Work Environ Health, vol. 43, pp. 136-145, 2017.
X. Xiao, Fischbach, S., Zhang, T., Chen, C., Sheng, Q., Zimmerman, R., Patnaik, S., Fusco, J., Ming, Y., Guo, P., Shiota, C., Prasadan, K., Gangopadhyay, N., Husain, S. Z., Dong, H., and Gittes, G. K., SMAD3/Stat3 Signaling Mediates beta-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes, Diabetes, vol. 66, pp. 2646-2658, 2017.
I. S. Mackenzie, Morant, S. V., Wei, L., Thompson, A. M., and MacDonald, T. M., Spironolactone use and risk of incident cancers: a retrospective, matched cohort study, Br J Clin Pharmacol, vol. 83, pp. 653-663, 2017.
S. H. Landis, Suruki, R., Hilton, E., Compton, C., and Galwey, N. W., Stability of Blood Eosinophil Count in Patients with COPD in the UK Clinical Practice Research Datalink, Copd, vol. 14, pp. 382-388, 2017.
[Page last reviewed 6 September 2019]