Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
R. Ravindrarajah, Dregan, A., Hazra, N. C., Hamada, S., Jackson, S. H. D., and Gulliford, M. C., Declining blood pressure and intensification of blood pressure management among people over 80 years: cohort study using electronic health records, J Hypertens, vol. 35, pp. 1276-1282, 2017.
J. D. Chalmers, Tebboth, A., Gayle, A., Ternouth, A., and Ramscar, N., Determinants of initial inhaled corticosteroid use in patients with GOLD A/B COPD: a retrospective study of UK general practice, NPJ Prim Care Respir Med, vol. 27, p. 43, 2017.
K. K. Poppe, Doughty, R. N., Wells, S., Gentles, D., Hemingway, H., Jackson, R., and Kerr, A. J., Developing and validating a cardiovascular risk score for patients in the community with prior cardiovascular disease, Heart, vol. 103, pp. 891-892, 2017.
C. Seliger, Meier, C. R., Becker, C., Jick, S. S., Proescholdt, M., Bogdahn, U., Hau, P., and Leitzmann, M. F., Diabetes, use of metformin, and the risk of meningioma, PLoS One, vol. 12, p. e0181089, 2017.
E. G. Tyrrell, Orton, E., Sayal, K., Baker, R., and Kendrick, D., Differing patterns in intentional and unintentional poisonings among young people in England, 1998-2014: a population-based cohort study, J Public Health (Oxf), vol. 39, pp. e1-e9, 2017.
T. Holbrook, Tang, Y., Das, R., Shankar, R. R., Tunceli, K., Williams, J., Radican, L., Holden, S. E., Morgan, C. L., Piercy, J., and Currie, C. J., Direct medical costs of severe hypoglycaemic events in patients with type 2 diabetes in England: A retrospective database study, Int J Clin Pract, vol. 71, 2017.
I. M. Carey, Hosking, F. J., Harris, T., DeWilde, S., Beighton, C., Shah, S. M., and Cook, D. G., Do health checks for adults with intellectual disability reduce emergency hospital admissions? Evaluation of a natural experiment, J Epidemiol Community Health, vol. 71, pp. 52-58, 2017.
S. I. Vuik, Fontana, G., Mayer, E., and Darzi, A., Do hospitalisations for ambulatory care sensitive conditions reflect low access to primary care? An observational cohort study of primary care usage prior to hospitalisation, BMJ Open, vol. 7, p. e015704, 2017.
M. Morris, Woods, L. M., Bhaskaran, K., and Rachet, B., Do pre-diagnosis primary care consultation patterns explain deprivation-specific differences in net survival among women with breast cancer? An examination of individually-linked data from the UK West Midlands cancer registry, national screening programme, BMC Cancer, vol. 17, p. 155, 2017.
C. Alexakis, Saxena, S., Chhaya, V., Cecil, E., Curcin, V., and Pollok, R., Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study, Inflamm Bowel Dis, vol. 23, pp. 672-680, 2017.
S. Weir, Samnaliev, M., Kuo, T. - C., Choitir, C. N., Tierney, T. S., Taylor, R. S., Manca, A., Bruce, J., Cumming, D., and Eldabe, S., Does instrumented spinal surgery have an increased rate of persistent post-operative pain (PPP)?, The Spine Journal, vol. 17, p. S11, 2017.
N. Larivee, Suissa, S., Eberg, M., Joseph, L., Eisenberg, M. J., Abenhaim, H. A., and Filion, K. B., Drospirenone-containing combined oral contraceptives and the risk of arterial thrombosis: a population-based nested case-control study, Bjog, vol. 124, pp. 1672-1679, 2017.
N. Larivee, Suissa, S., Coulombe, J., Tagalakis, V., and Filion, K. B., Drospirenone-Containing Oral Contraceptive Pills and the Risk of Venous Thromboembolism: An Assessment of Risk in First-Time Users and Restarters, Drug Saf, vol. 40, pp. 583-596, 2017.
A. Thompson, Ashcroft, D. M., Owens, L., van Staa, T. P., and Pirmohamed, M., Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study, PLoS One, vol. 12, p. e0173272, 2017.
F. Rees, Doherty, M., Lanyon, P., Davenport, G., Riley, R. D., Zhang, W., and Grainge, M. J., Early Clinical Features in Systemic Lupus Erythematosus: Can They Be Used to Achieve Earlier Diagnosis? A Risk Prediction Model, Arthritis Care Res (Hoboken), vol. 69, pp. 833-841, 2017.
M. Franklin, Davis, S., Horspool, M., Kua, W. S., and Julious, S., Economic Evaluations Alongside Efficient Study Designs Using Large Observational Datasets: the PLEASANT Trial Case Study, Pharmacoeconomics, vol. 35, pp. 561-573, 2017.
L. E. Bayliss, Culliford, D., Monk, A. P., Glyn-Jones, S., Prieto-Alhambra, D., Judge, A., Cooper, C., Carr, A. J., Arden, N. K., Beard, D. J., and Price, A. J., The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study, Lancet, vol. 389, pp. 1424-1430, 2017.
P. Brassard, Wu, J. W., Ernst, P., Dell'Aniello, S., Smiechowski, B., and Suissa, S., The effect of statins on influenza-like illness morbidity and mortality, Pharmacoepidemiol Drug Saf, vol. 26, pp. 63-70, 2017.
M. Pufulete, Maishman, R., Dabner, L., Mohiuddin, S., Hollingworth, W., Rogers, C. A., Higgins, J., Dayer, M., Macleod, J., Purdy, S., McDonagh, T., Nightingale, A., Williams, R., and Reeves, B. C., Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model, Health Technol Assess, vol. 21, pp. 1-150, 2017.
G. M. J. Taylor, Taylor, A. E., Thomas, K. H., Jones, T., Martin, R. M., Munafo, M. R., Windmeijer, F., and Davies, N. M., The effectiveness of varenicline versus nicotine replacement therapy on long-term smoking cessation in primary care: a prospective cohort study of electronic medical records, Int J Epidemiol, vol. 46, pp. 1948-1957, 2017.
E. Moore, Newson, R., Joshi, M., Palmer, T., Rothnie, K. J., Singh, S., Majeed, A., Soljak, M., and Quint, J. K., Effects of Pulmonary Rehabilitation on Exacerbation Number and Severity in People With COPD: An Historical Cohort Study Using Electronic Health Records, Chest, vol. 152, pp. 1188-1202, 2017.
K. Rahimi, Mohseni, H., Otto, C. M., Conrad, N., Tran, J., Nazarzadeh, M., Woodward, M., Dwyer, T., and MacMahon, S., Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults, PLoS Med, vol. 14, p. e1002404, 2017.
A. Thompson, Wright, A. K., Ashcroft, D. M., van Staa, T. P., and Pirmohamed, M., Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink, PLoS One, vol. 12, p. e0174818, 2017.
A. T. Cohen, Katholing, A., Rietbrock, S., Bamber, L., and Martinez, C., Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study, Thromb Haemost, vol. 117, pp. 57-65, 2017.
C. Klop, van Staa, T. P., Cooper, C., Harvey, N. C., and de Vries, F., The epidemiology of mortality after fracture in England: variation by age, sex, time, geographic location, and ethnicity, Osteoporos Int, vol. 28, pp. 161-168, 2017.
N. Frey, Jossi, J., Bodmer, M., Bircher, A., Jick, S. S., Meier, C. R., and Spoendlin, J., The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the UK, J Invest Dermatol, vol. 137, pp. 1240-1247, 2017.
P. P. Toth, Danese, M., Villa, G., Qian, Y., Beaubrun, A., Lira, A., and Jansen, J. P., Estimated burden of cardiovascular disease and value-based price range for evolocumab in a high-risk, secondary-prevention population in the US payer context, J Med Econ, vol. 20, pp. 555-564, 2017.
T. Verstraeten, Cattaert, T., Harris, J., Lopman, B., Tam, C. C., and Ferreira, G., Estimating the Burden of Medically Attended Norovirus Gastroenteritis: Modeling Linked Primary Care and Hospitalization Datasets, J Infect Dis, vol. 216, pp. 957-965, 2017.
E. Chiquette, Oral, E. A., Garg, A., Araujo-Vilar, D., and Dhankhar, P., Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges, Diabetes Metab Syndr Obes, vol. 10, pp. 375-383, 2017.
M. Eberg, Platt, R. W., and Filion, K. B., The Estimation of Gestational Age at Birth in Database Studies, Epidemiology, vol. 28, pp. 854-862, 2017.
J. Langham and Langham, S., European real world data sources to characterise flares in patients with systemic lupus erythematosus: A review, Value in Health, vol. 20, p. A571, 2017.
J. Birks, Bankhead, C., Holt, T. A., Fuller, A., and Patnick, J., Evaluation of a prediction model for colorectal cancer: retrospective analysis of 2.5 million patient records, Cancer Med, vol. 6, pp. 2453-2460, 2017.
J. Wong, Donegan, K., Seabroke, S., and Bryan, P., Evaluation of compliance to the timing of childhood vaccinations following introduction of the meningococcal B vaccine in the UK, Drug Safety, vol. 40, pp. 1000-1, 2017.
K. J. Lum, Newcomb, C. W., Roy, J. A., Carbonari, D. M., Saine, M. E., Cardillo, S., Bhullar, H., Gallagher, A. M., and , Evaluation of methods to estimate missing days' supply within pharmacy data of the Clinical Practice Research Datalink (CPRD) and The Health Improvement Network (THIN), Eur J Clin Pharmacol, vol. 73, pp. 115-123, 2017.
S. S. Zghebi, Steinke, D. T., Carr, M. J., Rutter, M. K., Emsley, R. A., and Ashcroft, D. M., Examining trends in type 2 diabetes incidence, prevalence and mortality in the UK between 2004 and 2014, Diabetes Obes Metab, vol. 19, pp. 1537-1545, 2017.
A. I. Kurdi, Chen, L. C., and Elliott, R. A., Exploring factors associated with patients' adherence to antihypertensive drugs among people with primary hypertension in the United Kingdom, J Hypertens, vol. 35, pp. 1881-1890, 2017.
B. I. Nwaru, Simpson, C. R., Sheikh, A., and Kotz, D., External validation of a COPD prediction model using population-based primary care data: a nested case-control study, Sci Rep, vol. 7, p. 44702, 2017.
L. E. Clarson, Hider, S. L., Belcher, J., Roddy, E., and Mallen, C. D., Factors Influencing Allopurinol Initiation in Primary Care, Ann Fam Med, vol. 15, pp. 557-560, 2017.
M. L. Gentil, Cuggia, M., Fiquet, L., Hagenbourger, C., Le Berre, T., Banatre, A., Renault, E., Bouzille, G., and Chapron, A., Factors influencing the development of primary care data collection projects from electronic health records: a systematic review of the literature, BMC Med Inform Decis Mak, vol. 17, p. 139, 2017.
C. L. Wilson, Rhodes, K. M., and Payne, R. A., Financial incentives improve recognition but not treatment of cardiovascular risk factors in severe mental illness, PLoS One, vol. 12, p. e0179392, 2017.
K. T. Palmer, D'Angelo, S., Harris, E. C., Linaker, C., Gale, C. R., Evandrou, M., Syddall, H., Van Staa, T., Cooper, C., A. Sayer, A., Coggon, D., and Walker-Bone, K., Frailty, prefrailty and employment outcomes in Health and Employment After Fifty (HEAF) Study, Occup Environ Med, vol. 74, pp. 476-482, 2017.
R. Y. Suruki, Daugherty, J. B., Boudiaf, N., and Albers, F. C., The frequency of asthma exacerbations and healthcare utilization in patients with asthma from the UK and USA, BMC Pulm Med, vol. 17, p. 74, 2017.
D. Stolz, Kostikas, K., Loefroth, E., Fogel, R., Clemens, A., Gutzwiller, F. S., Conti, V., and Cao, H., Gender differences in COPD exacerbations: Analysis from the CPRD database, Thorax, vol. 72, p. A186, 2017.
T. Verstraeten, Cattaert, T., and Ferreira, G., Gender inequality in acute gastro-enteritis rates in England., Value in Health, vol. 20, p. A781, 2017.
A. Shah, Prieto-Alhambra, D., Hawley, S., Delmestri, A., Lippett, J., Cooper, C., Judge, A., and Javaid, M. K., Geographic variation in secondary fracture prevention after a hip fracture during 1999-2013: a UK study, Osteoporos Int, vol. 28, pp. 169-178, 2017.
L. Li, Neogi, T., and Jick, S., Giant cell arteritis and vascular disease-risk factors and outcomes: a cohort study using UK Clinical Practice Research Datalink, Rheumatology (Oxford), vol. 56, pp. 753-762, 2017.
A. A. Sultan, Mallen, C., Hayward, R., Muller, S., Whittle, R., Hotston, M., and Roddy, E., Gout and subsequent erectile dysfunction: a population-based cohort study from England, Arthritis Res Ther, vol. 19, p. 123, 2017.
M. M. Crane, Webb, D. J., Watson, E., Cunliffe, T., and English, J., Hand eczema and steroid-refractory chronic hand eczema in general practice: prevalence and initial treatment, Br J Dermatol, vol. 176, pp. 955-964, 2017.
S. Borghs, Thieffry, S., Noack-Rink, M., Dedeken, P., Hong, L. S., Byram, L., Logan, J., Chan, J., and Kiri, V., Health care cost associated with the use of enzyme-inducing and non-enzyme-active antiepileptic drugs in the UK: a long-term retrospective matched cohort study, BMC Neurol, vol. 17, p. 59, 2017.
S. M. Collin, Bakken, I. J., Nazareth, I., Crawley, E., and White, P. D., Health care resource use by patients before and after a diagnosis of chronic fatigue syndrome (CFS/ME): a clinical practice research datalink study, BMC Fam Pract, vol. 18, p. 60, 2017.
[Page last reviewed 13 May 2019]