Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
02/10/2015	Evaluation of the clinical and economic outcomes associated with Bydureon versus basal insulin in people with type 2 diabetes
28/09/2015	Secondary prevention of acute coronary syndrome: comparative effectiveness of recommended vs. less intensive drug combination using Clinical Practice Research Datalink (CPRD). The SCARFACE-CPRD study.
23/09/2015	Evidence for and implications of channeling in the use of nonprescription acetaminophen and ibuprofen in an electronic medical records database
22/09/2015	The risk of fragility fracture in inflammatory arthritis: evidence for the effective and equitable targeting of prevention
18/09/2015	Study to investigate the drug treatment for sialorrhoea in children over the past 10 years.
15/09/2015	Assessing channelling bias and effectiveness in newly marketed glucose-lowering medications - a retrospective cohort study
15/09/2015	Can Continuity Of Primary Care Decrease Unscheduled Secondary Care Use?
14/09/2015	The incidence of Guillain-Barre Syndrome in the United Kingdom from April 2005 to March 2015.
11/09/2015	Healthcare resource utilisation and economic impact among kidney transplant patients during the last year before graft failure in the UK: a retrospective observational study
11/09/2015	Healthcare resource utilisation and economic impact among liver transplant patients during the last year before graft failure in the UK: a retrospective observational study
04/09/2015	Coronary Artery Disease in the Ageing Population of Adults with Congenital Heart Disease
04/09/2015	Time to treatment intensification and associated outcomes among patients with Type 2 diabetes mellitus in the UK
01/09/2015	Medical resource use and costs associated with diabetes complications in the population of diabetes patients receiving insulin therapy in the United Kingdom
28/08/2015	Demographic and clinical characteristics of T2DM patients treated with DPP-4 and SGLT2 inhibitors in the absence of a current clinical guideline - A CPRD Study
28/08/2015	Characteristics of newly diagnosed adults with Type 1 diabetes in the UK and their evolution over the first 5 years
28/08/2015	Cluster Headache Patient Prevalence and Prescribed Treatments in the UK Clinical Practice Research Datalink
18/08/2015	Risk of fragility fracture across inflammatory conditions: a UK population study
18/08/2015	Estimating the prevalence of myasthenia gravis and neuromyelitis optica through the Clinical Practice Research Datalink
17/08/2015	Alcohol misuse and injury outcomes in adolescents aged 10-24 using linked UK health data
17/08/2015	Resource use associated with Idiopathic Pulmonary Fibrosis