Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
14/01/2016	Burden of Multiple Myeloma (MM) in England: regional equity based on Real world data from CPRD HES, and Cancer Registry linked data.
12/01/2016	The risk of Clostridium Difficile Colitis and of pneumonia in persons with pernicious anaemia.
12/01/2016	Maternal Depression and Antidepressant Use During Pregnancy and Risk of Childhood Autism Spectrum Disorders (ASD) in Offspring: Population-based Cohort and Bidirectional Case-Crossover Sibling Study
04/01/2016	Domperidone and risk of primary liver cancer in the UK Clinical Practice Research Datalink
31/12/2015	Association between Diabetes Mellitus and Incident Meniere's Disease
31/12/2015	Validation of the recording of asthma diagnosis in adult patients in the Clinical Practice Research Datalink
30/12/2015	Quality and completeness of recording of social factors related to vaccine uptake in linked electronic health records
29/12/2015	Prescribing of antidepressants and adverse outcomes in patients with chronic kidney disease
23/12/2015	Incidence and Prevalence of the Parkinson's Disease in the United Kingdom during 1987-2014
23/12/2015	Novel Prediction Models for the One-Year Competing Risks of Death, Stroke, Intracranial Hemorrhage, and Extracranial Hemorrhage in Adults with Incident Non-Valvular Atrial Fibrillation
22/12/2015	Psychological stress and risk of herpes zoster
21/12/2015	Comparison of the risk of acute outcomes between patients with type 2 diabetes exposed to dapagliflozin and those exposed to other antidiabetic treatments
21/12/2015	Comparison of the risk of cancer outcomes between patients with type 2 diabetes exposed to dapagliflozin and those exposed to other antidiabetic treatments
18/12/2015	Descriptive study of patients with haemophilia in the CPRD.
14/12/2015	Trends and factors associated with therapy decisions in newly diagnosed COPD patients in GOLD groups A and B. A non-interventional study using the Clinical Practice Research Datalink (CPRD) database
08/12/2015	Cost Effectiveness of Different Patterns of Monitoring of Cardiovascular Medications in General Practices
08/12/2015	Patterns of prescribing in end of life care using CPRD data.
08/12/2015	An observational evaluation of prescribing of fixed-dose combination inhaled corticosteroid / long-acting beta2-agonist (ICS/LABA): fluticasone propionate / formoterol (FP/FOR) and adverse events in routine primary care at 18-months post launch
08/12/2015	Congenital malformations and maternal use of anti-hypertensive medication in the UK
07/12/2015	Bile duct and gallbladder diseases associated with the use of incretin-based drugs in patients with type 2 diabetes