Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/06/2023	A population-based assessment of drug-drug interactions with direct oral anticoagulants and the risk of major bleeding among patients with non-valvular atrial fibrillation
16/06/2023	Sex-specific differences in cardiovascular risk factors, risk factor management, treatment compliance and major cardiovascular outcomes in the peripheral arterial disease population
16/06/2023	The association between comorbid mental health conditions and risk of exacerbations and mortality among patients with chronic obstructive pulmonary disease
14/06/2023	DynAIRx (Dynamic Artificial Intelligence for Prescriptions): AIs (Artificial Intelligence) for dynamic prescribing optimisation and care integration in multimorbidity
13/06/2023	Risk factors, development of complications, and mortality in individuals with type 1 and type 2 diabetes
13/06/2023	Use of leukotriene receptor antagonists (LTRAs) among patients with asthma in the UK primary care: a drug utilisation study
13/06/2023	Real-world insights into the early treatment effects of dapagliflozin among patients with chronic kidney disease in UK clinical setting: an observational study
13/06/2023	Association between menopause and prognosis in dilated cardiomyopathy
13/06/2023	Risk of elevated plasma triglyceride levels on macrovascular and microvascular disease outcomes
12/06/2023	Using big data to investigate fetal and child outcomes following exposure to antiseizure medication in pregnancy
09/06/2023	Risk of cardiovascular events according to treatments patterns in patients with autoimmune disorders
07/06/2023	Defining an evidence base for the use of Advice and Guidance Referrals (BADGER)
07/06/2023	Community benzodiazepine and z-drug hypnotic prescribing after critical illness and the risk of emergency hospital readmission and death: a retrospective cohort study using the United Kingdom Clinical Practice Research Datalink (CPRD)
07/06/2023	External validation of longitudinal predictive models of health-related outcomes in patients older than 65 years of age
05/06/2023	Prevalence and Incidence of Duchenne Muscular Dystrophy in England
05/06/2023	PREdictors for DiabetIC Ketoacidosis at Diagnosis of Type 1 Diabetes (The PREDICT project)
05/06/2023	Longitudinal Assessment of Ethnicity Completeness and Distributions in CPRD Aurum
05/06/2023	Mental health outcomes in people with diabetes by health behaviours and body mass index
05/06/2023	Therapeutic inertia and its association with healthcare resource utilisation, complications, and costs in individuals with uncontrolled type 2 diabetes: a UK population-based retrospective analysis
05/06/2023	TNEPIX: Trigeminal Neuralgia epidemiology and informatics for characterising disease occurrence, patient journeys, healthcare impact and early diagnostic indications as an evidence package for establishment of UK specialist care centres