Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/03/2023	Glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter 2 inhibitors and the prevention of liver complications of non-alcoholic fatty liver disease among patients with type 2 diabetes
06/03/2023	Demographic groups and prodromal symptoms in rheumatoid arthritis (RA) in primary care: An analysis to support health equity in big-data clinical prediction models.
06/03/2023	Associations of clusters of adults with multimorbidity with clinical outcomes and healthcare utilisation
02/03/2023	Arterial and Venous Thromboembolism in patients with Hereditary Angioedema (AVeTHA) study
02/03/2023	Impact of the COVID-19 pandemic on mental health diagnoses and prescriptions in the UK
02/03/2023	Changes in prevalence and incidence of breast, colorectal, lung and prostate cancer, and treatment side effects, before and after the COVID-19 pandemic
28/02/2023	Characterising similarities and differences in Type 2 Diabetes, Overweight&Obese, and Non-Alcoholic SteatoHepatitis (NASH) patients and their risk of adverse clinical events: an observational cohort study in the United Kingdom
28/02/2023	EXAcerbations of Chronic Obstructive Pulmonary Disease (COPD) and their OutcomeS on CardioVascular diseases (EXACOS-CV) study: an observational cohort study in the UK
28/02/2023	The impact of COVID-19 vaccination on the long-term effects of COVID among adults in England diagnosed with COVID prior to Omicron dominance
23/02/2023	Estimating the Effects of Daylight Saving Time Clock Changes on Cardiovascular Outcomes, Depressive Symptoms and Road Traffic Injuries in England
23/02/2023	PREDICTion of GastroIntestinal malignancy in patients with IRON Deficiency (PREDICT-GI-IRON): a feasibility study
21/02/2023	Trends in need-adjusted general practice consultation rates in England, 1995 - 2022
21/02/2023	How would the refinement of urgent cancer referral criteria, by the inclusion of a broader set of variables available in primary care health records, affect numbers of patients eligible for referral and their outcomes?
20/02/2023	Epidemiology and health utilisation of patients treated with naldemedine; an observational retrospective cohort study
17/02/2023	Childbirth Acquired Perineal Trauma (Chapter) Study: Incidence of childbirth related perineal trauma (CRPT) and outcomes of women who experience CRPT
17/02/2023	Data availability for developing the EAMIT (East Anglian Malnutrition Identification Tool) Tool for earlier identification of malnutrition in the community: a feasibility study
17/02/2023	Pragmatic Randomised 104 Week Multicentre Trial to Evaluate the Comparative Effectiveness of dapagliflozin and Standard of Care in Type 2 Diabetes. The DECIDE Study.
17/02/2023	Identifying prescriptions in electronic health care (EHR) studies: methods for development of standardised, reproducible drug codelists for patients with Chronic Obstructive Pulmonary Disease (COPD)
17/02/2023	Familial Hypercholesterolaemia (FH) in the UK: Disparities in FH diagnosis and Intersectional Determinants of Health
17/02/2023	Second trimester loss: Estimating rates and understanding inequalities in loss - a retrospective cohort study in the CPRD database