Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
23/02/2023	Estimating the Effects of Daylight Saving Time Clock Changes on Cardiovascular Outcomes, Depressive Symptoms and Road Traffic Injuries in England
23/02/2023	PREDICTion of GastroIntestinal malignancy in patients with IRON Deficiency (PREDICT-GI-IRON): a feasibility study
21/02/2023	Trends in need-adjusted general practice consultation rates in England, 1995 - 2022
21/02/2023	How would the refinement of urgent cancer referral criteria, by the inclusion of a broader set of variables available in primary care health records, affect numbers of patients eligible for referral and their outcomes?
20/02/2023	Epidemiology and health utilisation of patients treated with naldemedine; an observational retrospective cohort study
17/02/2023	Second trimester loss: Estimating rates and understanding inequalities in loss - a retrospective cohort study in the CPRD database
17/02/2023	Identifying prescriptions in electronic health care (EHR) studies: methods for development of standardised, reproducible drug codelists for patients with Chronic Obstructive Pulmonary Disease (COPD)
17/02/2023	Pragmatic Randomised 104 Week Multicentre Trial to Evaluate the Comparative Effectiveness of dapagliflozin and Standard of Care in Type 2 Diabetes. The DECIDE Study.
17/02/2023	Childbirth Acquired Perineal Trauma (Chapter) Study: Incidence of childbirth related perineal trauma (CRPT) and outcomes of women who experience CRPT
17/02/2023	Familial Hypercholesterolaemia (FH) in the UK: Disparities in FH diagnosis and Intersectional Determinants of Health
17/02/2023	Data availability for developing the EAMIT (East Anglian Malnutrition Identification Tool) Tool for earlier identification of malnutrition in the community: a feasibility study
17/02/2023	Maternal and offspring outcomes associated with pre-pregnancy maternal multiple long-term conditions
15/02/2023	Optimisation of care journeys for patients with diabetes and co-morbidiies in NHS England: identifying risks and opportunities for better outcomes
15/02/2023	The effect of diabetes medications on chronic obstructive pulmonary disease exacerbations: a population-cohort study
15/02/2023	Eligibility of patients with chronic obstructive pulmonary disease for triple therapy studies in routine clinical practice
13/02/2023	Lipid-lowering therapy in young people with familial hypercholesterolaemia: A cohort study using primary and secondary care data to measure reductions in cholesterol, adherence, and safety
13/02/2023	Factor Xa inhibitors associated major bleeding characterisation, burden and management in UK clinical setting: an observational study
13/02/2023	Comparative effectiveness of sodium-glucose co-transporter-2 inhibitors (SGLT-2i), glucagon-like peptide-1 receptor agonists (GLP-1RA), or dipeptidyl peptidase-4 inhibitors (DPP-4i) vs. sulfonylureas (SU) in patients with type 2 diabetes
13/02/2023	Characterization of the epidemiology, treatment patterns and burden of Pulmonary Hypertension Group 1 and 3 in the UK: a real-word evidence study.
09/02/2023	To assess the comparative effectiveness and real-world utilization of novel oral anticoagulants in patients with nonvalvular atrial fibrillation in the United Kingdom