Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
31/03/2021	Effectiveness of Indapamide Sustained Released on top of Perindopril on blood pressure change: a methodological study to validate effect of anti-hypertensive drugs in Clinical Research Practice Datalink
31/03/2021	The impact of systemic corticosteroids on major adverse cardiovascular events, solid-tumours and mortality in adults: a retrospective cohort study.
30/03/2021	Incidence and prevalence of Antiphospholipid Syndrome in United Kingdom.
25/03/2021	Retrospective database study to describe healthcare resource utilization in patients on antimuscarinics with overactive bladder in England
24/03/2021	The use of locum doctors in the UK National Health System (NHS): understanding and improving the safety and quality of care
24/03/2021	The Role of Tuberculosis Disease on Non-Communicable Disease Risk: Comparative Analysis of Large Healthcare Databases
24/03/2021	The effectiveness of opicapone treatment compared to entacapone in Parkinson's disease using electronic primary healthcare records and linked secondary care data
24/03/2021	The impact of systemic corticosteroids on diabetes mellitus and osteoporosis in adults: a retrospective cohort study
24/03/2021	Epidemiology and treatment of Myasthenia Gravis (MG): A retrospective study in Clinical Practice Research Datalink (CPRD) and Hospital Episodes Statistics (HES)
24/03/2021	Trends in use of Glucose-lowering Medications in Patients with Type 2 Diabetes and Chronic Kidney Disease, 2000-2020
24/03/2021	Econometric analysis of the distribution of primary and secondary costs and activity for patients with non-communicable diseases
24/03/2021	Investigate the determinants and trends of heart failure and other major cardiovascular events in diabetes patients and their subsequent prognosis within the UK population
23/03/2021	Evaluating the risk of incident cardiovascular disease and cardiovascular drug prescribing patterns in patients with liver disease
23/03/2021	The Impact of COVID-19 lockdown on the lives of People with Obesity (PwO): A UK primary care based study
22/03/2021	Outcomes of maternal epilepsy and antiepileptic medications during pregnancy (PREPArE)
18/03/2021	The impact of area level deprivation and geographical variation on survival and resource use in patients with colorectal, gastro-oesophageal, lung or ovarian cancer in England.
18/03/2021	A Case Control and Cohort Design Study, using Multi-state Models, Analysis of Treatment Patterns in Chronic Obstructive Pulmonary Disease and Asthma.
18/03/2021	Natural history of disease and real-world health outcomes of patients with Fabry disease in the UK
18/03/2021	Burden of Disease and Treatment Patterns for Patients with Hip and Knee Osteoarthritis in the United Kingdom
17/03/2021	Can we use routinely collected primary care medical records to assess and explain variations in major lower extremity amputation rates across the England?