Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
20/05/2021	Real-World Effectiveness of Denosumab in Prevention of Fracture among Postmenopausal Osteoporotic Women with FREEDOM Baseline Characteristics
18/05/2021	Morbidity, mortality, resource use, and financial cost of pruritus in chronic kidney disease patients in the UK general population: a retrospective matched cohort study
18/05/2021	Comparison of modelling methods for risk prediction of cardiovascular outcomes in patients with hypertension
13/05/2021	Maternal prescriptive drug use: the risks and benefits to mothers and neonates
13/05/2021	Effectiveness of triple therapy versus dual therapy in patients with chronic obstructive pulmonary disease who have had one severe or two or more moderate exacerbations within one year
13/05/2021	Antidementia drugs use in patients with Alzheimer's disease
12/05/2021	Investigating the influence of ethnicity in Atrial Fibrillation, focusing on the epidemiology, risk factors and outcomes; a population based study.
12/05/2021	Health resource utilisation and cost burden of individuals with Amyotrophic Lateral Sclerosis (ALS) in England
11/05/2021	Patient portal registration and healthcare utilisation outcomes of patients in the NHS General Practice.
11/05/2021	The effect of diabetes mellitus on perioperative outcomes following colorectal resectional surgery
11/05/2021	Use of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors for the Prevention of Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes
11/05/2021	Association between haemoglobin levels and clinical outcomes and healthcare resource use in patients with sickle cell disease in England
07/05/2021	Incidence and prevalence of mental illness in pregnancy and the first five years after giving birth: a retrospective cohort study using electronic primary care data
07/05/2021	An assessment of clinical staff workload and predictors of clinical staff workload, in UK primary care settings
07/05/2021	Use and effectiveness of non-pharmaceutical interventions for mild to moderate depression
06/05/2021	The risk of acute infection in patients with newly diagnosed depression: a cohort study
06/05/2021	Impact of underlying diseases, diagnostic processes and treatment on heart failure disease trajectory using international data
05/05/2021	Evaluating ethnic differences in blood markers of cancer in primary care
04/05/2021	The Prescribing of Analgesia and Predictors of Long-Term Analgesia Prescriptions in Patients with Inflammatory Arthritis: An Observational Study using the Clinical Practice Research Datalink.
30/04/2021	Completeness and representativeness of small area socioeconomic data linked with the UK Clinical Practice Research Datalink (CPRD)