Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
19/01/2023	The prevalence of single or co-existing type 2 inflammatory diseases in the United Kingdom, and associated primary and secondary healthcare resource use and cost in England using the Clinical Practice Research Datalink and Hospital Episode Statistics
19/01/2023	Assessing prevalence and treatments or interventions for smoking and overweight and obesity in women during pre-conception and the associations with pregnancy complications and neonatal outcomes in primary care
19/01/2023	The risk of acute infection in new users of antidepressants: an observational cohort study
19/01/2023	Trends in health seeking behaviour and treatment decisions, and risk factors for recurrent preschool wheeze in children from different ethnic and socioeconomic backgrounds
17/01/2023	The association between pharmacological treatments for dementia and the risk of developing age related macular degeneration, cataract, glaucoma, and deafness or hearing loss
17/01/2023	Understanding treatment patterns, care pathways and the economic burden of migraine among adults in England: A retrospective cohort study.
16/01/2023	Pain-Related Healthcare Utilisation in Patients with Inflammatory Arthritis and Comorbid Depression and Anxiety: A Descriptive Observational Study.
09/01/2023	Estimation of population-level incidence rates of designated medical events for pharmacovigilance
05/01/2023	Deprescribing in elderly patients with cardiometabolic conditions during end of life care: a United Kingdom Clinical Practice Research Datalink Retrospective Cohort Study
05/01/2023	Defining fibrotic multi-morbidity in the UK population using electronic healthcare records
15/12/2022	Treatment delays in Tuberculosis: a multi-method study including an epidemiological and validation study, self-controlled case series and case-control studies
15/12/2022	Drug utilisation studies for medicines of regulatory interest
14/12/2022	Short term clinically important deterioration as an indicator of medium and long-term Chronic Obstructive Pulmonary Disease progression: An external validation of Canadian population based longitudinal Cohort findings in the UK primary care population
08/12/2022	A retrospective observational study on treatment pathway, healthcare resource use, and mortality of patients with drug resistant epilepsy in England using the Clinical Practice Research Database linked to Hospital Episode Statistics
08/12/2022	FINEGUST: FINErenone druG Utilization Study and assessment of Temporal changes following availability of different treatment options in patients with chronic kidney disease and type 2 diabetes
07/12/2022	Evaluating diagnostic window presence and length for 'hard-to-suspect' conditions using linked longitudinal health records
06/12/2022	Characteristics of patients with COPD initiating single inhaled triple therapy (Trixeo; Budesonide, Glycopyrronium and Formoterol) in the United Kingdom: a population-based cohort study using Clinical Practice Research Datalink data
05/12/2022	Sociodemographic inequalities along the cancer patient pathway - interplay between individual and healthcare system characteristics
01/12/2022	Drug Utilisation Study on antibiotics included in the World Health Organisation's watch list for evaluation and monitoring of use.
01/12/2022	Pregnancy protection and pregnancies in women of reproductive age on ACE-Inhibitors (ACEi), Angiotensin Receptor Blockers (ARB), statins or anti-diabetic medications: an observational study in primary care.