Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page

Date of Approval Sort ascending Title
28/11/2022 Post-authorisation safety study to assess the risk of urinary tract malignancies in relation to empagliflozin exposure in patients with type 2 diabetes: a multi-database European study
25/11/2022 UK Clinical Practice Research Datalink sudden cardiac death incidence, disparities and determinants of risk
24/11/2022 Effect of conventional disease-modifying antirheumatic drugs on microvascular complications among patients with type 2 diabetes and rheumatoid arthritis
23/11/2022 Statins as adjuncts to first-line therapy for tuberculosis disease
18/11/2022 The menopause transition and mental health disorders: a population-based cohort study
18/11/2022 Long-term Impact of Stroke or Transient Ischemic Attack, Acute Coronary Syndrome, and Atrial Fibrillation
14/11/2022 A risk score for pancreatic cancer diagnosis using machine learning techniques applied to linked routine data: full case-control study and economic evaluation
11/11/2022 Drug utilisation of valproate-containing medicinal products in women of childbearing potential
11/11/2022 Herpes zoster vaccine and the risk of stroke: a population-based cohort study using linked data from the Clinical Practice Research Datalink
11/11/2022 Developing an impactibility model for Chronic Obstructive Pulmonary Disease
11/11/2022 Comparative effectiveness and safety of edoxaban compared with apixaban in elderly patients with nonvalvular atrial fibrillation
11/11/2022 The epidemiology and impact of growth hormone deficiency in adults: A population-based study in the UK
09/11/2022 UK-wide variability in consultation, management and healthcare utilisation for back pain in older adults: a descriptive study
09/11/2022 Trends of GP reported falls after fracture and exploration of imminent fall risk after fracture among patients in the UK using CPRD GOLD (1990-2015)
08/11/2022 FIRST-1: a retrospective descriptive analysis of renal and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes
08/11/2022 Primary care encounters for foot and ankle problems in children and young people: a population-based cohort study
08/11/2022 A retrospective cohort study investigating the associations between adherence and persistence to basal insulin therapy and healthcare resource use for people with type 2 diabetes in England
08/11/2022 Development of a patient-level simulation model to estimate lifetime cardiovascular health outcomes in patients with chronic kidney disease
08/11/2022 Consultation prevalence and incidence of musculoskeletal pain and its management in children and adolescents in primary care
03/11/2022 Investigating the effect of combination therapy with glucagon like peptide-1 receptor agonist and sodium-glucose co-transporter-2 inhibition on cardiovascular and renal disease outcomes in persons with type 2 diabetes