Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
03/11/2022	Investigating the effect of combination therapy with glucagon like peptide-1 receptor agonist and sodium-glucose co-transporter-2 inhibition on cardiovascular and renal disease outcomes in persons with type 2 diabetes
03/11/2022	Combination treatment of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors and the risk of cardiovascular and serious renal outcomes
03/11/2022	The comparative safety and effectiveness of heterologous versus homologous prime-booster COVID-19 vaccination regiments: a cohort study
02/11/2022	Quantifying the healthcare costs attributable to gestational diabetes mellitus
02/11/2022	Estimation of population level incidence and prevalence of rare diseases in Europe: a multinational collaboration as part of the Data Analysis and Real World Interrogation Network (DARWIN EU)
01/11/2022	Estimating the incidence and prevalence of 308 clinical conditions in the UK
01/11/2022	The Psychosis Metabolic Risk Calculator (PsyMetRiC) - Validation, Recalibration and Model Revision Study
01/11/2022	Exploring the feasibility and effect of adjusting for confounding using markers of health-seeking behaviour and healthcare access in observational cohort studies of influenza and COVID-19 vaccine effectiveness.
31/10/2022	A retrospective, non-interventional study of treatment pathways, treatment outcomes, burden of illness and unmet needs of patients with hidradenitis suppurativa (HS) in England
31/10/2022	Identifying implementation gaps in fracture preventive care in patients receiving oral corticosteroids: Population-based cohort study in older adults in the UK
27/10/2022	Burden of human immunodeficiency virus (HIV), patterns of antiretroviral prescriptions and multimorbidity clusters
27/10/2022	The epidemiology of injuries, poisonings and external causes of morbidity and mortality in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
27/10/2022	Examining the risk of long term opioid use and associated adverse events in patients undergoing major surgery in England
27/10/2022	Mortality and healthcare resource utilisation in patients with severe uncontrolled asthma in the UK: a retrospective cohort study
25/10/2022	Recording of unpaid carers in GP practice records in England: An exploratory study
24/10/2022	A Retrospective Observational Study Describing Healthcare Resource Utilisation and Greenhouse Gas Emissions Associated with Severe Asthma Care in the UK using the Clinical Practice Research Datalink (CPRD)
21/10/2022	Developing treatment selection models for diabetes
20/10/2022	The epidemiology of conditions occurring during pregnancy, childbirth and the puerperium in the United Kingdom and the healthcare care cost and resource use associated with managing these conditions
20/10/2022	Maternal anaemia during pregnancy and the risk of congenital heart disease in offspring: a case-control study using linked electronic health records in England
18/10/2022	Acute illness as a driver of long-term disease and health inequality across socioeconomic and ethnic groups