Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
02/12/2020	Temporal trends in arthroscopic subacromial decompression during and after conduct of a large UK multi-centre trial
01/12/2020	Epidemiology, Natural History and Burden of Disease in Patients with Alpha-1 Antitrypsin Deficiency in the UK: A Real-World Retrospective Cohort Study
01/12/2020	Effectiveness and cost-effectiveness of alcohol use screening tests and treatments for alcohol-use disorders
01/12/2020	The risk factors for hospital admission amongst people with parkinsonism in the UK.
01/12/2020	A Retrospective Observational Cohort Study Describing Epidemiology, Patient Characteristics, Treatment Patterns and The Potential Burden Of Inhaled Short Acting Beta-2 Agonist (SABA) Over-prescription And Inhaled Corticosteroids (ICS) Under-prescription A
01/12/2020	Understanding the association between diabetes and severe COVID-19 infection.
01/12/2020	Assessment of the burden of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) in England
01/12/2020	Producing epidemiologic estimates by cancer type in England: A cohort study using linked primary care to secondary data sources
25/11/2020	Who benefits and who suffers harm from discontinuation of renin-angiotensin-aldosterone system inhibitors? A regression discontinuity study
24/11/2020	Feasibility analysis of a European infrastructure for COVID-19 vaccine monitoring: Background rates of Adverse Events of Special Interest
24/11/2020	Determining the incidence, prevalence and impact of Psoriatic Arthritis and Fibromyalgia or Chronic Widespread Pain in UK Primary Care: A Health Intelligence Analysis.
23/11/2020	Effectiveness of primary care COPD management in the UK: a regression discontinuity design
20/11/2020	Polycystic ovarian syndrome and metformin use in pregnant woman. Possible reduction of fetal loss. A cohort study in the Clinical Practice Research Datalink.
19/11/2020	Re-evaluating the clinical and cost effectiveness of implantable cardioverter defibrillator (ICD) or cardiac resynchronisation therapy with defibrillation (CRT-D) for heart failure using real world data from the Clinical Practice Research Datalink.
18/11/2020	Effects of oral anticoagulation in patients with atrial fibrillation and close-to-threshold stroke risk score (CHA2DS2-VASc) or chronic kidney disease: A regression discontinuity analysis
18/11/2020	Health Outcomes Arising from Human-Animal Interactions Including Zoonotic Disease and Antimicrobial Resistance
16/11/2020	Use and effectiveness of physical activity and dietary based lifestyle interventions for patients with hypercholesterolaemia
16/11/2020	The role of clinical and care factors in the delay of heart failure diagnosis and subsequent prognosis: a cohort study using the Clinical Practice Research Datalink (CPRD)
13/11/2020	An assessment of the cardiovascular health of autistic individuals
11/11/2020	Use and effectiveness of physical activity and dietary based lifestyle interventions for obesity