Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
25/09/2020	Global burden of hip fractures – trends in incidence, post-fracture treatment, and mortality; a multi-country, observational study
25/09/2020	Safety of non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating urate-lowering therapy for gout: an observational study in UK primary care using the Clinical Practice Research Datalink
25/09/2020	Non-steroidal anti-inflammatory drugs and the risk of myocardial infarction: a nested case-control study in the UK Clinical Practice Research Datalink GOLD
25/09/2020	Epidemiological investigations of the role of viral infections, viral treatments, vaccination prevention and the risk of dementia
22/09/2020	Using large-scale routine data to monitor and improve ethnic inequalities in cancer and cardiovascular disease
22/09/2020	Estimating the effects of early intervention services for first-episode psychosis and model fidelity on hospitalisations: a quasi-experimental study
21/09/2020	Incidence, prevalence, resource use and clinical outcomes of heart failure in England: a linked descriptive analysis of primary and secondary care (PULSE)
18/09/2020	Quality and completeness of rheumatoid arthritis (RA) diagnosis in CPRD GOLD and CPRD AURUM
17/09/2020	A comparison of cancer incidence and prevalence in CPRD GOLD and CPRD Aurum primary care databases
17/09/2020	Understanding the prevalence and characteristics of frequent attenders in general practice using the Clinical Practice Research Datalink
16/09/2020	Drug-drug interactions and the risk of sulfonylurea-induced hypoglycaemia
16/09/2020	Examining primary care interactions, monitoring, prescribing and outcomes pre, during, and post Covid-19 in people with diabetes
16/09/2020	Association Between Opioid Prescriptions and Postoperative Anastomotic Leak After Restorative Proctectomy for Rectal Cancer
14/09/2020	Anxiety and depression amongst secondary school children: variation across academic years and the relationship with high-stakes examinations
10/09/2020	Incretin-based drugs and the risk of intestinal obstruction among patients with type 2 diabetes
10/09/2020	Establishing unmet need for Chronic Kidney Disease services to inform a virtual clinic evaluation: a feasibility study
09/09/2020	The impact of the quality and accessibility of primary health care on avoidable mortality: a longitudinal comparison of people with intellectual disabilities and the general population
08/09/2020	ALETHEIA: An observational study on treatment patterns and clinical outcomes of patients experiencing a myocardial infarction in clinical practice
08/09/2020	Assessment of Prevalence and Risk Factors for Psychiatric Morbidity after Restorative Proctectomy for Rectal Cancer – A Population-Based Cohort Study
08/09/2020	Fertility rates and pregnancy outcomes in women with psoriasis and psoriatic arthritis: a population-based cohort study