Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
11/11/2020	Estimating Incidence and Prevalence of Atherothrombotic Events in Coronary Artery Disease, Peripheral Artery Disease and Ischaemic Stoke Patients on Standard of Care Antiplatelet Treatment: a England Cohort Study
11/11/2020	A combined cross-sectional and cohort study to describe and quantify polypharmacy among people prescribed antidepressants, including quantifying frequent drug combinations and adverse events
10/11/2020	Acute and long-term health outcomes for people who survived COVID-19: matched cohort analyses using UK primary and secondary care data
03/11/2020	To investigate the prevalence, incidence and mortality for Interstitial Lung Disease (ILD) in the UK for the study period 2009 to 2019
03/11/2020	Development of an algorithm to identify Hypereosinophilic Syndrome using the Clinical Practice Research Datalink linked with hospital data
02/11/2020	A population-based longitudinal study in England of suicide risk indicators: behavioural, clinical and biosocial
02/11/2020	Cardiometabolic disease prediction using general practice consultation pattern: Use of Machine Learning (ML)
30/10/2020	Exploring clinical pathways of knee joint replacement using large-scale electronic healthcare record data
28/10/2020	Proposal to develop an algorithm to link mothers to their children in CPRD Aurum
28/10/2020	Characteristics and treatment pathways among patients with chronic obstructive pulmonary disease receiving single device dual inhaler therapy in the UK in a real-world setting
28/10/2020	Comparative adherence and persistence of single & multiple inhaler triple therapies among patients with Chronic Obstructive Pulmonary Disease in the United Kingdom in a real-world primary care setting
26/10/2020	European non-interventional post-authorization safety study related adherence to the risk minimization measures for romosozumab by the EU-ADR Alliance
26/10/2020	Application of machine learning algorithms on electronic health records to examine patterns of disease clustering and trajectories
23/10/2020	Chronic kidney disease burden and characterisation of patients by renal function testing, treatments and comorbidities - an observational study
21/10/2020	An investigation of the reliability and granularity of the recording of interstitial lung diseases in primary and secondary care datasets
20/10/2020	MuSculoskeletal paiN durIng the COVID-19 PandEmic: an observational study of UK national primary care electronic health records (the SNIPE Study)
20/10/2020	Development of a prediction model in Pompe disease, Fabry disease, and Gaucher disease based on UK electronic primary healthcare records and linked secondary care data.
19/10/2020	Near real time vaccine safety monitoring for COVID-19 vaccines
15/10/2020	The impact of painful musculoskeletal conditions on outcomes of cardiovascular disease
15/10/2020	Second-line combined treatment with metformin and DPP-4 inhibitors in type 2 diabetes and risk of major cardiovascular events, cardiovascular and all-cause mortality: a prevalent new-user cohort study