Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
14/10/2020	The prescribing trends and health risks of prescribed analgesic medication in the UK: an observational study based on the UK Clinical Practice Research Datalink
14/10/2020	Burden and consequences of the use of COPD-related systemic corticosteroids
14/10/2020	Which patient groups benefit from statins? A regression discontinuity study
12/10/2020	Characterisation of nasal polyp patients with and without surgery in England (CPRD-HES)
12/10/2020	An observational cohort study of intermittent oral corticosteroid use and its association with adverse outcomes and healthcare resource use and costs in asthma using the Optimum Patient Care Research and Clinical Practice Research Datalink databases.
08/10/2020	Real world disease burden and treatment patterns among patients diagnosed with gastroparesis in England
08/10/2020	Descriptive efficiency and safety of a combination of ramipril and bisoprolol in patients with primary hypertension: A Database Study
07/10/2020	Prevalence and socio-economic distribution of patients with atherosclerotic cardiovascular disease (ASCVD) and hypercholesterolemia, ASCVD-risk equivalent patients with hypercholesterolemia, and familial hypercholesterolemia
06/10/2020	Atrial Fibrillation, cognitive impairment, dementia, and the impact of antithrombotic therapy: A population-based cohort study using the Clinical Practice Research Datalink.
06/10/2020	Pharmacological risk factors for community-acquired pneumonia in asthma: population-based study in England
06/10/2020	Which patient groups at risk for type 2 diabetes benefit from lifestyle interventions: a regression discontinuity design
05/10/2020	Metformin, lifestyle advice, and risk of Type 2 Diabetes Mellitus. A comparative effectiveness cohort study in older prediabetic patients, in the Clinical Practice Research Practice AURUM
02/10/2020	Outcome of fractures in people with intellectual disabilities
30/09/2020	Quality and completeness of breast cancer recording in CPRD Aurum compared to CPRD GOLD
30/09/2020	Musculoskeletal adverse outcomes after treatment with aromatase inhibitors for breast cancer
28/09/2020	Metformin and the risk of multiple sclerosis: A population based cohort study
25/09/2020	Safety of non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating urate-lowering therapy for gout: an observational study in UK primary care using the Clinical Practice Research Datalink
25/09/2020	Epidemiological investigations of the role of viral infections, viral treatments, vaccination prevention and the risk of dementia
25/09/2020	Global burden of hip fractures – trends in incidence, post-fracture treatment, and mortality; a multi-country, observational study
25/09/2020	Epidemiology of anticoagulants prescribing in non-valvular atrial fibrillation patients in England: a cohort study exploring disease incidence and anticoagulants prescribing trends, comparing clinical outcomes, and risk of recurrent bleeding events