Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
23/05/2018	Acute exacerbation of idiopathic pulmonary fibrosis in the UK: incidence, mortality and disease severity
22/05/2018	Seasonal Influenza Vaccine Effectiveness and Safety in Asthma
22/05/2018	Evaluation of the Burden and Management of Musculoskeletal Diseases
22/05/2018	The Association of oral bisphosphonate use with mortality risk following a major osteoporotic fracture in the UK
22/05/2018	Long-term relative effectiveness of monotherapy antihypertensive drugs in patients newly diagnosed with hypertension. A cohort study in the UK Clinical Practice Research Datalink (CPRD)
21/05/2018	Trends in acute exacerbation and related hospitalization among COPD patients in the UK (2005-2013)
21/05/2018	Treatment patterns and burden of agitation in patients with Alzheimer's disease in the UK
21/05/2018	Blood eosinophilia, withdrawal of inhaled corticosteroids and risk of COPD exacerbations and mortality
17/05/2018	High-need patients with chronic conditions: primary and secondary care utilisation and costs, by social and demographic characteristics in high income countries.
17/05/2018	An investigation into the effect of quality of antenatal care on the risk of stillbirths in the UK
15/05/2018	The association between inflammatory markers measured in blood and incident seizures
15/05/2018	Real World Evidence Study to Support Project Obesity: Determine co-diseases scenarios among Overweight and Obese patients. Assessment of metabolic profiles and economic burden of these different scenarios
15/05/2018	Paracetamol versus Ibuprofen and the risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding and Renal Impairment
15/05/2018	A quasi-experimental study to assess the effectiveness of an educational intervention for improving identification and management of familial hypercholesterolemia in general practice
15/05/2018	Is seasonal influenza vaccine effectiveness reduced in people receiving repeat vaccinations? A retrospective cohort study using the Clinical Practice Research Database
15/05/2018	The association between bariatric surgery and incident hip or knee arthroplasty: A matched cohort study in obese patients
15/05/2018	Causes of death in patients with gout and impact of urate lowering therapy: a population based cohort study
15/05/2018	The risk of incident osteoarthritis of the hand in women with new use of estrogen replacement therapy or raloxifene: a cohort study with a nested case-control analysis
15/05/2018	Are patients with high normal platelet counts at increased risk of cancer? The NORMA study
15/05/2018	Developing indicators for failure or delays in recognising clinical deterioration and escalation of care across primary care