Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
15/06/2018	Comparing the effectiveness of COPD treatments in the UK
14/06/2018	Descriptive Analysis of Pro-Arrhythmic Risk of Drug Therapies
12/06/2018	Alzheimer’s disease subtype discovery in electronic health records using cluster analysis
11/06/2018	Deriving parameters of long-term cardiovascular outcomes and health care utilisation for a cost-effectiveness model in patients with familial hypercholesterolaemia diagnosed in primary care
11/06/2018	Investigating the potential side effects of the human papillomavirus vaccine: a novel regression discontinuity analysis using the UK Clinical Practice Research Datalink
11/06/2018	Use of primary care and hospital services in children and young people aged less than 25 years in England; descriptive study
08/06/2018	Replication of the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) in a cohort study using electronic primary care data
08/06/2018	The utilisation of linaclotide in patients with Irritable Bowel Syndrome predominantly with constipation (IBS-C) in the United Kingdom: a retrospective observational study using the Clinical Practice Research Datalink
08/06/2018	Prescribing of high dose oral ibuprofen (1800mg/day or more) in UK primary care
08/06/2018	Retrospective cohort study to understand the natural history and burden of disease of Huntington’s disease in the United Kingdom
08/06/2018	The cumulative incidence of seizures during 21 days after new use of oral antibiotics - a cohort study
01/06/2018	Rate and risk of cardiovascular events and all-cause mortality in individuals with type 2 diabetes, with and without microalbuminuria - a cohort study in the CPRD database
01/06/2018	Using CPRD to describe the current management of heart failure in England and model risk trajectories to improve shared decision-making
01/06/2018	Determinants associated with treatment modification in the first year of treatment in patients with type 2 diabetes mellitus in the United Kingdom, before and after implementation of the new guideline: a retrospective cohort study
01/06/2018	Evaluating the NHS Diabetes Prevention Programme (NHS DPP): Assessing whether the NHS DPP is more effective than usual care in reducing conversion of nondiabetic hyperglycaemia to diabetes, eventually reducing diabetes prevalence in England
30/05/2018	Persistence and adherence to controlled release formulations of sodium valproate for the treatment of epilepsy and their clinical and resource use implications.
30/05/2018	Effect of stepping down (reducing) a stable asthma patient’s maintenance medication on the risk of an acute asthma attack
30/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT) Study 12 : “Quantification of the risk of liver injury associated with flucloxacillin: a UK population-based cohort study”
30/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 11 - Replication of "Co-administration of statins with cytochrome P450 3A4 inhibitors in a UK primary care population"
30/05/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 6 - Replication of "Glucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK CPRD"