Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
28/11/2018	Burden of disease in patients with Chronic Obstructive Pulmonary Disease (COPD)
28/11/2018	An impact evaluation of the Joint Royal College of General Practitioners (RCGP)-Clinical Practice Research Datalink (CPRD) quality improvement initiative
26/11/2018	Incidence and management of sudden sensorineural hearing loss in primary and secondary care
26/11/2018	The impact of knee replacement on mortality in the presence of chronic disease
22/11/2018	Trends in the prescribing of opioids for non-malignant pain in UK primary care: a descriptive study
21/11/2018	The prevalence of co-prescribing of tramadol and antidepressants during 1998-2017, and associated risk of all-cause mortality and emergency hospital admissions
21/11/2018	Missed opportunities for limb salvage in patients undergoing major amputation - a retrospective cohort study of the clinical practice research datalink
20/11/2018	Feasibility study to assess identification of the care home residency population from CPRD
19/11/2018	Risk of hospitalised Influenza, England, 2000-2017
19/11/2018	Progression of preschool wheeze to school age asthma: English population study 2000 to 2017
19/11/2018	Estimating the incidence of acute complications of herpes zoster: a matched cohort study using UK healthcare data
19/11/2018	Disease Burden and Health Care Utilisation and Costs among Patients with Nonalcoholic Steatohepatitis (NASH) and Nonalcoholic Fatty Liver Disease (NAFLD)
19/11/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 18-Replication of "Risk of Myocardial infarction in Patients with Atrial Fibrillation using vitamin K antagonists, aspirin or direct acting oral anticoagulants"
19/11/2018	DPP-4 inhibitor dose selection according to Summaries of Product Characteristics: A contemporary experience from the UK General Practice
16/11/2018	An external validation of the SMART vascular event risk prediction model in a secondary prevention UK routine care cohort
14/11/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT) Study 19: Replication of "Long-term use of dipeptidyl peptidase-4 inhibitors and risk of fracture: A retrospective population-based cohort study."
13/11/2018	Proton pump inhibitor use and the risk of myocardial infarction: a nested case-control study in the UK Clinical Practice Research Datalink.
08/11/2018	Do beta adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A Prospective cohort study using the Clinical Practice Research Datalink
07/11/2018	Risk of adverse mental health outcomes in women with a history of breast cancer in the United Kingdom: a population-based matched cohort study
06/11/2018	Changes in COPD inhaler prescriptions in the UK, 2000 to 2016