Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
12/07/2018	Drug utilisation among primary care patients with knee osteoarthritis (KOA): a population-based study using CPRD
12/07/2018	Nested case-control study of the impact of PSA screening on prostate cancer mortality in England
10/07/2018	The extent of medication complexity in general practice
10/07/2018	The combine effect of renin angiotensin aldosterone system blockage and Sodium-glucose co-transporter-2 receptor inhibition on renal outcomes in type 2 diabetes
09/07/2018	Understanding the role of serum electrolytes in the presentation of specific fatal and non-fatal cardiovascular disease syndromes: a research proposal using linked CPRD-HES-ONS data
09/07/2018	Risk Stratification and multimorbidity in Chronic Obstructive Pulmonary Disease (COPD)
09/07/2018	Impact of ethnicity on the development of kidney disease in the UK, a retrospective database study
09/07/2018	Impact of atrial fibrillation (AF) awareness campaigns on the rate of AF related consultations in UK primary care: an interrupted time series analyses
04/07/2018	A cohort study investigating the association of flucloxacillin and liver injury within people previously exposed to the drug
04/07/2018	Prognostic relevance of severe hypoglycaemia and factors associated with poor outcomes in subjects experiencing severe hypoglycaemia
28/06/2018	Is herpes zoster associated with risk of incident dementia? A cohort study using the Clinical Practice Research Datalink.
28/06/2018	Risk factors for overtreatment and undertreatment of glucose-control in patients with diabetes mellitus and association of overtreatment with mortality
22/06/2018	Prevalence, incidence, and natural history of gastroparesis in the United Kingdom: real world evidence from the Clinical Practice Research Datalink
22/06/2018	Withdrawing inhaled corticosteroid (ICS) treatment in people with COPD: a real world study
20/06/2018	The impact of not speaking English as a first language on diabetes control and outcomes in primary care
20/06/2018	Health Impact Assessment to predict the impact of an increase in tobacco pricing on the burden of COPD in Italy, Sweden and the United Kingdom
18/06/2018	Investigating healthcare utilisation for heart failure patients with or without cardiac implantable electronic devices in England: retrospective cohort study.
15/06/2018	Health benefits of sustained weight loss in people with overweight or obesity
15/06/2018	What influence does obesity have on healthcare utilisation cost for patients with and without cardiovascular diseases?
15/06/2018	Use of inhaled corticosteroids and risk of pneumonia in asthma