Approved studies using CPRD Data

Access to CPRD data, including UK Primary Care Data, and linked data such as Hospital Episode Statistics, is subject to protocol approval via CPRD’s Research Data Governance (RDG) Process. Independent scientific and patient advice is provided by Expert Review Committees (ERCs) and the Central Advisory Committee (CAC). 

A summary of all approved protocols, including a lay and technical summary of the proposed research, is published three months after RDG approval. COVID-19 research protocols are being fast-tracked and all approved summaries are published within 72 hours to ensure transparency and to help avoid unnecessary duplication. 

Protocols below are listed in order of date of approval. Please click on the study title for more details. 

Peer-reviewed publications from research using CPRD data will be listed on our bibliography page. 

Date of Approval	Title
06/11/2018	An analysis of linked healthcare datasets to examine the relationship between secondary prevention and long-term outcomes in patients with aortic disease in England
06/11/2018	A retrospective examination of glaucoma patients in the CPRD database with contraindications for anti-glaucoma beta-blocker therapy
06/11/2018	Living with Ulcerative Colitis Study in England: A non-interventional, retrospective study in England to evaluate healthcare resource utilization and the direct healthcare cost of post-operative care in patients with ulcerative colitis
06/11/2018	Changes in lung function over time in a primary care COPD cohort and their relationship with patient demographic, clinical and health-care utilization characteristics
06/11/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT): Study 16 - "Use of tamoxifen and aromatase inhibitors in a large population-based cohort of women with breast cancer"
06/11/2018	Impact of recurrent hospitalization events on mortality in patients with Heart Failure: a retrospective analysis of a UK database
05/11/2018	Maternal and perinatal characteristics associated with Respiratory Tract Infection (RTI) healthcare utilisation and death in a birth cohort using the CPRD database and other linked databases
05/11/2018	Evaluation of probable treatment indications for the prescription of oral glycopyrronium in the United Kingdom - both licensed and off-label
31/10/2018	Patient and practice level factors associated with influenza vaccine uptake among adults in England: a 7-year multi-level retrospective cohort study
31/10/2018	Determine the association between RSV/bronchiolitis episodes in young children and subsequent childhood episodes of wheeze and asthma (up to age 10 years), using a birth cohort
31/10/2018	Respiratory Syncytial Virus (RSV) healthcare burden in England during the period 2007-2017
31/10/2018	The burden of respiratory disease in people living with HIV infection in the UK Clinical Practice Research Datalink
30/10/2018	Assessing the Chronicity and Burden of Hyperkalaemia in Patients with Cardiorenal Comorbidities
30/10/2018	Reproducible Evidence: Practices to Enhance and Achieve Transparency (REPEAT):Study 15 - Replication of "Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events."
29/10/2018	SELECT: Selection of Eligible People for Lung Cancer Screening using Electronic Primary Care DaTa: Development of new risk prediction models
29/10/2018	Annual healthcare resource utilisation attributable to meningococcal disease (MD) in the UK during the period 2008-2017 – retrospective database analysis
29/10/2018	Burden of meningococcal disease (MD) in the UK during the period 2008-2017 - retrospective database analysis
25/10/2018	Burden of Hypereosinophilic syndrome (HES) in the UK
25/10/2018	Development and validation of a prognostic model for use in primary care which estimates the probability of individuals with non-diabetic hyperglycaemia developing type 2 diabetes
25/10/2018	Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study