Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
N. C. Hazra, Rudisill, C., and Gulliford, M. C., Determinants of health care costs in the senior elderly: age, comorbidity, impairment, or proximity to death?, Eur J Health Econ, vol. 19, pp. 831-842, 2018.
D. Yu, Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., Mallen, C. D., Tan, V., Ukachukwu, V., Prieto-Alhambra, D., Walker, C., and Peat, G., Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink, Ann Rheum Dis, 2018.
D. Abrahami, Douros, A., Yin, H., Yu, O. H. Y., Renoux, C., Bitton, A., and Azoulay, L., Dipeptidyl peptidase-4 inhibitors and incidence of inflammatory bowel disease among patients with type 2 diabetes: population based cohort study, Bmj, vol. 360, p. k872, 2018.
J. Ride, Kasteridis, P., Gutacker, N., Kronenberg, C., Doran, T., Mason, A., Rice, N., Gravelle, H., Goddard, M., Kendrick, T., Siddiqi, N., Gilbody, S., Dare, C. R., Aylott, L., Williams, R., and Jacobs, R., Do care plans and annual reviews of physical health influence unplanned hospital utilisation for people with serious mental illness? Analysis of linked longitudinal primary and secondary healthcare records in England, BMJ Open, vol. 8, p. e023135, 2018.
A. Leite, Thomas, S. L., and Andrews, N. J., Do delays in data availability limit the implementation of near real-time vaccine safety surveillance using the Clinical Practice Research Datalink?, Pharmacoepidemiol Drug Saf, vol. 27, pp. 25-29, 2018.
A. Harshfield, Abel, G. A., Barclay, S., and Payne, R. A., Do GPs accurately record date of death? A UK observational analysis, BMJ Support Palliat Care, 2018.
P. Dhiman, Andersen, S., Vestergaard, P., Masud, T., and Qureshi, N., Does bone mineral density improve the predictive accuracy of fracture risk assessment? A prospective cohort study in Northern Denmark, BMJ Open, vol. 8, p. e018898, 2018.
A. Mehrabadi, Reynier, P., Platt, R. W., and Filion, K. B., Domperidone for insufficient lactation in England 2002-2015: A drug utilization study with interrupted time series analysis, Pharmacoepidemiol Drug Saf, vol. 27, pp. 1316-1324, 2018.
J. E. Thistle, Petrick, J. L., Yang, B., Bradley, M. C., Graubard, B. I., and McGlynn, K. A., Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink, Cancer Epidemiol, vol. 55, pp. 170-175, 2018.
Y. Tao and Fu, H., Doubly robust estimation of the weighted average treatment effect for a target population, Stat Med, 2018.
D. J. Humes, Abdul-Sultan, A., Walker, A. J., Ludvigsson, J. F., and West, J., Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study, Hernia, vol. 22, pp. 447-453, 2018.
C. Koshiaris, Van den Bruel, A., Oke, J. L., Nicholson, B. D., Shephard, E., Braddick, M., and Hamilton, W., Early detection of multiple myeloma in primary care using blood tests: a case-control study in primary care, Br J Gen Pract, vol. 68, pp. e586-e593, 2018.
H. A. Abenhaim, Tulandi, T., Wilchesky, M., Platt, R., Spence, A. R., Czuzoj-Shulman, N., and Suissa, S., Effect of Cesarean Delivery on Long-term Risk of Small Bowel Obstruction, Obstet Gynecol, vol. 131, pp. 354-359, 2018.
N. M. Davies, Taylor, G. M. J., Taylor, A. E., Jones, T., Martin, R. M., Munafo, M. R., Windmeijer, F., and Thomas, K. H., The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records, Addiction, vol. 113, pp. 1105-1116, 2018.
K. J. Roberts, Bannister, C. A., and Schrem, H., Enzyme replacement improves survival among patients with pancreatic cancer: Results of a population based study, Pancreatology, 2018.
A. Cassell, Edwards, D., Harshfield, A., Rhodes, K., Brimicombe, J., Payne, R., and Griffin, S., The epidemiology of multimorbidity in primary care: a retrospective cohort study, Br J Gen Pract, vol. 68, pp. e245-e251, 2018.
M. Liang, Ye, T., and Fu, H., Estimating individualized optimal combination therapies through outcome weighted deep learning algorithms, Stat Med, vol. 37, pp. 3869-3886, 2018.
L. R. Vaz, Jones, M. J., Szatkowski, L., Tata, L. J., Petrou, S., and Coleman, T., Estimating the health-care costs of children born to pregnant smokers in England: cohort study using primary and secondary health-care data, Addiction, vol. 113, pp. 1305-1316, 2018.
H. Caspard, Steffey, A., Mallory, R. M., and Ambrose, C. S., Evaluation of the safety of live attenuated influenza vaccine (LAIV) in children and adolescents with asthma and high-risk conditions: a population-based prospective cohort study conducted in England with the Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e023118, 2018.
C. I. Bloom, Nissen, F., Douglas, I. J., Smeeth, L., Cullinan, P., and Quint, J. K., Exacerbation risk and characterisation of the UK's asthma population from infants to old age, Thorax, vol. 73, pp. 313-320, 2018.
J. M. Gamble, Chibrikov, E., Midodzi, W. K., Twells, L. K., and Majumdar, S. R., Examining the risk of depression or self-harm associated with incretin-based therapies used to manage hyperglycaemia in patients with type 2 diabetes: a cohort study using the UK Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e023830, 2018.
K. Donegan, Owen, R., Bird, H., Burch, B., Smith, A., and Tregunno, P., Exploring the Potential Routine Use of Electronic Healthcare Record Data to Strengthen Early Signal Assessment in UK Medicines Regulation: Proof-of-Concept Study, Drug Saf, vol. 41, pp. 899-910, 2018.
R. M. Joseph, van Staa, T. P., Lunt, M., Abrahamowicz, M., and Dixon, W. G., Exposure measurement error when assessing current glucocorticoid use using UK primary care electronic prescription data, Pharmacoepidemiol Drug Saf, 2018.
J. Jackson, Lewis, N. V., Feder, G. S., Whiting, P., Jones, T., Macleod, J., and Redaniel, M. T., Exposure to domestic violence and abuse and consultations for emergency contraception: nested case-control study in a UK primary care dataset, Br J Gen Pract, 2018.
D. R. Morales, Flynn, R., Zhang, J., Trucco, E., Quint, J. K., and Zutis, K., External validation of ADO, DOSE, COTE and CODEX at predicting death in primary care patients with COPD using standard and machine learning approaches, Respir Med, vol. 138, pp. 150-155, 2018.
T. K. Mukhtar, Bankhead, C., Stevens, S., Perera, R., Holt, T. A., Salisbury, C., and Hobbs, F. R., Factors associated with consultation rates in general practice in England, 2013-2014: a cross-sectional study, Br J Gen Pract, vol. 68, pp. e370-e377, 2018.
C. I. Alatorre, Hoogwerf, B. J., Deeg, M. A., Nelson, D. R., Hunter, T. M., Ng, W. T., and Rekhter, M. D., Factors associated with stroke, myocardial infarction, ischemic heart disease, unstable angina, or mortality in patients from real world clinical practice with newly-diagnosed type 2 diabetes and early glycemic control, Curr Med Res Opin, vol. 34, pp. 337-343, 2018.
O. Moussa, Arhi, C., Ziprin, P., Darzi, A., Khan, O., and Purkayastha, S., Fate of the metabolically healthy obese-is this term a misnomer? A study from the Clinical Practice Research Datalink, Int J Obes (Lond), 2018.
M. Iwagami, Tomlinson, L. A., Mansfield, K. E., Douglas, I. J., Smeeth, L., and Nitsch, D., Gastrointestinal bleeding risk of selective serotonin reuptake inhibitors by level of kidney function: A population-based cohort study, Br J Clin Pharmacol, vol. 84, pp. 2142-2151, 2018.
R. de Jong, Peeters, P., Burden, A. M., De Bruin, M. L., Haak, H. R., Masclee, A. A. M., de Vries, F., and Janssen-Heijnen, M. L. G., Gastrointestinal cancer incidence in type 2 diabetes mellitus; results from a large population-based cohort study in the UK, Cancer Epidemiol, vol. 54, pp. 104-111, 2018.
J. L. Hong, M. Funk, J., LoCasale, R., Dempster, S. E., Cole, S. R., Webster-Clark, M., Edwards, J. K., and Sturmer, T., Generalizing Randomized Clinical Trial Results: Implementation and Challenges Related to Missing Data in the Target Population, Am J Epidemiol, vol. 187, pp. 817-827, 2018.
A. Douros, Filion, K. B., Yin, H., Yu, O. H., Etminan, M., Udell, J. A., and Azoulay, L., Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Incident Diabetic Retinopathy, Diabetes Care, vol. 41, pp. 2330-2338, 2018.
C. L. Morgan, Qiao, Q., Grandy, S., Johnsson, K., Jenkins-Jones, S., Holden, S., and Currie, C. J., Glucose Control and Weight Change Associated with Treatment with Exenatide Compared with Basal Insulin: A Retrospective Study, Diabetes Ther, vol. 9, pp. 269-283, 2018.
C. Rebordosa, Plana, E., Aguado, J., Thomas, S., Garcia-Gil, E., Perez-Gutthann, S., and Castellsague, J., GOLD assessment of COPD severity in the Clinical Practice Research Datalink (CPRD), Pharmacoepidemiol Drug Saf, 2018.
M. Kerkhof, Tran, T. N., Soriano, J. B., Golam, S., Gibson, D., Hillyer, E. V., and Price, D. B., Healthcare resource use and costs of severe, uncontrolled eosinophilic asthma in the UK general population, Thorax, vol. 73, pp. 116-124, 2018.
H. Otete, Fleming, M. K., West, J., and Orton, E., Healthcare Utilisation, Morbidities and Alcohol Use Monitoring Prior to Alcoholic Psychosis Diagnosis, Alcohol Alcohol, 2018.
S. Vanni, Zattoni, M., Moda, F., Giaccone, G., Tagliavini, F., Haik, S., Deslys, J. P., Zanusso, G., Ironside, J. W., Carmona, M., Ferrer, I., Kovacs, G. G., and Legname, G., Hemoglobin mRNA Changes in the Frontal Cortex of Patients with Neurodegenerative Diseases, Front Neurosci, vol. 12, p. 8, 2018.
R. Kumar, Hepatitis B virus infection and diabetes mellitus: An adverse relationship A letter in response to Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK: A population-based cohort study using the UK Clinical Practice Researc, J Viral Hepat, vol. 25, p. 1401, 2018.
M. Ardissino, Moussa, O., Tang, A., Muttoni, E., Ziprin, P., and Purkayastha, S., Idiopathic intracranial hypertension in the British population with obesity, Acta Neurochir (Wien), 2018.
M. Hickman, Steer, C., Tilling, K., Lim, A. G., Marsden, J., Millar, T., Strang, J., Telfer, M., Vickerman, P., and Macleod, J., The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom, Addiction, vol. 113, pp. 1461-1476, 2018.
E. Martin-Merino, Calderon-Larranaga, A., Hawley, S., Poblador-Plou, B., Llorente-Garcia, A., Petersen, I., and Prieto-Alhambra, D., The impact of different strategies to handle missing data on both precision and bias in a drug safety study: a multidatabase multinational population-based cohort study, Clin Epidemiol, vol. 10, pp. 643-654, 2018.
C. J. Currie, Holden, S. E., Jenkins-Jones, S., Morgan, C. L., Voss, B., Rajpathak, S. N., Alemayehu, B., Peters, J. R., and Engel, S. S., Impact of differing glucose-lowering regimens on the pattern of association between glucose control and survival, Diabetes Obes Metab, vol. 20, pp. 821-830, 2018.
J. Daugherty, Lin, X., Baxter, R., Suruki, R., and Bradford, E., The impact of long-term systemic glucocorticoid use in severe asthma: A UK retrospective cohort analysis, J Asthma, vol. 55, pp. 651-658, 2018.
J. L. Atkins, Delgado, J., Pilling, L. C., Bowman, K., Masoli, J. A. H., Kuchel, G. A., Ferrucci, L., and Melzer, D., Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts, J Gerontol A Biol Sci Med Sci, 2018.
E. Cecil, Bottle, A., Ma, R., Hargreaves, D. S., Wolfe, I., ,, and Saxena, S., Impact of preventive primary care on children's unplanned hospital admissions: a population-based birth cohort study of UK children 2000-2013, BMC Med, vol. 16, p. 151, 2018.
K. C. Chang, Vamos, E. P., Palladino, R., Majeed, A., Lee, J. T., and Millett, C., Impact of the NHS Health Check on inequalities in cardiovascular disease risk: a difference-in-differences matching analysis, J Epidemiol Community Health, 2018.
C. L. Morgan, Inzucchi, S. E., Puelles, J., Jenkins-Jones, S., and Currie, C. J., Impact of treatment with pioglitazone on stroke outcomes: A real-world database analysis, Diabetes Obes Metab, vol. 20, pp. 2140-2147, 2018.
G. L. C. Ferreira, Marano, C., De Moerlooze, L., Guignard, A., Feng, Y., Y. Hahi, E., and Van Staa, T., Incidence and prevalence of hepatitis B in patients with diabetes mellitus in the UK: A population-based cohort study using the UK Clinical Practice Research Datalink, J Viral Hepat, vol. 25, pp. 571-580, 2018.
J. C. Wilson, Sarsour, K., Gale, S., Petho-Schramm, A., Jick, S. S., and Meier, C. R., Incidence and risk of glucocorticoid-associated adverse effects in patients with rheumatoid arthritis, Arthritis Care Res (Hoboken), 2018.
R. Y. van der Velde, Wyers, C. E., Geusens, P., van den Bergh, J. P. W., de Vries, F., Cooper, C., van de Staa, T. P., and Harvey, N. C., Incidence of subsequent fractures in the UK between 1990 and 2012 among individuals 50 years or older, Osteoporos Int, vol. 29, pp. 2469-2475, 2018.
[Page last reviewed 13 May 2019]