Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
H. Strongman, Kausar, I., and Maher, T. M., Incidence, Prevalence, and Survival of Patients with Idiopathic Pulmonary Fibrosis in the UK, Adv Ther, vol. 35, pp. 724-736, 2018.
J. G. Royle, Lanyon, P. C., Grainge, M. J., Abhishek, A., and Pearce, F. A., The incidence, prevalence, and survival of systemic sclerosis in the UK Clinical Practice Research Datalink, Clin Rheumatol, vol. 37, pp. 2103-2111, 2018.
R. J. Partington, Muller, S., Helliwell, T., Mallen, C. D., and A. Sultan, A., Incidence, prevalence and treatment burden of polymyalgia rheumatica in the UK over two decades: a population-based study, Ann Rheum Dis, vol. 77, pp. 1750-1756, 2018.
C. Conradt, Guo, D., Miclea, A., Nisslein, T., Ismail, C., Chatamra, K., and Andersohn, F., Increased Prevalence of Polyneuropathy in Parkinson's Disease Patients: An Observational Study, J Parkinsons Dis, vol. 8, pp. 141-144, 2018.
M. Simeonova, de Vries, F., Pouwels, S., Driessen, J. H. M., Leufkens, H. G. M., Cadarette, S. M., and Burden, A. M., Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK, Br J Clin Pharmacol, vol. 84, pp. 2551-2561, 2018.
E. Richardson, Bedson, J., Chen, Y., Lacey, R., and Dunn, K. M., Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink, Eur J Pain, vol. 22, pp. 1701-1708, 2018.
D. Abrahami, Douros, A., Yin, H., Yu, O. H., Faillie, J. L., Montastruc, F., Platt, R. W., Bouganim, N., and Azoulay, L., Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study, Bmj, vol. 363, p. k4880, 2018.
D. Abrahami, Yin, H., Yu, O. H. Y., Pollak, M. N., and Azoulay, L., Incretin-based Drugs and the Incidence of Colorectal Cancer in Patients with Type 2 Diabetes, Epidemiology, vol. 29, pp. 246-253, 2018.
A. Jain, van Hoek, A. J., Walker, J. L., Forbes, H. J., Langan, S. M., Root, A., Smeeth, L., and Thomas, S. L., Inequalities in zoster disease burden: a population-based cohort study to identify social determinants using linked data from the U.K. Clinical Practice Research Datalink, Br J Dermatol, vol. 178, pp. 1324-1330, 2018.
A. Matcho, Ryan, P., Fife, D., Gifkins, D., Knoll, C., and Friedman, A., Inferring pregnancy episodes and outcomes within a network of observational databases, PLoS One, vol. 13, p. e0192033, 2018.
S. R. Markar, Arhi, C., Leusink, A., Vidal-Diez, A., Karthikesalingam, A., Darzi, A., Lagergren, J., and Hanna, G. B., The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study, Ann Surg, vol. 268, pp. 861-867, 2018.
V. Prasad, West, J., Sayal, K., and Kendrick, D., Injury among children and young people with and without attention-deficit hyperactivity disorder in the community: The risk of fractures, thermal injuries, and poisonings, Child Care Health Dev, vol. 44, pp. 871-878, 2018.
D. E. Robinson, van Staa, T. P., Dennison, E. M., Cooper, C., and Dixon, W. G., The limitations of using simple definitions of glucocorticoid exposure to predict fracture risk: A cohort study, Bone, vol. 117, pp. 83-90, 2018.
E. Badrick, Renehan, I., and Renehan, A. G., Linkage of the UK Clinical Practice Research Datalink with the national cancer registry, Eur J Epidemiol, 2018.
M. Sabido, Thilo, H., and Guido, G., Long-term effectiveness of bisoprolol in patients with angina: A real-world evidence study, Pharmacol Res, vol. 139, pp. 106-112, 2018.
U. Koppe, Nitsch, D., Mansfield, K. E., Mathur, R., Bhaskaran, K., Batterham, R. L., Smeeth, L., and Douglas, I. J., Long-term effects of bariatric surgery on acute kidney injury: a propensity-matched cohort in the UK Clinical Practice Research Datalink, BMJ Open, vol. 8, p. e020371, 2018.
A. D. Mosholder, Lee, J. Y., Zhou, E. H., Kang, E. M., Ghosh, M., Izem, R., Major, J. M., and Graham, D. J., Long-Term Risk of Acute Myocardial Infarction, Stroke, and Death With Outpatient Use of Clarithromycin: A Retrospective Cohort Study, Am J Epidemiol, vol. 187, pp. 786-792, 2018.
A. Dregan, Ravindrarajah, R., Charlton, J., Ashworth, M., and Molokhia, M., Long-term trends in antithrombotic drug prescriptions among adults aged 80 years and over from primary care: a temporal trends analysis using electronic health records, Ann Epidemiol, vol. 28, pp. 440-446, 2018.
R. M. Joseph, Ray, D. W., Keevil, B., van Staa, T. P., and Dixon, W. G., Low salivary cortisol levels in patients with rheumatoid arthritis exposed to oral glucocorticoids: a cross-sectional study set within UK electronic health records, RMD Open, vol. 4, p. e000700, 2018.
K. W. Hagberg, Robijn, A. L., and Jick, S., Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring, Clin Epidemiol, vol. 10, pp. 1599-1612, 2018.
L. Scheepers, Burden, A. M., Arts, I. C. W., Spaetgens, B., Souverein, P., de Vries, F., and Boonen, A., Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD), Rheumatology (Oxford), vol. 57, pp. 1641-1650, 2018.
M. Cainzos-Achirica, Varas-Lorenzo, C., Pottegard, A., Asmar, J., Plana, E., Rasmussen, L., Bizouard, G., Forns, J., Hellfritzsch, M., Zint, K., Perez-Gutthann, S., and Pladevall-Vila, M., Methodological challenges when evaluating potential off-label prescribing of drugs using electronic health care databases: A case study of dabigatran etexilate in Europe, Pharmacoepidemiol Drug Saf, vol. 27, pp. 713-723, 2018.
S. A. J. Schmidt, Langan, S. M., Pedersen, H. S., Schonheyder, H. C., Thomas, S. L., Smeeth, L., Mansfield, K. E., Sorensen, H. T., Forbes, H. J., and Vestergaard, M., Mood Disorders and Risk of Herpes Zoster in 2 Population-Based Case-Control Studies in Denmark and the United Kingdom, Am J Epidemiol, vol. 187, pp. 1019-1028, 2018.
L. Li, Neogi, T., and Jick, S., Mortality in Patients With Giant Cell Arteritis: A Cohort Study in UK Primary Care, Arthritis Care Res (Hoboken), vol. 70, pp. 1251-1256, 2018.
O. M. Moussa, Erridge, S., Chidambaram, S., Ziprin, P., Darzi, A., and Purkayastha, S., Mortality of the Severely Obese: A Population Study, Ann Surg, 2018.
K. J. Rothnie, Connell, O., Mullerova, H., Smeeth, L., Pearce, N., Douglas, I., and Quint, J. K., Myocardial Infarction and Ischemic Stroke after Exacerbations of Chronic Obstructive Pulmonary Disease, Ann Am Thorac Soc, vol. 15, pp. 935-946, 2018.
K. J. Rothnie, Mullerova, H., Smeeth, L., and Quint, J. K., Natural History of Chronic Obstructive Pulmonary Disease Exacerbations in a General Practice-based Population with Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med, vol. 198, pp. 464-471, 2018.
E. L. Axson, Bloom, C. I., and Quint, J. K., Nontuberculous mycobacterial disease managed within UK primary care, 2006-2016, Eur J Clin Microbiol Infect Dis, vol. 37, pp. 1795-1803, 2018.
F. A. Pearce, Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., and Hubbard, R. B., Novel insights into the aetiology of granulomatosis with polyangiitis-a case-control study using the Clinical Practice Research Datalink, Rheumatology (Oxford), vol. 57, pp. 1002-1010, 2018.
E. Nortoft, Chubb, B., and Borglykke, A., Obesity and healthcare resource utilization: comparative results from the UK and the USA, Obes Sci Pract, vol. 4, pp. 41-45, 2018.
C. W. le Roux, Chubb, B., Nortoft, E., and Borglykke, A., Obesity and healthcare resource utilization: results from Clinical Practice Research Database (CPRD), Obes Sci Pract, vol. 4, pp. 409-416, 2018.
G. Glover, Williams, R., Tompkins, G., and Oyinlola, J., An observational study of the use of acute hospital care by people with intellectual disabilities in England, J Intellect Disabil Res, 2018.
S. A. Julious, Horspool, M. J., Davis, S., Franklin, M., Smithson, W. H., Norman, P., Simpson, R. M., Elphick, H., Bortolami, O., and Cooper, C., Open-label, cluster randomised controlled trial and economic evaluation of a brief letter from a GP on unscheduled medical contacts associated with the start of the school year: the PLEASANT trial, BMJ Open, vol. 8, p. e017367, 2018.
C. Garriga, Pazianas, M., Hawley, S., Delmestri, A., Prieto-Alhambra, D., Cooper, C., and Judge, A., Oral bisphosphonate use and age-related macular degeneration: retrospective cohort and nested case-control study, Ann N Y Acad Sci, vol. 1415, pp. 34-46, 2018.
K. Gruntz, Bloechliger, M., Becker, C., Jick, S. S., Fuhr, P., Meier, C. R., and Ruegg, S., Parkinson disease and the risk of epileptic seizures, Ann Neurol, vol. 83, pp. 363-374, 2018.
H. J. I. De Jong, Tervaert, J. W. Cohen, Lalmohamed, A., de Vries, F., Vandebriel, R. J., Van Loveren, H., Klungel, O. H., and van Staa, T. P., Pattern of risks of rheumatoid arthritis among patients using statins: A cohort study with the clinical practice research datalink, PLoS One, vol. 13, p. e0193297, 2018.
J. Tran, Norton, R., Conrad, N., Rahimian, F., Canoy, D., Nazarzadeh, M., and Rahimi, K., Patterns and temporal trends of comorbidity among adult patients with incident cardiovascular disease in the UK between 2000 and 2014: A population-based cohort study, PLoS Med, vol. 15, p. e1002513, 2018.
A. V. Margulis, Linder, M., Arana, A., Pottegard, A., Berglind, I. A., Bui, C. L., Kristiansen, N. S., Bahmanyar, S., McQuay, L. J., Atsma, W. J., Appenteng, K., D'Silva, M., Perez-Gutthann, S., and Hallas, J., Patterns of use of antimuscarinic drugs to treat overactive bladder in Denmark, Sweden, and the United Kingdom, PLoS One, vol. 13, p. e0204456, 2018.
L. McDonald, Schultze, A., Carroll, R., and Ramagopalan, S. V., Performing studies using the UK Clinical Practice Research Datalink: to link or not to link?, Eur J Epidemiol, vol. 33, pp. 601-605, 2018.
F. A. Achana, Fleming, K. M., Tata, L. J., Sultan, A. A., and Petrou, S., Peripartum hysterectomy: an economic analysis of direct healthcare costs using routinely collected data, Bjog, vol. 125, pp. 874-883, 2018.
M. Sabido, Hohenberger, T., and Grassi, G., Pharmacological intervention in hypertension using beta-blockers: Real-world evidence for long-term effectiveness, Pharmacol Res, vol. 130, pp. 191-197, 2018.
H. Strongman, Christopher, S., Majak, M., Williams, R., Bahmanyar, S., Linder, M., Heintjes, E. M., Bennett, D., Korhonen, P., and Hoti, F., Pioglitazone and cause-specific risk of mortality in patients with type 2 diabetes: extended analysis from a European multidatabase cohort study, BMJ Open Diabetes Res Care, vol. 6, p. e000481, 2018.
E. G. Tyrrell, Kendrick, D., Sayal, K., and Orton, E., Poisoning substances taken by young people: a population-based cohort study, Br J Gen Pract, vol. 68, pp. e703-e710, 2018.
A. Cherskov, Pohl, A., Allison, C., Zhang, H., Payne, R. A., and Baron-Cohen, S., Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory, Transl Psychiatry, vol. 8, p. 136, 2018.
T. R. Berni, Morgan, C. L., Berni, E. R., and Rees, D. A., Polycystic Ovary Syndrome Is Associated With Adverse Mental Health and Neurodevelopmental Outcomes, J Clin Endocrinol Metab, vol. 103, pp. 2116-2125, 2018.
S. Jenkins-Jones, Parviainen, L., Porter, J., Withe, M., Whitaker, M. J., Holden, S. E., Morgan, C. L., Currie, C. J., and Ross, R. J. M., Poor compliance and increased mortality, depression and healthcare costs in patients with congenital adrenal hyperplasia, Eur J Endocrinol, vol. 178, pp. 309-320, 2018.
J. R. Ingram, Jenkins-Jones, S., Knipe, D. W., Morgan, C. L. I., Cannings-John, R., and Piguet, V., Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa, Br J Dermatol, vol. 178, pp. 917-924, 2018.
J. Busby, Mills, K., Zhang, S. D., Liberante, F. G., and Cardwell, C. R., Postdiagnostic Calcium Channel Blocker Use and Breast Cancer Mortality: A Population-based Cohort Study, Epidemiology, vol. 29, pp. 407-413, 2018.
A. M. Mueller, Meier, C. R., Jick, S. S., and Schneider, C., The Potential of Glycemic Control and Body Weight Change as Early Markers for Pancreatic Cancer in Patients With Long-standing Diabetes Mellitus: A Case-Control Study, PancreasPancreasPancreas, vol. 47, pp. 807-815, 2018.
J. W. O'Sullivan, Stevens, S., Oke, J., Hobbs, F. D. R., Salisbury, C., Little, P., Goldacre, B., Bankhead, C., Aronson, J. K., Heneghan, C., and Perera, R., Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16, BMC Med, vol. 16, p. 229, 2018.
[Page last reviewed 13 May 2019]