Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
M. Schmidt, Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sorensen, H. T., Smeeth, L., and Tomlinson, L. A., Adherence to guidelines for creatinine and potassium monitoring and discontinuation following renin-angiotensin system blockade: a UK general practice-based cohort study, BMJ Open, vol. 7, p. e012818, 2017.
B. Numbere, Fleming, K. M., Walker, A., and Card, T. R., Adrenergic blockers and the risk for common solid cancers: a case-control study, Eur J Cancer Prev, vol. 26, pp. 86-93, 2017.
H. Carreira, Williams, R., Muller, M., Harewood, R., and Bhaskaran, K., Adverse mental health outcomes in breast cancer survivors compared to women who did not have cancer: systematic review protocol, Syst Rev, vol. 6, p. 162, 2017.
D. Stewart, Han, L., Doran, T., and McCambridge, J., Alcohol consumption and all-cause mortality: an analysis of general practice database records for patients with long-term conditions, J Epidemiol Community Health, vol. 71, pp. 729-735, 2017.
R. Parisi, Webb, R. T., Carr, M. J., Moriarty, K. J., Kleyn, C. E., Griffiths, C. E. M., and Ashcroft, D. M., Alcohol-Related Mortality in Patients With Psoriasis: A Population-Based Cohort Study, JAMA Dermatol, vol. 153, pp. 1256-1262, 2017.
B. M. Hicks, Klil-Drori, A. J., Yin, H., Campeau, L., and Azoulay, L., Androgen Deprivation Therapy and the Risk of Anemia in Men with Prostate Cancer, Epidemiology, vol. 28, pp. 712-718, 2017.
F. Khosrow-Khavar, Rej, S., Yin, H., Aprikian, A., and Azoulay, L., Androgen Deprivation Therapy and the Risk of Dementia in Patients With Prostate Cancer, J Clin Oncol, vol. 35, pp. 201-207, 2017.
B. M. Hicks, Yin, H., Bladou, F., Ernst, P., and Azoulay, L., Androgen deprivation therapy for prostate cancer and the risk of hospitalisation for community-acquired pneumonia, Thorax, vol. 72, pp. 596-597, 2017.
S. J. Stocks, Kontopantelis, E., Webb, R. T., Avery, A. J., Burns, A., and Ashcroft, D. M., Antipsychotic Prescribing to Patients Diagnosed with Dementia Without a Diagnosis of Psychosis in the Context of National Guidance and Drug Safety Warnings: Longitudinal Study in UK General Practice, Drug Saf, vol. 40, pp. 679-692, 2017.
A. Leite, Andrews, N. J., and Thomas, S. L., Assessing recording delays in general practice records to inform near real-time vaccine safety surveillance using the Clinical Practice Research Datalink (CPRD), Pharmacoepidemiol Drug Saf, vol. 26, pp. 437-445, 2017.
M. Z. Ankarfeldt, Thorsted, B. L., Groenwold, R. H., Adalsteinsson, E., Ali, M. S., and Klungel, O. H., Assessment of channeling bias among initiators of glucose-lowering drugs: A UK cohort study, Clin Epidemiol, vol. 9, pp. 19-30, 2017.
I. Barker, Steventon, A., and Deeny, S. R., Association between continuity of care in general practice and hospital admissions for ambulatory care sensitive conditions: cross sectional study of routinely collected, person level data, Bmj, vol. 356, p. j84, 2017.
R. Baker, Kendrick, D., Tata, L. J., and Orton, E., Association between maternal depression and anxiety episodes and rates of childhood injuries: a cohort study from England, Inj Prev, vol. 23, pp. 396-402, 2017.
S. G. Bruderer, Meier, C. R., Jick, S. S., and Bodmer, M., The association between thyroid disorders and incident gout: population-based case-control study, Clin Epidemiol, vol. 9, pp. 205-215, 2017.
J. Browne, Edwards, D. A., Rhodes, K. M., Brimicombe, D. J., and Payne, R. A., Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study, BMJ Open, vol. 7, p. e012546, 2017.
H. B. Mehta, Mehta, V., and Goodwin, J. S., Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus, J Gerontol A Biol Sci Med Sci, vol. 72, pp. 1110-1116, 2017.
J. M. Gamble, Chibrikov, E., Twells, L. K., Midodzi, W. K., Young, S. W., MacDonald, D., and Majumdar, S. R., Association of insulin dosage with mortality or major adverse cardiovascular events: a retrospective cohort study, Lancet Diabetes Endocrinol, vol. 5, pp. 43-52, 2017.
C. Renoux, Vahey, S., Dell'Aniello, S., and Boivin, J. F., Association of Selective Serotonin Reuptake Inhibitors With the Risk for Spontaneous Intracranial Hemorrhage, JAMA Neurol, vol. 74, pp. 173-180, 2017.
C. Renoux, Dell'Aniello, S., Brenner, B., and Suissa, S., Bias from depletion of susceptibles: the example of hormone replacement therapy and the risk of venous thromboembolism, Pharmacoepidemiol Drug Saf, vol. 26, pp. 554-560, 2017.
S. J. Sinnott, Mansfield, K. E., Schmidt, M., Bhaskaran, K., Smeeth, L., Nitsch, D., and Tomlinson, L. A., Biochemical monitoring after initiation of aldosterone antagonist therapy in users of renin-angiotensin system blockers: a UK primary care cohort study, BMJ Open, vol. 7, p. e018153, 2017.
W. G. Herrington, Smith, M., Bankhead, C., Matsushita, K., Stevens, S., Holt, T., Hobbs, F. D., Coresh, J., and Woodward, M., Body-mass index and risk of advanced chronic kidney disease: Prospective analyses from a primary care cohort of 1.4 million adults in England, PLoS One, vol. 12, p. e0173515, 2017.
V. Navaratnam, Millett, E. R., Hurst, J. R., Thomas, S. L., Smeeth, L., Hubbard, R. B., Brown, J., and Quint, J. K., Bronchiectasis and the risk of cardiovascular disease: a population-based study, Thorax, vol. 72, pp. 161-166, 2017.
S. Langham, Wright, A., Shaw, H., Bryson, S., and O'Leary, S., Budget impact analysis of oral glycopyrronium bromide (Sialanar™) for the symptomatic treatment of severe sialorrhoea (Drooling) in the UK setting, Value in Health, vol. 20, p. A720, 2017.
S. H. Landis, Wurst, K., Le, H. V., Bonar, K., and Punekar, Y. S., Can Assessment of Disease Burden Prior to Changes in Initial COPD Maintenance Treatment Provide Insight into Remaining Unmet Needs? A Retrospective Database Study in UK Primary Care, Copd, vol. 14, pp. 80-85, 2017.
S. F. Weng, Reps, J., Kai, J., Garibaldi, J. M., and Qureshi, N., Can machine-learning improve cardiovascular risk prediction using routine clinical data?, PLoS One, vol. 12, p. e0174944, 2017.
J. A. Kaye, Margulis, A. V., Fortuny, J., McQuay, L. J., Plana, E., Bartsch, J. L., Bui, C. L., Perez-Gutthann, S., and Arana, A., Cancer Incidence after Initiation of Antimuscarinic Medications for Overactive Bladder in the United Kingdom: Evidence for Protopathic Bias, Pharmacotherapy, vol. 37, pp. 673-683, 2017.
A. But, De Bruin, M. L., Bazelier, M. T., Hjellvik, V., Andersen, M., Auvinen, A., Starup-Linde, J., Schmidt, M. K., Furu, K., de Vries, F., Karlstad, O., Ekstrom, N., and Haukka, J., Cancer risk among insulin users: comparing analogues with human insulin in the CARING five-country cohort study, Diabetologia, vol. 60, pp. 1691-1703, 2017.
J. Dollerup, Vestbo, J., Murray-Thomas, T., Kaplan, A., Martin, R. J., Pizzichini, E., Pizzichini, M. M. M., Burden, A., Martin, J., and Price, D. B., Cardiovascular risks in smokers treated with nicotine replacement therapy: a historical cohort study, Clin Epidemiol, vol. 9, pp. 231-243, 2017.
R. Williams, de Vries, F., Kothny, W., Serban, C., Lopez-Leon, S., Chu, C., and Schlienger, R., Cardiovascular safety of vildagliptin in patients with type 2 diabetes: A European multi-database, non-interventional post-authorization safety study, Diabetes Obes Metab, vol. 19, pp. 1473-1478, 2017.
J. P. H. Wilding, Godec, T., Khunti, K., Pocock, S., Fox, R., Smeeth, L., Clauson, P., Fenici, P., Hammar, N., and Medina, J., Changes in HbA1c and weight after initiation of second-line therapy in patients with type 2 diabetes in clinical practice., Diabetologia., vol. 60, p. S301, 2017.
R. B. Weinstein, Ryan, P., Berlin, J. A., Matcho, A., Schuemie, M., Swerdel, J., Patel, K., and Fife, D., Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications, Drug Saf, vol. 40, pp. 1279-1292, 2017.
S. Ramtoola, Ploug, U. J., Kragh, N., and Nyeland, M. E., Characteristics of newly diagnosed adults with Type 1 diabetes in the UK and their evolution over the first 5 years, Diabetic Medicine, vol. 34, p. 146, 2017.
C. Miani, Martin, A., Exley, J., Doble, B., Wilson, E., Payne, R., Avery, A., Meads, C., Kirtley, A., Jones, M. M., and King, S., Clinical effectiveness and cost-effectiveness of issuing longer versus shorter duration (3-month vs. 28-day) prescriptions in patients with chronic conditions: systematic review and economic modelling, Health Technol Assess, vol. 21, pp. 1-128, 2017.
S. A. Stapley, Rubin, G. P., Alsina, D., Shephard, E. A., Rutter, M. D., and Hamilton, W. T., Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study, Br J Gen Pract, vol. 67, pp. e336-e344, 2017.
S. E. Bailey, Ukoumunne, O. C., Shephard, E. A., and Hamilton, W., Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data, Br J Gen Pract, vol. 67, pp. e405-e413, 2017.
L. R. Rodgers, Weedon, M. N., Henley, W. E., Hattersley, A. T., and Shields, B. M., Cohort profile for the MASTERMIND study: using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with type 2 diabetes, BMJ Open, vol. 7, p. e017989, 2017.
S. Venkatesan, Myles, P. R., Manning, H. J., Mozid, A. M., Andersson, C., Jorgensen, M. E., Hardman, J. G., Moonesinghe, S. R., Foex, P., Mythen, M., Grocott, M. P. W., and Sanders, R. D., Cohort study of preoperative blood pressure and risk of 30-day mortality after elective non-cardiac surgery, Br J Anaesth, vol. 119, pp. 65-77, 2017.
O. B. Sanni, Menamin, U. C. Mc, Cardwell, C. R., Sharp, L., Murray, L. J., and Coleman, H. G., Commonly used medications and endometrial cancer survival: a population-based cohort study, Br J Cancer, vol. 117, pp. 432-438, 2017.
L. T. A. Mounce, Price, S., Valderas, J. M., and Hamilton, W., Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records, Br J Cancer, vol. 116, pp. 1536-1543, 2017.
C. S. Murray, Thomas, M., Richardson, K., Price, D. B., and Turner, S. W., Comparative Effectiveness of Step-up Therapies in Children with Asthma Prescribed Inhaled Corticosteroids: A Historical Cohort Study, J Allergy Clin Immunol Pract, vol. 5, pp. 1082-1090.e7, 2017.
T. Sheppard, Tamblyn, R., Abrahamowicz, M., Lunt, M., Sperrin, M., and Dixon, W. G., A comparison of methods for estimating the temporal change in a continuous variable: Example of HbA1c in patients with diabetes, Pharmacoepidemiol Drug Saf, vol. 26, pp. 1474-1482, 2017.
S. Suissa, Dell'Aniello, S., and Ernst, P., Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events, Eur Respir J, vol. 49, 2017.
S. Skrtic, Cabrera, C., Olsson, M., Schnecke, V., and Lind, M., Contemporary risk estimates of three HbA1c variables in relation to heart failure following diagnosis of type 2 diabetes, Heart, vol. 103, pp. 353-358, 2017.
P. Tammes, Purdy, S., Salisbury, C., MacKichan, F., Lasserson, D., and Morris, R. W., Continuity of Primary Care and Emergency Hospital Admissions Among Older Patients in England, Ann Fam Med, vol. 15, pp. 515-522, 2017.
S. J. Ronaldson, Raghunath, A., Torgerson, D. J., and Van Staa, T., Cost-effectiveness of antibiotics for COPD management: observational analysis using CPRD data, ERJ Open Res, vol. 3, 2017.
J. Leal, Gray, A. M., Hawley, S., Prieto-Alhambra, D., Delmestri, A., Arden, N. K., Cooper, C., Javaid, M. K., and Judge, A., Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study, J Bone Miner Res, vol. 32, pp. 203-211, 2017.
M. C. Gulliford, Charlton, J., Prevost, T., Booth, H., Fildes, A., Ashworth, M., Littlejohns, P., Reddy, M., Khan, O., and Rudisill, C., Costs and Outcomes of Increasing Access to Bariatric Surgery: Cohort Study and Cost-Effectiveness Analysis Using Electronic Health Records, Value Health, vol. 20, pp. 85-92, 2017.
C. Francois, Tanasescu, A., Lamy, F. X., Despiegel, N., Falissard, B., Chalem, Y., Lancon, C., Llorca, P. M., Saragoussi, D., Verpillat, P., Wade, A. G., and Zighed, D. A., Creating an index to measure health state of depressed patients in automated healthcare databases: the methodology, J Mark Access Health Policy, vol. 5, p. 1372025, 2017.
J. Wilding, Bailey, C., Rigney, U., Blak, B., Kok, M., and Emmas, C., Dapagliflozin therapy for type 2 diabetes in primary care: Changes in HbA1c, weight and blood pressure over 2 years follow-up, Prim Care Diabetes, vol. 11, pp. 437-444, 2017.
[Page last reviewed 13 May 2019]