Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
J. M. Dennis, Shields, B. M., Hill, A. V., Knight, B. A., McDonald, T. J., Rodgers, L. R., Weedon, M. N., Henley, W. E., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., and Jones, A. G., Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy, Diabetes Care, vol. 41, pp. 705-712, 2018.
S. W. D. Merriel, May, M. T., and Martin, R. M., Predicting prostate cancer progression: protocol for a retrospective cohort study to identify prognostic factors for prostate cancer outcomes using routine primary care data, BMJ Open, vol. 8, p. e019409, 2018.
C. L. Burton, Chesterton, L. S., Chen, Y., and van der Windt, D. A., Predicting surgical intervention in patients presenting with carpal tunnel syndrome in primary care, Clin Epidemiol, vol. 10, pp. 739-748, 2018.
F. Rahimian, Salimi-Khorshidi, G., Payberah, A. H., Tran, J., R. Solares, A., Raimondi, F., Nazarzadeh, M., Canoy, D., and Rahimi, K., Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records, PLoS Med, vol. 15, p. e1002695, 2018.
G. Nakafero, Grainge, M. J., Myles, P. R., Mallen, C. D., Zhang, W., Doherty, M., Nguyen-Van-Tam, J. S., and Abhishek, A., Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study, Rheumatology (Oxford), vol. 57, pp. 1726-1734, 2018.
T. Newlove-Delgado, Ford, T. J., Hamilton, W., Stein, K., and Ukoumunne, O. C., Prescribing of medication for attention deficit hyperactivity disorder among young people in the Clinical Practice Research Datalink 2005-2013: analysis of time to cessation, Eur Child Adolesc Psychiatry, vol. 27, pp. 29-35, 2018.
D. Spanopoulos, Barrett, B., Busse, M., Roman, T., and Poole, C., Prescription of DPP-4 Inhibitors to Patients With Adult Type 2 Diabetes Mellitus and Creatinine Clearance>50 mL/min: The UK Primary Care Experience, Clin Ther, vol. 40, pp. 1424-1428.e4, 2018.
D. Spanopoulos, Barrett, B., Busse, M., Roman, T., and Poole, C., Prescription of DPP-4 Inhibitors to Type 2 Diabetes Mellitus Patients With Renal Impairment: A UK Primary Care Experience, Clin Ther, vol. 40, pp. 152-154, 2018.
S. H. Mahmoudpour, Asselbergs, F. W., Souverein, P. C., de Boer, A., and van der Zee, A. H. Maitlan, Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study, Br J Clin Pharmacol, vol. 84, pp. 2365-2372, 2018.
M. D. Danese, Sidelnikov, E., and Kutikova, L., The prevalence, low-density lipoprotein cholesterol levels, and treatment of patients at very high risk of cardiovascular events in the United Kingdom: a cross-sectional study, Curr Med Res Opin, vol. 34, pp. 1441-1447, 2018.
G. Disanto, Zecca, C., MacLachlan, S., Sacco, R., Handunnetthi, L., Meier, U. C., Simpson, A., McDonald, L., Rossi, A., Benkert, P., Kuhle, J., Ramagopalan, S. V., and Gobbi, C., Prodromal symptoms of multiple sclerosis in primary care, Ann Neurol, vol. 83, pp. 1162-1173, 2018.
P. Imfeld, Bodmer, M., Jick, S. S., and Meier, C. R., Proton Pump Inhibitor Use and Risk of Developing Alzheimer's Disease or Vascular Dementia: A Case-Control Analysis, Drug Saf, vol. 41, pp. 1387-1396, 2018.
V. S. Hegade, Mells, G. F., Fisher, H., Kendrick, S., DiBello, J., Gilchrist, K., Alexander, G. J., Hirschfield, G. M., Sandford, R. N., and Jones, D. E. J., Pruritus is Common and Under-treated in Patients with Primary Biliary Cholangitis in the United Kingdom, Clin Gastroenterol Hepatol, 2018.
R. Houghton, Liu, C., and Bolognani, F., Psychiatric Comorbidities and Psychotropic Medication Use in Autism: A Matched Cohort Study with ADHD and General Population Comparator Groups in the United Kingdom, Autism Res, 2018.
R. Parisi, Webb, R. T., Kleyn, C. E., Carr, M. J., Kapur, N., Griffiths, C. E. M., and Ashcroft, D. M., Psychiatric morbidity and suicidal behaviour in psoriasis: a primary care cohort study, Br J Dermatol, 2018.
R. I. Griffiths, McFadden, E. C., Stevens, R. J., Valderas, J. M., Lavery, B. A., Khan, N. F., Keating, N. L., and Bankhead, C. R., Quality of diabetes care in breast, colorectal, and prostate cancer, J Cancer Surviv, vol. 12, pp. 803-812, 2018.
J. Voorham, Roche, N., Benhaddi, H., van der Tol, M., Carter, V., van Boven, J. F. M., Bjermer, L., Miravitlles, M., and Price, D. B., Real-world effectiveness evaluation of budesonide/formoterol Spiromax for the management of asthma and chronic obstructive pulmonary disease in the UK, BMJ Open, vol. 8, p. e022051, 2018.
K. Wing, Williamson, E., Carpenter, J. R., Wise, L., Schneeweiss, S., Smeeth, L., Quint, J. K., and Douglas, I., Real-world effects of medications for chronic obstructive pulmonary disease: protocol for a UK population-based non-interventional cohort study with validation against randomised trial results, BMJ Open, vol. 8, p. e019475, 2018.
A. Bottle, Kim, D., Aylin, P. P., Majeed, F. A., Cowie, M. R., and Hayhoe, B., Real-world presentation with heart failure in primary care: do patients selected to follow diagnostic and management guidelines have better outcomes?, Open Heart, vol. 5, p. e000935, 2018.
J. K. Quint, Moore, E., Lewis, A., Hashmi, M., Sultana, K., Wright, M., Smeeth, L., Chatzidiakou, L., Jones, R., Beevers, S., Kolozali, S., Kelly, F., and Barratt, B., Recruitment of patients with Chronic Obstructive Pulmonary Disease (COPD) from the Clinical Practice Research Datalink (CPRD) for research, NPJ Prim Care Respir Med, vol. 28, p. 21, 2018.
S. R. Markar, Arhi, C., Wiggins, T., Vidal-Diez, A., Karthikesalingam, A., Darzi, A., Lagergren, J., and Hanna, G. B., Reintervention After Antireflux Surgery for Gastroesophageal Reflux Disease in England, Ann Surg, 2018.
G. Geulayov, Ferrey, A., Casey, D., Wells, C., Fuller, A., Bankhead, C., Gunnell, D., Clements, C., Kapur, N., Ness, J., Waters, K., and Hawton, K., Relative toxicity of benzodiazepines and hypnotics commonly used for self-poisoning: An epidemiological study of fatal toxicity and case fatality, J Psychopharmacol, vol. 32, pp. 654-662, 2018.
A. E. Ferrey, Geulayov, G., Casey, D., Wells, C., Fuller, A., Bankhead, C., Ness, J., Clements, C., Gunnell, D., Kapur, N., and Hawton, K., Relative toxicity of mood stabilisers and antipsychotics: case fatality and fatal toxicity associated with self-poisoning, BMC Psychiatry, vol. 18, p. 399, 2018.
G. Dell'Agnello, Desai, U., Kirson, N. Y., Wen, J., Meiselbach, M. K., Reed, C. C., Belger, M., Lenox-Smith, A., Martinez, C., and Rasmussen, J., Reliability of coded data to identify earliest indications of cognitive decline, cognitive evaluation and Alzheimer's disease diagnosis: a pilot study in England, BMJ Open, vol. 8, p. e019684, 2018.
R. Costello, Jacklin, C., M. Evans, J., McBeth, J., and Dixon, W. G., Representativeness of a digitally engaged population and a patient organisation population with rheumatoid arthritis and their willingness to participate in research: a cross-sectional study, RMD Open, vol. 4, p. e000664, 2018.
S. Rajaram, Wiecek, W., Lawson, R., Blak, B., Zhao, Y., Hackett, J., Brody, R., Salimi, T., Amzal, B., and Patel, V., A retrospective observational analysis of post-pandemic influenza-related outcomes in the United Kingdom, 2010-2014, Hum Vaccin Immunother, vol. 14, pp. 368-377, 2018.
A. Abhishek, Nakafero, G., Kuo, C. F., Mallen, C., Zhang, W., Grainge, M. J., and Doherty, M., Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink, Rheumatology (Oxford), vol. 57, pp. 977-981, 2018.
S. Gale, Wilson, J. C., Chia, J., Trinh, H., Tuckwell, K., Collinson, N., Dimonaco, S., Jick, S., Meier, C., Mohan, S. V., and Sarsour, K., Risk Associated with Cumulative Oral Glucocorticoid Use in Patients with Giant Cell Arteritis in Real-World Databases from the USA and UK, Rheumatol Ther, 2018.
E. L. Axson, Bual, N., Bloom, C. I., and Quint, J. K., Risk factors and secondary care utilisation in a primary care population with non-tuberculous mycobacterial disease in the UK, Eur J Clin Microbiol Infect Dis, 2018.
P. Karimi, Birmann, B. M., Anderson, L. A., McShane, C. M., Gadalla, S. M., Sampson, J. N., and Mbulaiteye, S. M., Risk factors for Burkitt lymphoma: a nested case-control study in the UK Clinical Practice Research Datalink, Br J Haematol, vol. 181, pp. 505-514, 2018.
J. J. Lee, Bankhead, C., Smith, M., Kousoulis, A. A., Butler, C. C., and Wang, K., Risk factors for influenza-related complications in children during the 2009/10 pandemic: a UK primary care cohort study using linked routinely collected data, Epidemiol Infect, vol. 146, pp. 817-823, 2018.
H. C. Gorton, Webb, R. T., Pickrell, W. O., Carr, M. J., and Ashcroft, D. M., Risk factors for self-harm in people with epilepsy, J Neurol, vol. 265, pp. 3009-3016, 2018.
J. van Dalem, Brouwers, M., Stehouwer, C. D. A., Krings, A., Klungel, O. H., Driessen, J. H. M., de Vries, F., and Burden, A. M., Risk of a first-ever acute myocardial infarction and all-cause mortality with sulphonylurea treatment: A population-based cohort study, Diabetes Obes Metab, vol. 20, pp. 1056-1060, 2018.
H. Ahmed, Farewell, D., Francis, N. A., Paranjothy, S., and Butler, C. C., Risk of adverse outcomes following urinary tract infection in older people with renal impairment: Retrospective cohort study using linked health record data, PLoS Med, vol. 15, p. e1002652, 2018.
M. Roughley, Sultan, A. A., Clarson, L., Muller, S., Whittle, R., Belcher, J., Mallen, C. D., and Roddy, E., Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study, Arthritis Res Ther, vol. 20, p. 243, 2018.
Z. Paskins, Whittle, R., Sultan, A. A., Muller, S., Blagojevic-Bucknall, M., Helliwell, T., Hider, S., Roddy, E., and Mallen, C., Risk of fracture among patients with polymyalgia rheumatica and giant cell arteritis: a population-based study, BMC Med, vol. 16, p. 4, 2018.
A. A. Sultan, Whittle, R., Muller, S., Roddy, E., Mallen, C. D., Bucknall, M., Helliwell, T., Hider, S., and Paskins, Z., Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy, Cmaj, vol. 190, pp. E581-e587, 2018.
Z. Paskins, Whittle, R., A. Sultan, A., Muller, S., Blagojevic-Bucknall, M., Helliwell, T., Packham, J., Hider, S., Roddy, E., and Mallen, C., Risk of fragility fracture among patients with late-onset psoriasis: a UK population-based study, Osteoporos Int, vol. 29, pp. 1659-1664, 2018.
J. M. Gamble, Donnan, J. R., Chibrikov, E., Twells, L. K., Midodzi, W. K., and Majumdar, S. R., The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study, Diabetes Res Clin Pract, vol. 136, pp. 159-167, 2018.
S. Erridge, Moussa, O. M., Ziprin, P., Darzi, A., and Purkayastha, S., Risk of GERD-Related Disorders in Obese Patients on PPI Therapy: a Population Analysis, Obes Surg, vol. 28, pp. 2796-2803, 2018.
M. Blagojevic-Bucknall, Mallen, C., Muller, S., Hayward, R., West, S., Choi, H., and Roddy, E., The risk of gout among patients with sleep apnea: a matched cohort study, Arthritis Rheumatol, 2018.
T. Burkard, Hugle, T., Layton, J. B., Glynn, R. J., Bloechliger, M., Frey, N., Jick, S. S., Meier, C. R., and Spoendlin, J., Risk of Incident Osteoarthritis of the Hand in Statin Initiators: A Sequential Cohort Study, Arthritis Care Res (Hoboken), vol. 70, pp. 1795-1805, 2018.
Y. Wang, Pfeiffer, R. M., Alsaggaf, R., Meeraus, W., Gage, J. C., Anderson, L. A., Bremer, R. C., Nikolenko, N., Lochmuller, H., Greene, M. H., and Gadalla, S. M., Risk of skin cancer among patients with myotonic dystrophy type 1 based on primary care physician data from the U.K. Clinical Practice Research Datalink, Int J Cancer, vol. 142, pp. 1174-1181, 2018.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C., and McHugh, N., Risk of type 2 diabetes and cardiovascular disease in an incident cohort of people with psoriatic arthritis: a population-based cohort study, Rheumatology (Oxford), 2018.
H. C. Gorton, Webb, R. T., Carr, M. J., DelPozo-Banos, M., John, A., and Ashcroft, D. M., Risk of Unnatural Mortality in People With Epilepsy, JAMA Neurol, vol. 75, pp. 929-938, 2018.
R. Charlton, Green, A., Shaddick, G., Snowball, J., Nightingale, A., Tillett, W., Smith, C. H., and McHugh, N., Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study, Ann Rheum Dis, vol. 77, pp. 277-280, 2018.
E. Martin-Merino, Petersen, I., Hawley, S., Alvarez-Gutierrez, A., Khalid, S., Llorente-Garcia, A., Delmestri, A., Javaid, M. K., van Staa, T. P., Judge, A., Cooper, C., and Prieto-Alhambra, D., Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK, Osteoporos Int, vol. 29, pp. 467-478, 2018.
T. P. C. Chu, Grainge, M. J., and Card, T. R., The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity, Aliment Pharmacol Ther, vol. 48, pp. 1099-1108, 2018.
Y. Vinogradova, Coupland, C., Hill, T., and Hippisley-Cox, J., Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care, Bmj, vol. 362, p. k2505, 2018.
A. Bottle, Kim, D., Aylin, P., Cowie, M. R., Majeed, A., and Hayhoe, B., Routes to diagnosis of heart failure: observational study using linked data in England, Heart, vol. 104, pp. 600-605, 2018.
[Page last reviewed 13 May 2019]