Research using CPRD data has informed drug safety guidance and clinical practice and resulted in over 2,200 peer-reviewed publications.

The CPRD bibliography is updated on a monthly basis (last updated 3 May 2019) and papers are listed below.

If you have published papers using CPRD data which are not included in this list, please contact us at so that we can update the bibliography.


Export 2237 results:
Author Title Type [ Year(Asc)]
P. Bryan, Seabroke, S., Wong, J., Donegan, K., Webb, E., Goldsmith, C., Vipond, C., and Feavers, I., Safety of multicomponent meningococcal group B vaccine (4CMenB) in routine infant immunisation in the UK: a prospective surveillance study, Lancet Child Adolesc Health, vol. 2, pp. 395-403, 2018.
S. Muller, Hider, S., Machin, A., Stack, R., Hayward, R. A., Raza, K., and Mallen, C., Searching for a prodrome for rheumatoid arthritis in the primary care record: A case-control study in the clinical practice research datalink, Semin Arthritis Rheum, 2018.
E. A. Shephard and Hamilton, W. T., Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records, Br J Gen Pract, vol. 68, pp. e559-e565, 2018.
J. Busby, Mills, K., Zhang, S. D., Liberante, F. G., and Cardwell, C. R., Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study, Breast Cancer Res, vol. 20, p. 4, 2018.
C. Morgan, Webb, R. T., Carr, M. J., Kontopantelis, E., Chew-Graham, C. A., Kapur, N., and Ashcroft, D. M., Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death, Lancet Psychiatry, vol. 5, pp. 905-912, 2018.
H. Furuland, McEwan, P., Evans, M., Linde, C., Ayoubkhani, D., Bakhai, A., Palaka, E., Bennett, H., and Qin, L., Serum potassium as a predictor of adverse clinical outcomes in patients with chronic kidney disease: new risk equations using the UK clinical practice research datalink, BMC Nephrol, vol. 19, p. 211, 2018.
R. J. Silverwood, Forbes, H. J., Abuabara, K., Ascott, A., Schmidt, M., Schmidt, S. A. J., Smeeth, L., and Langan, S. M., Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study, Bmj, vol. 361, p. k1786, 2018.
M. Iwagami, Mansfield, K. E., Hayes, J. F., Walters, K., Osborn, D. P., Smeeth, L., Nitsch, D., and Tomlinson, L. A., Severe mental illness and chronic kidney disease: a cross-sectional study in the United Kingdom, Clin Epidemiol, vol. 10, pp. 421-429, 2018.
J. M. Dennis, Henley, W. E., Weedon, M. N., Lonergan, M., Rodgers, L. R., Jones, A. G., Hamilton, W. T., Sattar, N., Janmohamed, S., Holman, R. R., Pearson, E. R., Shields, B. M., and Hattersley, A. T., Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data, Diabetes Care, vol. 41, pp. 1844-1853, 2018.
S. Weir, Samnaliev, M., Kuo, T. C., Tierney, T. S., S. Autiero, W., Taylor, R. S., and Schrag, A., Short- and long-term cost and utilization of health care resources in Parkinson's disease in the UK, Mov Disord, vol. 33, pp. 974-981, 2018.
E. Kontopantelis, Stevens, R. J., Helms, P. J., Edwards, D., Doran, T., and Ashcroft, D. M., Spatial distribution of clinical computer systems in primary care in England in 2016 and implications for primary care electronic medical record databases: a cross-sectional population study, BMJ Open, vol. 8, p. e020738, 2018.
Z. Liu, Alsaggaf, R., McGlynn, K. A., Anderson, L. A., Tsai, H. T., Zhu, B., Zhu, Y., Mbulaiteye, S. M., Gadalla, S. M., and Koshiol, J., Statin use and reduced risk of biliary tract cancers in the UK Clinical Practice Research Datalink, Gut, 2018.
A. D. Spence, Busby, J., Hughes, C. M., Johnston, B. T., Coleman, H. G., and Cardwell, C. R., Statin use and survival in patients with gastric cancer in two independent population-based cohorts, Pharmacoepidemiol Drug Saf, 2018.
K. Chidwick, Strongman, H., Matthews, A., Stanway, S., Lyon, A. R., Smeeth, L., and Bhaskaran, K., Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink, BMC Cancer, vol. 18, p. 1018, 2018.
A. Pate, Barrowman, M., Webb, D., Pimenta, J. M., Davis, K. J., Williams, R., Van Staa, T., and Sperrin, M., Study investigating the generalisability of a COPD trial based in primary care (Salford Lung Study) and the presence of a Hawthorne effect, BMJ Open Respir Res, vol. 5, p. e000339, 2018.
O. Yu, Azoulay, L., Yin, H., Filion, K. B., and Suissa, S., Sulfonylureas as Initial Treatment for Type 2 Diabetes and the Risk of Severe Hypoglycemia, Am J Med, vol. 131, pp. 317.e11-317.e22, 2018.
A. Douros, Dell'Aniello, S., Yu, O. H. Y., Filion, K. B., Azoulay, L., and Suissa, S., Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study, Bmj, vol. 362, p. k2693, 2018.
R. M. Joseph, Soames, J., Wright, M., Sultana, K., van Staa, T. P., and Dixon, W. G., Supplementing electronic health records through sample collection and patient diaries: A study set within a primary care research database, Pharmacoepidemiol Drug Saf, vol. 27, pp. 239-242, 2018.
N. Conrad, Judge, A., Tran, J., Mohseni, H., Hedgecott, D., Crespillo, A. P., Allison, M., Hemingway, H., Cleland, J. G., McMurray, J. J. V., and Rahimi, K., Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals, Lancet, vol. 391, pp. 572-580, 2018.
J. W. O'Sullivan, Stevens, S., Hobbs, F. D. R., Salisbury, C., Little, P., Goldacre, B., Bankhead, C., Aronson, J. K., Perera, R., and Heneghan, C., Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests, Bmj, vol. 363, p. k4666, 2018.
C. Martinez, Katholing, A., Folkerts, K., and Rietbrock, S., Thirteen-year trend in the persistence with vitamin K antagonists for venous thromboembolism in the UK: a cohort study, Curr Med Res Opin, vol. 34, pp. 1985-1990, 2018.
U. Desai, Kirson, N. Y., Kim, J., Khunti, K., King, S., Trieschman, E., Hellstern, M., Hunt, P. R., and Mukherjee, J., Time to Treatment Intensification After Monotherapy Failure and Its Association With Subsequent Glycemic Control Among 93,515 Patients With Type 2 Diabetes, Diabetes Care, vol. 41, pp. 2096-2104, 2018.
H. J. Curtis, Dennis, J. M., Shields, B. M., Walker, A. J., Bacon, S., Hattersley, A. T., Jones, A. G., and Goldacre, B., Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017, Diabetes Obes Metab, vol. 20, pp. 2159-2168, 2018.
S. M. Grandi, Reynier, P., Platt, R. W., Basso, O., and Filion, K. B., The timing of onset of hypertensive disorders in pregnancy and the risk of incident hypertension and cardiovascular disease, Int J Cardiol, vol. 270, pp. 273-275, 2018.
J. A. Hirst, Farmer, A. J., Smith, M. C., and Stevens, R. J., Timings for HbA1c testing in people with diabetes are associated with incentive payments: an analysis of UK primary care data, Diabet Med, 2018.
J. Charlton, Ravindrarajah, R., Hamada, S., Jackson, S. H., and Gulliford, M. C., Trajectory of Total Cholesterol in the Last Years of Life Over Age 80 Years: Cohort Study of 99,758 Participants, J Gerontol A Biol Sci Med Sci, vol. 73, pp. 1083-1089, 2018.
J. Gordon, McEwan, P., Idris, I., Evans, M., and Puelles, J., Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study, BMJ Open Diabetes Res Care, vol. 6, p. e000512, 2018.
I. Idris, Peng, X., He, X., Liu, D., Balogh, E., Kaushik, P., and van Brunt, K., The Trend of High-Dose Insulin Usage Among Patients with Diabetes in the UK: A Retrospective Study, Diabetes Ther, vol. 9, pp. 2245-2257, 2018.
E. Burn, Edwards, C. J., Murray, D. W., Silman, A., Cooper, C., Arden, N. K., Pinedo-Villanueva, R., and Prieto-Alhambra, D., Trends and determinants of length of stay and hospital reimbursement following knee and hip replacement: evidence from linked primary care and NHS hospital records from 1997 to 2014, BMJ Open, vol. 8, p. e019146, 2018.
V. W. Zhong, Juhaeri, J., and Mayer-Davis, E. J., Trends in Hospital Admission for Diabetic Ketoacidosis in Adults With Type 1 and Type 2 Diabetes in England, 1998-2013: A Retrospective Cohort Study, Diabetes Care, vol. 41, pp. 1870-1877, 2018.
O. A. Oshagbemi, Keene, S. J., Driessen, J. H. M., Jordan, R., Wouters, E. F. M., de Boer, A., de Vries, F., and Franssen, F. M. E., Trends in moderate and severe exacerbations among COPD patients in the UK from 2005 to 2013, Respir Med, vol. 144, pp. 1-6, 2018.
C. L. Burton, Chen, Y., Chesterton, L. S., and van der Windt, D. A., Trends in the prevalence, incidence and surgical management of carpal tunnel syndrome between 1993 and 2013: an observational analysis of UK primary care records, BMJ Open, vol. 8, p. e020166, 2018.
E. Crellin, Mansfield, K. E., Leyrat, C., Nitsch, D., Douglas, I. J., Root, A., Williamson, E., Smeeth, L., and Tomlinson, L. A., Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study, Bmj, vol. 360, p. k341, 2018.
L. McDonald, Sammon, C. J., Samnaliev, M., and Ramagopalan, S., Under-recording of hospital bleeding events in UK primary care: a linked Clinical Practice Research Datalink and Hospital Episode Statistics study, Clin Epidemiol, vol. 10, pp. 1155-1168, 2018.
D. Yu, Jordan, K. P., and Peat, G., Underrecording of osteoarthritis in United Kingdom primary care electronic health record data, Clin Epidemiol, vol. 10, pp. 1195-1201, 2018.
F. Ahmadizar, Souverein, P., de Boer, A., and van der Zee, A. H. Maitlan, Undertreatment of hypertension and hypercholesterolaemia in children and adolescents with type 1 diabetes: long-term follow-up on time trends in the occurrence of cardiovascular disease, risk factors and medications use, Br J Clin Pharmacol, vol. 84, pp. 776-785, 2018.
C. F. Kuo, Chou, I. J., See, L. C., Chen, J. S., Yu, K. H., Luo, S. F., Hsieh, A. H., Zhang, W., and Doherty, M., Urate-lowering treatment and risk of total joint replacement in patients with gout, Rheumatology (Oxford), vol. 57, pp. 2129-2139, 2018.
A. Douros, Abrahami, D., Yin, H., Yu, O. H. Y., Renoux, C., Hudson, M., and Azoulay, L., Use of Dipeptidyl Peptidase-4 Inhibitors and New-onset Rheumatoid Arthritis in Patients with Type 2 Diabetes, Epidemiology, vol. 29, pp. 904-912, 2018.
A. Keyany, Nielen, J. T. H., Souverein, P. C., de Vries, F., and van den Bemt, B., Use of parenteral glucocorticoids and the risk of new onset type 2 diabetes mellitus: A case-control study, Diabetes Res Clin Pract, vol. 139, pp. 100-106, 2018.
P. Tammes, Sartini, C., Preston, I., Hay, A. D., Lasserson, D., and Morris, R. W., Use of primary care data to predict those most vulnerable to cold weather: a case-crossover analysis, Br J Gen Pract, vol. 68, pp. e146-e156, 2018.
A. Tran-Duy, Connell, N. J., Vanmolkot, F. H., Souverein, P. C., de Wit, N. J., Stehouwer, C. D. A., Hoes, A. W., de Vries, F., and de Boer, A., Use of proton pump inhibitors and risk of iron deficiency: a population-based case-control study, J Intern Med, 2018.
J. G. Kuiper, van Herk-Sukel, M. P. P., Castellsague, J., Pottegard, A., Berglind, I. A., Dedman, D., Gutierrez, L., Calingaert, B., Hallas, J., Sundstrom, A., Gallagher, A. M., Kaye, J. A., Pardo, C., Rothman, K. J., and Perez-Gutthann, S., Use of Topical Tacrolimus and Topical Pimecrolimus in Four European Countries: A Multicentre Database Cohort Study, Drugs Real World Outcomes, 2018.
S. S. Zghebi, Rutter, M. K., Ashcroft, D. M., Salisbury, C., Mallen, C., Chew-Graham, C. A., Reeves, D., van Marwijk, H., Qureshi, N., Weng, S., Peek, N., Planner, C., Nowakowska, M., Mamas, M., and Kontopantelis, E., Using electronic health records to quantify and stratify the severity of type 2 diabetes in primary care in England: rationale and cohort study design, BMJ Open, vol. 8, p. e020926, 2018.
S. L. Stevens, McManus, R. J., and Stevens, R. J., The utility of long-term blood pressure variability for cardiovascular risk prediction in primary care, J Hypertens, 2018.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Validation of Cancer Cases Using Primary Care, Cancer Registry, and Hospitalization Data in the United Kingdom, Epidemiology, vol. 29, pp. 308-313, 2018.
R. J. Ferguson, Prieto-Alhambra, D., Walker, C., Yu, D., Valderas, J. M., Judge, A., Griffiths, J., Jordan, K. P., Peat, G., Glyn-Jones, S., and Silman, A. J., Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink, Pharmacoepidemiol Drug Saf, 2018.
C. J. Crooks, West, J., and Jepsen, P., A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink, Clin Epidemiol, vol. 10, pp. 107-120, 2018.
A. V. Margulis, Fortuny, J., Kaye, J. A., Calingaert, B., Reynolds, M., Plana, E., McQuay, L. J., Atsma, W. J., Franks, B., de Vogel, S., Perez-Gutthann, S., and Arana, A., Value of Free-text Comments for Validating Cancer Cases Using Primary-care Data in the United Kingdom, Epidemiology, vol. 29, pp. e41-e42, 2018.
A. Arana, Margulis, A. V., McQuay, L. J., Ziemiecki, R., Bartsch, J. L., Rothman, K. J., Franks, B., D'Silva, M., Appenteng, K., Varas-Lorenzo, C., and Perez-Gutthann, S., Variation in Cardiovascular Risk Related to Individual Antimuscarinic Drugs Used to Treat Overactive Bladder: A UK Cohort Study, Pharmacotherapy, vol. 38, pp. 628-637, 2018.
V. M. Walker, Davies, N. M., Kehoe, P. G., and Martin, R. M., What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink, Alzheimers Res Ther, vol. 10, p. 51, 2018.
[Page last reviewed 13 May 2019]